VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

PRUDENTIAL PLC's Holding History (CIK: 0000898419)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,771 Value ($000) $7,150 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 16,568 Value ($000) $6,489 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 19,525 Value ($000) $8,693 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 20,067 Value ($000) $9,729 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 25,518 Value ($000) $10,276 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 29,287 Value ($000) $13,621 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 35,513 Value ($000) $16,646 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 36,047 Value ($000) $15,068 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 37,596 Value ($000) $15,297 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 43,594 Value ($000) $15,159 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 49,649 Value ($000) $17,472 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 59,757 Value ($000) $18,828 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 62,151 Value ($000) $17,948 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 58,272 Value ($000) $16,872 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 41,099 Value ($000) $11,581 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 39,288 Value ($000) $10,253 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 36,041 Value ($000) $7,915 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 37,167 Value ($000) $6,742 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 39,781 Value ($000) $8,021 Avg Close $209.17 Range $185.33 - $222.78

Q2 2019

Shares 1,249 Value ($000) $229 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,249 Value ($000) $230 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,249 Value ($000) $207 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,449 Value ($000) $279 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 2,749 Value ($000) $467 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 2,749 Value ($000) $448 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 1,813 Value ($000) $272 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 1,813 Value ($000) $276 Avg Close $150.51 Range $125.50 - $167.86

Q4 2015

Shares 1,664 Value ($000) $209 Avg Close $120.72 Range $101.49 - $134.71

Q2 2015

Shares 1,664 Value ($000) $205 Avg Close $125.98 Range $113.68 - $137.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,771	$7,150	$431.03	$392.50 - $464.44
Q3 2025	16,568	$6,489	$417.92	$362.50 - $484.56
Q2 2025	19,525	$8,693	$460.83	$416.60 - $510.77
Q1 2025	20,067	$9,729	$466.00	$397.25 - $519.68
Q4 2024	25,518	$10,276	$463.53	$377.85 - $519.88
Q3 2024	29,287	$13,621	$480.37	$456.07 - $510.64
Q2 2024	35,513	$16,646	$434.05	$391.01 - $486.43
Q1 2024	36,047	$15,068	$422.74	$403.43 - $448.40
Q4 2023	37,596	$15,297	$369.42	$341.85 - $413.00
Q3 2023	43,594	$15,159	$349.73	$335.82 - $367.00
Q2 2023	49,649	$17,472	$336.94	$313.47 - $354.94
Q1 2023	59,757	$18,828	$299.93	$282.21 - $325.19
Q4 2022	62,151	$17,948	$304.77	$283.58 - $324.75
Q3 2022	58,272	$16,872	$287.72	$271.61 - $305.95
Q2 2022	41,099	$11,581	$267.66	$233.01 - $293.17
Q1 2022	39,288	$10,253	$237.33	$214.66 - $263.58
Q4 2021	36,041	$7,915	$194.45	$176.36 - $224.49
Q3 2021	37,167	$6,742	$195.24	$180.02 - $204.88
Q2 2021	39,781	$8,021	$209.17	$185.33 - $222.78
Q2 2019	1,249	$229	$174.82	$163.68 - $191.71
Q1 2019	1,249	$230	$184.70	$160.95 - $195.81
Q4 2018	1,249	$207	$173.27	$151.80 - $194.92
Q3 2018	1,449	$279	$178.07	$164.70 - $193.78
Q2 2018	2,749	$467	$155.01	$144.07 - $172.00
Q1 2018	2,749	$448	$163.34	$146.21 - $178.15
Q4 2017	1,813	$272	$148.07	$136.50 - $158.04
Q3 2017	1,813	$276	$150.51	$125.50 - $167.86
Q4 2015	1,664	$209	$120.72	$101.49 - $134.71
Q2 2015	1,664	$205	$125.98	$113.68 - $137.50