VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

AXA S.A.'s Holding History (CIK: 0000898427)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 171,270 Value ($000) $76,249 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 160,793 Value ($000) $77,956 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 140,790 Value ($000) $56,696 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 144,410 Value ($000) $67,162 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 193,337 Value ($000) $90,621 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 229,891 Value ($000) $96,097 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 273,361 Value ($000) $111,228 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 285,675 Value ($000) $99,341 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 275,346 Value ($000) $96,897 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 303,953 Value ($000) $95,766 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 343,690 Value ($000) $99,251 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 277,497 Value ($000) $80,346 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 233,916 Value ($000) $65,916 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 307,619 Value ($000) $80,279 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 406,199 Value ($000) $89,201 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 421,889 Value ($000) $76,526 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 222,934 Value ($000) $44,950 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 234,759 Value ($000) $50,447 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 309,085 Value ($000) $73,049 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 339,964 Value ($000) $92,511 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 471,404 Value ($000) $136,853 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 424,751 Value ($000) $101,070 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 399,106 Value ($000) $87,384 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 290,959 Value ($000) $49,294 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 460,389 Value ($000) $84,426 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 537,368 Value ($000) $98,849 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 552,659 Value ($000) $91,581 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 532,576 Value ($000) $102,648 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 804,081 Value ($000) $136,662 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 689,085 Value ($000) $112,307 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 262,114 Value ($000) $39,281 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 274,198 Value ($000) $41,689 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 171,049 Value ($000) $22,043 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 176,929 Value ($000) $19,347 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 502,788 Value ($000) $37,040 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 567,592 Value ($000) $49,500 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 630,175 Value ($000) $54,207 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 565,516 Value ($000) $44,953 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 625,338 Value ($000) $78,686 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 605,353 Value ($000) $63,041 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 524,951 Value ($000) $64,821 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 528,293 Value ($000) $62,323 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 468,849 Value ($000) $55,700 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 366,102 Value ($000) $41,116 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 358,355 Value ($000) $33,929 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 242,188 Value ($000) $17,128 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 229,575 Value ($000) $17,057 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 203,959 Value ($000) $15,464 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 166,097 Value ($000) $13,266 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	171,270	$76,249	$460.83	$416.60 - $510.77
Q1 2025	160,793	$77,956	$466.00	$397.25 - $519.68
Q4 2024	140,790	$56,696	$463.53	$377.85 - $519.88
Q3 2024	144,410	$67,162	$480.37	$456.07 - $510.64
Q2 2024	193,337	$90,621	$434.05	$391.01 - $486.43
Q1 2024	229,891	$96,097	$422.74	$403.43 - $448.40
Q4 2023	273,361	$111,228	$369.42	$341.85 - $413.00
Q3 2023	285,675	$99,341	$349.73	$335.82 - $367.00
Q2 2023	275,346	$96,897	$336.94	$313.47 - $354.94
Q1 2023	303,953	$95,766	$299.93	$282.21 - $325.19
Q4 2022	343,690	$99,251	$304.77	$283.58 - $324.75
Q3 2022	277,497	$80,346	$287.72	$271.61 - $305.95
Q2 2022	233,916	$65,916	$267.66	$233.01 - $293.17
Q1 2022	307,619	$80,279	$237.33	$214.66 - $263.58
Q4 2021	406,199	$89,201	$194.45	$176.36 - $224.49
Q3 2021	421,889	$76,526	$195.24	$180.02 - $204.88
Q2 2021	222,934	$44,950	$209.17	$185.33 - $222.78
Q1 2021	234,759	$50,447	$219.65	$204.62 - $242.99
Q4 2020	309,085	$73,049	$229.44	$202.57 - $280.99
Q3 2020	339,964	$92,511	$275.88	$253.97 - $306.08
Q2 2020	471,404	$136,853	$271.12	$222.39 - $299.21
Q1 2020	424,751	$101,070	$229.39	$197.47 - $249.85
Q4 2019	399,106	$87,384	$202.38	$165.23 - $225.66
Q3 2019	290,959	$49,294	$176.91	$165.27 - $188.44
Q2 2019	460,389	$84,426	$174.82	$163.68 - $191.71
Q1 2019	537,368	$98,849	$184.70	$160.95 - $195.81
Q4 2018	552,659	$91,581	$173.27	$151.80 - $194.92
Q3 2018	532,576	$102,648	$178.07	$164.70 - $193.78
Q2 2018	804,081	$136,662	$155.01	$144.07 - $172.00
Q1 2018	689,085	$112,307	$163.34	$146.21 - $178.15
Q4 2017	262,114	$39,281	$148.07	$136.50 - $158.04
Q3 2017	274,198	$41,689	$150.51	$125.50 - $167.86
Q2 2017	171,049	$22,043	$120.38	$107.24 - $137.26
Q1 2017	176,929	$19,347	$88.04	$73.34 - $111.88
Q4 2016	502,788	$37,040	$81.37	$71.46 - $97.93
Q3 2016	567,592	$49,500	$94.50	$83.50 - $103.73
Q2 2016	630,175	$54,207	$86.41	$75.92 - $96.49
Q1 2016	565,516	$44,953	$90.45	$75.90 - $124.96
Q4 2015	625,338	$78,686	$120.72	$101.49 - $134.71
Q3 2015	605,353	$63,041	$128.47	$97.45 - $143.45
Q2 2015	524,951	$64,821	$125.98	$113.68 - $137.50
Q1 2015	528,293	$62,323	$119.81	$103.75 - $136.33
Q4 2014	468,849	$55,700	$112.63	$96.43 - $124.35
Q3 2014	366,102	$41,116	$95.21	$84.41 - $116.88
Q2 2014	358,355	$33,929	$70.12	$59.79 - $98.80
Q1 2014	242,188	$17,128	$79.20	$67.49 - $87.77
Q4 2013	229,575	$17,057	$69.64	$58.06 - $78.38
Q3 2013	203,959	$15,464	$79.58	$73.43 - $89.96
Q2 2013	166,097	$13,266	$73.64	$51.28 - $87.47