VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

BLAIR WILLIAM & CO/IL's Holding History (CIK: 0000902367)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 16,090 Value ($000) $7,294 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 17,990 Value ($000) $7,046 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 26,077 Value ($000) $11,610 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 26,845 Value ($000) $13,015 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 26,644 Value ($000) $10,730 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 91,316 Value ($000) $42,469 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 89,108 Value ($000) $41,767 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 70,911 Value ($000) $29,642 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 63,974 Value ($000) $26,030 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 18,846 Value ($000) $6,554 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 18,265 Value ($000) $6,428 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 18,192 Value ($000) $5,732 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 17,644 Value ($000) $5,095 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 17,813 Value ($000) $5,158 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 17,955 Value ($000) $5,060 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 18,533 Value ($000) $4,837 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 23,489 Value ($000) $5,158 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 16,250 Value ($000) $2,948 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 22,750 Value ($000) $4,587 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 26,039 Value ($000) $5,596 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 28,409 Value ($000) $6,714 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 32,725 Value ($000) $8,905 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 32,742 Value ($000) $9,505 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 27,423 Value ($000) $6,525 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 27,288 Value ($000) $5,975 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 22,343 Value ($000) $3,785 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 23,726 Value ($000) $4,351 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 18,259 Value ($000) $3,359 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 7,932 Value ($000) $1,314 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 6,263 Value ($000) $1,207 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 6,216 Value ($000) $1,056 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 6,059 Value ($000) $987 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 6,017 Value ($000) $902 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 6,003 Value ($000) $913 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 6,011 Value ($000) $775 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 6,011 Value ($000) $645 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 6,121 Value ($000) $451 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 7,270 Value ($000) $634 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 7,273 Value ($000) $626 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 6,964 Value ($000) $553 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 6,399 Value ($000) $805 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 14,295 Value ($000) $1,488 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 6,469 Value ($000) $798 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 6,469 Value ($000) $762 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 6,894 Value ($000) $818 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 6,270 Value ($000) $704 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 6,236 Value ($000) $590 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 6,934 Value ($000) $490 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 6,590 Value ($000) $490 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 7,655 Value ($000) $580 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 9,570 Value ($000) $764 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	16,090	$7,294	$431.03	$392.50 - $464.44
Q3 2025	17,990	$7,046	$417.92	$362.50 - $484.56
Q2 2025	26,077	$11,610	$460.83	$416.60 - $510.77
Q1 2025	26,845	$13,015	$466.00	$397.25 - $519.68
Q4 2024	26,644	$10,730	$463.53	$377.85 - $519.88
Q3 2024	91,316	$42,469	$480.37	$456.07 - $510.64
Q2 2024	89,108	$41,767	$434.05	$391.01 - $486.43
Q1 2024	70,911	$29,642	$422.74	$403.43 - $448.40
Q4 2023	63,974	$26,030	$369.42	$341.85 - $413.00
Q3 2023	18,846	$6,554	$349.73	$335.82 - $367.00
Q2 2023	18,265	$6,428	$336.94	$313.47 - $354.94
Q1 2023	18,192	$5,732	$299.93	$282.21 - $325.19
Q4 2022	17,644	$5,095	$304.77	$283.58 - $324.75
Q3 2022	17,813	$5,158	$287.72	$271.61 - $305.95
Q2 2022	17,955	$5,060	$267.66	$233.01 - $293.17
Q1 2022	18,533	$4,837	$237.33	$214.66 - $263.58
Q4 2021	23,489	$5,158	$194.45	$176.36 - $224.49
Q3 2021	16,250	$2,948	$195.24	$180.02 - $204.88
Q2 2021	22,750	$4,587	$209.17	$185.33 - $222.78
Q1 2021	26,039	$5,596	$219.65	$204.62 - $242.99
Q4 2020	28,409	$6,714	$229.44	$202.57 - $280.99
Q3 2020	32,725	$8,905	$275.88	$253.97 - $306.08
Q2 2020	32,742	$9,505	$271.12	$222.39 - $299.21
Q1 2020	27,423	$6,525	$229.39	$197.47 - $249.85
Q4 2019	27,288	$5,975	$202.38	$165.23 - $225.66
Q3 2019	22,343	$3,785	$176.91	$165.27 - $188.44
Q2 2019	23,726	$4,351	$174.82	$163.68 - $191.71
Q1 2019	18,259	$3,359	$184.70	$160.95 - $195.81
Q4 2018	7,932	$1,314	$173.27	$151.80 - $194.92
Q3 2018	6,263	$1,207	$178.07	$164.70 - $193.78
Q2 2018	6,216	$1,056	$155.01	$144.07 - $172.00
Q1 2018	6,059	$987	$163.34	$146.21 - $178.15
Q4 2017	6,017	$902	$148.07	$136.50 - $158.04
Q3 2017	6,003	$913	$150.51	$125.50 - $167.86
Q2 2017	6,011	$775	$120.38	$107.24 - $137.26
Q1 2017	6,011	$645	$88.04	$73.34 - $111.88
Q4 2016	6,121	$451	$81.37	$71.46 - $97.93
Q3 2016	7,270	$634	$94.50	$83.50 - $103.73
Q2 2016	7,273	$626	$86.41	$75.92 - $96.49
Q1 2016	6,964	$553	$90.45	$75.90 - $124.96
Q4 2015	6,399	$805	$120.72	$101.49 - $134.71
Q3 2015	14,295	$1,488	$128.47	$97.45 - $143.45
Q2 2015	6,469	$798	$125.98	$113.68 - $137.50
Q1 2015	6,469	$762	$119.81	$103.75 - $136.33
Q4 2014	6,894	$818	$112.63	$96.43 - $124.35
Q3 2014	6,270	$704	$95.21	$84.41 - $116.88
Q2 2014	6,236	$590	$70.12	$59.79 - $98.80
Q1 2014	6,934	$490	$79.20	$67.49 - $87.77
Q4 2013	6,590	$490	$69.64	$58.06 - $78.38
Q3 2013	7,655	$580	$79.58	$73.43 - $89.96
Q2 2013	9,570	$764	$73.64	$51.28 - $87.47