VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

BANK OF MONTREAL /CAN/'s Holding History (CIK: 0000927971)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 427,480 Value ($000) $193,802 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 419,458 Value ($000) $164,277 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 363,035 Value ($000) $161,623 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 413,687 Value ($000) $200,564 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 581,181 Value ($000) $234,042 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 557,217 Value ($000) $257,925 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 511,428 Value ($000) $242,642 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 507,102 Value ($000) $212,461 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 574,127 Value ($000) $235,197 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 523,354 Value ($000) $183,582 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 477,915 Value ($000) $168,446 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 437,438 Value ($000) $137,959 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 368,001 Value ($000) $107,206 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 275,454 Value ($000) $80,954 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 376,405 Value ($000) $105,770 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 371,473 Value ($000) $95,958 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 341,874 Value ($000) $76,090 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,053,359 Value ($000) $192,016 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 938,824 Value ($000) $184,854 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 815,377 Value ($000) $171,458 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 472,962 Value ($000) $110,976 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 383,934 Value ($000) $100,200 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 471,835 Value ($000) $139,381 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 487,434 Value ($000) $118,037 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 518,468 Value ($000) $113,518 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 357,182 Value ($000) $60,514 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 334,605 Value ($000) $61,359 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 294,213 Value ($000) $54,121 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 286,725 Value ($000) $47,513 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 309,881 Value ($000) $59,726 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 251,143 Value ($000) $42,685 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 525,915 Value ($000) $85,714 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 348,499 Value ($000) $52,226 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 309,543 Value ($000) $47,063 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 208,167 Value ($000) $26,825 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 158,740 Value ($000) $17,360 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 148,580 Value ($000) $12,127 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 173,056 Value ($000) $15,093 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 172,934 Value ($000) $14,876 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 172,792 Value ($000) $13,736 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 153,728 Value ($000) $19,342 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 132,486 Value ($000) $13,797 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 141,024 Value ($000) $17,415 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 129,922 Value ($000) $15,326 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 258,253 Value ($000) $30,681 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 306,917 Value ($000) $34,469 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 74,558 Value ($000) $7,059 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 49,161 Value ($000) $3,477 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 39,082 Value ($000) $2,903 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 36,085 Value ($000) $2,736 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 74,648 Value ($000) $5,977 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	427,480	$193,802	$431.03	$392.50 - $464.44
Q3 2025	419,458	$164,277	$417.92	$362.50 - $484.56
Q2 2025	363,035	$161,623	$460.83	$416.60 - $510.77
Q1 2025	413,687	$200,564	$466.00	$397.25 - $519.68
Q4 2024	581,181	$234,042	$463.53	$377.85 - $519.88
Q3 2024	557,217	$257,925	$480.37	$456.07 - $510.64
Q2 2024	511,428	$242,642	$434.05	$391.01 - $486.43
Q1 2024	507,102	$212,461	$422.74	$403.43 - $448.40
Q4 2023	574,127	$235,197	$369.42	$341.85 - $413.00
Q3 2023	523,354	$183,582	$349.73	$335.82 - $367.00
Q2 2023	477,915	$168,446	$336.94	$313.47 - $354.94
Q1 2023	437,438	$137,959	$299.93	$282.21 - $325.19
Q4 2022	368,001	$107,206	$304.77	$283.58 - $324.75
Q3 2022	275,454	$80,954	$287.72	$271.61 - $305.95
Q2 2022	376,405	$105,770	$267.66	$233.01 - $293.17
Q1 2022	371,473	$95,958	$237.33	$214.66 - $263.58
Q4 2021	341,874	$76,090	$194.45	$176.36 - $224.49
Q3 2021	1,053,359	$192,016	$195.24	$180.02 - $204.88
Q2 2021	938,824	$184,854	$209.17	$185.33 - $222.78
Q1 2021	815,377	$171,458	$219.65	$204.62 - $242.99
Q4 2020	472,962	$110,976	$229.44	$202.57 - $280.99
Q3 2020	383,934	$100,200	$275.88	$253.97 - $306.08
Q2 2020	471,835	$139,381	$271.12	$222.39 - $299.21
Q1 2020	487,434	$118,037	$229.39	$197.47 - $249.85
Q4 2019	518,468	$113,518	$202.38	$165.23 - $225.66
Q3 2019	357,182	$60,514	$176.91	$165.27 - $188.44
Q2 2019	334,605	$61,359	$174.82	$163.68 - $191.71
Q1 2019	294,213	$54,121	$184.70	$160.95 - $195.81
Q4 2018	286,725	$47,513	$173.27	$151.80 - $194.92
Q3 2018	309,881	$59,726	$178.07	$164.70 - $193.78
Q2 2018	251,143	$42,685	$155.01	$144.07 - $172.00
Q1 2018	525,915	$85,714	$163.34	$146.21 - $178.15
Q4 2017	348,499	$52,226	$148.07	$136.50 - $158.04
Q3 2017	309,543	$47,063	$150.51	$125.50 - $167.86
Q2 2017	208,167	$26,825	$120.38	$107.24 - $137.26
Q1 2017	158,740	$17,360	$88.04	$73.34 - $111.88
Q4 2016	148,580	$12,127	$81.37	$71.46 - $97.93
Q3 2016	173,056	$15,093	$94.50	$83.50 - $103.73
Q2 2016	172,934	$14,876	$86.41	$75.92 - $96.49
Q1 2016	172,792	$13,736	$90.45	$75.90 - $124.96
Q4 2015	153,728	$19,342	$120.72	$101.49 - $134.71
Q3 2015	132,486	$13,797	$128.47	$97.45 - $143.45
Q2 2015	141,024	$17,415	$125.98	$113.68 - $137.50
Q1 2015	129,922	$15,326	$119.81	$103.75 - $136.33
Q4 2014	258,253	$30,681	$112.63	$96.43 - $124.35
Q3 2014	306,917	$34,469	$95.21	$84.41 - $116.88
Q2 2014	74,558	$7,059	$70.12	$59.79 - $98.80
Q1 2014	49,161	$3,477	$79.20	$67.49 - $87.77
Q4 2013	39,082	$2,903	$69.64	$58.06 - $78.38
Q3 2013	36,085	$2,736	$79.58	$73.43 - $89.96
Q2 2013	74,648	$5,977	$73.64	$51.28 - $87.47