VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 557,713 Value ($000) $252,880 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 510,165 Value ($000) $199,801 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 546,956 Value ($000) $243,505 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 546,904 Value ($000) $265,150 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 545,366 Value ($000) $219,619 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 622,225 Value ($000) $289,384 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 633,575 Value ($000) $296,969 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 695,825 Value ($000) $290,862 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 818,803 Value ($000) $333,163 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 881,505 Value ($000) $306,535 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 928,417 Value ($000) $326,719 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 912,286 Value ($000) $287,434 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 838,863 Value ($000) $242,296 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 751,883 Value ($000) $218,257 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 749,795 Value ($000) $211,043 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 638,594 Value ($000) $165,934 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 476,920 Value ($000) $105,341 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 592,967 Value ($000) $107,558 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 598,740 Value ($000) $120,723 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 608,555 Value ($000) $130,773 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 428,708 Value ($000) $101,320 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 245,276 Value ($000) $66,744 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 276,726 Value ($000) $78,916 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 279,654 Value ($000) $66,544 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 241,299 Value ($000) $52,833 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 248,368 Value ($000) $41,412 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 238,963 Value ($000) $43,821 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 261,292 Value ($000) $48,064 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 303,279 Value ($000) $50,257 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 316,649 Value ($000) $61,031 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 271,907 Value ($000) $46,213 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 248,213 Value ($000) $40,453 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 313,381 Value ($000) $46,964 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 279,767 Value ($000) $42,536 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 274,237 Value ($000) $35,341 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 270,966 Value ($000) $29,630 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 258,390 Value ($000) $19,035 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 374,053 Value ($000) $32,621 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 421,872 Value ($000) $36,289 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 522,537 Value ($000) $40,967 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 246,101 Value ($000) $30,967 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 255,098 Value ($000) $26,566 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 246,020 Value ($000) $30,379 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 247,867 Value ($000) $29,241 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 253,063 Value ($000) $30,064 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 240,800 Value ($000) $27,045 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 240,152 Value ($000) $22,737 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 233,929 Value ($000) $16,544 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 227,205 Value ($000) $16,880 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 251,684 Value ($000) $19,082 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 278,795 Value ($000) $22,268 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	557,713	$252,880	$431.03	$392.50 - $464.44
Q3 2025	510,165	$199,801	$417.92	$362.50 - $484.56
Q2 2025	546,956	$243,505	$460.83	$416.60 - $510.77
Q1 2025	546,904	$265,150	$466.00	$397.25 - $519.68
Q4 2024	545,366	$219,619	$463.53	$377.85 - $519.88
Q3 2024	622,225	$289,384	$480.37	$456.07 - $510.64
Q2 2024	633,575	$296,969	$434.05	$391.01 - $486.43
Q1 2024	695,825	$290,862	$422.74	$403.43 - $448.40
Q4 2023	818,803	$333,163	$369.42	$341.85 - $413.00
Q3 2023	881,505	$306,535	$349.73	$335.82 - $367.00
Q2 2023	928,417	$326,719	$336.94	$313.47 - $354.94
Q1 2023	912,286	$287,434	$299.93	$282.21 - $325.19
Q4 2022	838,863	$242,296	$304.77	$283.58 - $324.75
Q3 2022	751,883	$218,257	$287.72	$271.61 - $305.95
Q2 2022	749,795	$211,043	$267.66	$233.01 - $293.17
Q1 2022	638,594	$165,934	$237.33	$214.66 - $263.58
Q4 2021	476,920	$105,341	$194.45	$176.36 - $224.49
Q3 2021	592,967	$107,558	$195.24	$180.02 - $204.88
Q2 2021	598,740	$120,723	$209.17	$185.33 - $222.78
Q1 2021	608,555	$130,773	$219.65	$204.62 - $242.99
Q4 2020	428,708	$101,320	$229.44	$202.57 - $280.99
Q3 2020	245,276	$66,744	$275.88	$253.97 - $306.08
Q2 2020	276,726	$78,916	$271.12	$222.39 - $299.21
Q1 2020	279,654	$66,544	$229.39	$197.47 - $249.85
Q4 2019	241,299	$52,833	$202.38	$165.23 - $225.66
Q3 2019	248,368	$41,412	$176.91	$165.27 - $188.44
Q2 2019	238,963	$43,821	$174.82	$163.68 - $191.71
Q1 2019	261,292	$48,064	$184.70	$160.95 - $195.81
Q4 2018	303,279	$50,257	$173.27	$151.80 - $194.92
Q3 2018	316,649	$61,031	$178.07	$164.70 - $193.78
Q2 2018	271,907	$46,213	$155.01	$144.07 - $172.00
Q1 2018	248,213	$40,453	$163.34	$146.21 - $178.15
Q4 2017	313,381	$46,964	$148.07	$136.50 - $158.04
Q3 2017	279,767	$42,536	$150.51	$125.50 - $167.86
Q2 2017	274,237	$35,341	$120.38	$107.24 - $137.26
Q1 2017	270,966	$29,630	$88.04	$73.34 - $111.88
Q4 2016	258,390	$19,035	$81.37	$71.46 - $97.93
Q3 2016	374,053	$32,621	$94.50	$83.50 - $103.73
Q2 2016	421,872	$36,289	$86.41	$75.92 - $96.49
Q1 2016	522,537	$40,967	$90.45	$75.90 - $124.96
Q4 2015	246,101	$30,967	$120.72	$101.49 - $134.71
Q3 2015	255,098	$26,566	$128.47	$97.45 - $143.45
Q2 2015	246,020	$30,379	$125.98	$113.68 - $137.50
Q1 2015	247,867	$29,241	$119.81	$103.75 - $136.33
Q4 2014	253,063	$30,064	$112.63	$96.43 - $124.35
Q3 2014	240,800	$27,045	$95.21	$84.41 - $116.88
Q2 2014	240,152	$22,737	$70.12	$59.79 - $98.80
Q1 2014	233,929	$16,544	$79.20	$67.49 - $87.77
Q4 2013	227,205	$16,880	$69.64	$58.06 - $78.38
Q3 2013	251,684	$19,082	$79.58	$73.43 - $89.96
Q2 2013	278,795	$22,268	$73.64	$51.28 - $87.47