VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Fayez Sarofim & Co's Holding History (CIK: 0000937729)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 10,000 Value ($000) $4,534 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 10,058 Value ($000) $3,939 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 10,358 Value ($000) $4,611 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 10,392 Value ($000) $5,038 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 10,392 Value ($000) $4,185 Avg Close $463.53 Range $377.85 - $519.88

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	10,000	$4,534	$431.03	$392.50 - $464.44
Q3 2025	10,058	$3,939	$417.92	$362.50 - $484.56
Q2 2025	10,358	$4,611	$460.83	$416.60 - $510.77
Q1 2025	10,392	$5,038	$466.00	$397.25 - $519.68
Q4 2024	10,392	$4,185	$463.53	$377.85 - $519.88