VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM's Holding History (CIK: 0000938076)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 226,000 Value ($000) $102,459 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 233,612 Value ($000) $91,492 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 251,011 Value ($000) $111,750 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 248,709 Value ($000) $120,579 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 248,049 Value ($000) $99,889 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 261,575 Value ($000) $121,653 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 266,540 Value ($000) $124,933 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 305,875 Value ($000) $96,372 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 287,550 Value ($000) $117,001 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 299,409 Value ($000) $104,116 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 294,796 Value ($000) $103,742 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 305,875 Value ($000) $96,372 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 308,815 Value ($000) $89,180 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 311,075 Value ($000) $90,069 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 315,475 Value ($000) $88,898 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 314,393 Value ($000) $82,047 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 324,362 Value ($000) $71,230 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 326,776 Value ($000) $59,274 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 334,640 Value ($000) $67,473 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 333,966 Value ($000) $71,766 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 349,136 Value ($000) $82,515 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 354,815 Value ($000) $96,552 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 354,488 Value ($000) $102,911 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 346,113 Value ($000) $82,358 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 336,000 Value ($000) $73,567 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 337,524 Value ($000) $57,183 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 338,051 Value ($000) $61,992 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 345,432 Value ($000) $63,542 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 345,392 Value ($000) $57,235 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 349,122 Value ($000) $67,290 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 351,035 Value ($000) $59,662 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 351,957 Value ($000) $57,362 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 361,352 Value ($000) $54,152 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 368,645 Value ($000) $56,049 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 368,155 Value ($000) $47,444 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 365,937 Value ($000) $40,015 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 367,755 Value ($000) $27,093 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 366,918 Value ($000) $31,999 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 367,922 Value ($000) $31,649 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 305,309 Value ($000) $24,269 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 309,584 Value ($000) $38,955 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 313,929 Value ($000) $32,693 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 310,142 Value ($000) $38,296 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 316,287 Value ($000) $37,312 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 350,241 Value ($000) $41,609 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 355,258 Value ($000) $39,899 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 365,496 Value ($000) $34,605 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 361,140 Value ($000) $25,540 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 392,400 Value ($000) $29,155 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 386,537 Value ($000) $29,307 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 386,503 Value ($000) $30,870 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	226,000	$102,459	$431.03	$392.50 - $464.44
Q3 2025	233,612	$91,492	$417.92	$362.50 - $484.56
Q2 2025	251,011	$111,750	$460.83	$416.60 - $510.77
Q1 2025	248,709	$120,579	$466.00	$397.25 - $519.68
Q4 2024	248,049	$99,889	$463.53	$377.85 - $519.88
Q3 2024	261,575	$121,653	$480.37	$456.07 - $510.64
Q2 2024	266,540	$124,933	$434.05	$391.01 - $486.43
Q1 2024	305,875	$96,372	$422.74	$403.43 - $448.40
Q4 2023	287,550	$117,001	$369.42	$341.85 - $413.00
Q3 2023	299,409	$104,116	$349.73	$335.82 - $367.00
Q2 2023	294,796	$103,742	$336.94	$313.47 - $354.94
Q1 2023	305,875	$96,372	$299.93	$282.21 - $325.19
Q4 2022	308,815	$89,180	$304.77	$283.58 - $324.75
Q3 2022	311,075	$90,069	$287.72	$271.61 - $305.95
Q2 2022	315,475	$88,898	$267.66	$233.01 - $293.17
Q1 2022	314,393	$82,047	$237.33	$214.66 - $263.58
Q4 2021	324,362	$71,230	$194.45	$176.36 - $224.49
Q3 2021	326,776	$59,274	$195.24	$180.02 - $204.88
Q2 2021	334,640	$67,473	$209.17	$185.33 - $222.78
Q1 2021	333,966	$71,766	$219.65	$204.62 - $242.99
Q4 2020	349,136	$82,515	$229.44	$202.57 - $280.99
Q3 2020	354,815	$96,552	$275.88	$253.97 - $306.08
Q2 2020	354,488	$102,911	$271.12	$222.39 - $299.21
Q1 2020	346,113	$82,358	$229.39	$197.47 - $249.85
Q4 2019	336,000	$73,567	$202.38	$165.23 - $225.66
Q3 2019	337,524	$57,183	$176.91	$165.27 - $188.44
Q2 2019	338,051	$61,992	$174.82	$163.68 - $191.71
Q1 2019	345,432	$63,542	$184.70	$160.95 - $195.81
Q4 2018	345,392	$57,235	$173.27	$151.80 - $194.92
Q3 2018	349,122	$67,290	$178.07	$164.70 - $193.78
Q2 2018	351,035	$59,662	$155.01	$144.07 - $172.00
Q1 2018	351,957	$57,362	$163.34	$146.21 - $178.15
Q4 2017	361,352	$54,152	$148.07	$136.50 - $158.04
Q3 2017	368,645	$56,049	$150.51	$125.50 - $167.86
Q2 2017	368,155	$47,444	$120.38	$107.24 - $137.26
Q1 2017	365,937	$40,015	$88.04	$73.34 - $111.88
Q4 2016	367,755	$27,093	$81.37	$71.46 - $97.93
Q3 2016	366,918	$31,999	$94.50	$83.50 - $103.73
Q2 2016	367,922	$31,649	$86.41	$75.92 - $96.49
Q1 2016	305,309	$24,269	$90.45	$75.90 - $124.96
Q4 2015	309,584	$38,955	$120.72	$101.49 - $134.71
Q3 2015	313,929	$32,693	$128.47	$97.45 - $143.45
Q2 2015	310,142	$38,296	$125.98	$113.68 - $137.50
Q1 2015	316,287	$37,312	$119.81	$103.75 - $136.33
Q4 2014	350,241	$41,609	$112.63	$96.43 - $124.35
Q3 2014	355,258	$39,899	$95.21	$84.41 - $116.88
Q2 2014	365,496	$34,605	$70.12	$59.79 - $98.80
Q1 2014	361,140	$25,540	$79.20	$67.49 - $87.77
Q4 2013	392,400	$29,155	$69.64	$58.06 - $78.38
Q3 2013	386,537	$29,307	$79.58	$73.43 - $89.96
Q2 2013	386,503	$30,870	$73.64	$51.28 - $87.47