VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 3,343 Value ($000) $1,309 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 20,081 Value ($000) $8,940 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 71,933 Value ($000) $34,875 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 265,684 Value ($000) $106,991 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 138,408 Value ($000) $64,371 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 170,063 Value ($000) $79,712 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 355,458 Value ($000) $148,585 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 212,981 Value ($000) $86,660 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 256,993 Value ($000) $89,367 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 251,758 Value ($000) $88,596 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 204,932 Value ($000) $64,568 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 110,533 Value ($000) $31,920 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 118,253 Value ($000) $34,239 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 278,744 Value ($000) $78,547 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 744,248 Value ($000) $194,226 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 1,021,323 Value ($000) $224,283 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,714,634 Value ($000) $311,017 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 777,015 Value ($000) $156,669 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 546,624 Value ($000) $117,464 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 874,348 Value ($000) $206,644 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 351,138 Value ($000) $95,552 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 147,830 Value ($000) $42,916 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 297,187 Value ($000) $70,716 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 373,973 Value ($000) $81,881 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 698,668 Value ($000) $118,368 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 869,909 Value ($000) $159,524 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,003,229 Value ($000) $184,544 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,168,601 Value ($000) $193,649 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,265,356 Value ($000) $243,885 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 1,101,590 Value ($000) $187,227 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 959,061 Value ($000) $156,308 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 419,650 Value ($000) $62,889 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 324,089 Value ($000) $49,275 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 808,986 Value ($000) $104,254 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 574,485 Value ($000) $62,820 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 637,583 Value ($000) $46,970 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 448,011 Value ($000) $39,071 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 976,050 Value ($000) $83,960 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,146,335 Value ($000) $91,122 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 662,524 Value ($000) $83,366 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 378,153 Value ($000) $39,381 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 800,087 Value ($000) $98,795 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 1,117,031 Value ($000) $131,776 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 1,010,459 Value ($000) $120,042 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 428,021 Value ($000) $48,071 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 924,025 Value ($000) $87,486 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 1,897,799 Value ($000) $134,212 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 722,340 Value ($000) $53,670 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 233,402 Value ($000) $17,696 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 305,517 Value ($000) $24,401 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	3,343	$1,309	$417.92	$362.50 - $484.56
Q2 2025	20,081	$8,940	$460.83	$416.60 - $510.77
Q1 2025	71,933	$34,875	$466.00	$397.25 - $519.68
Q4 2024	265,684	$106,991	$463.53	$377.85 - $519.88
Q3 2024	138,408	$64,371	$480.37	$456.07 - $510.64
Q2 2024	170,063	$79,712	$434.05	$391.01 - $486.43
Q1 2024	355,458	$148,585	$422.74	$403.43 - $448.40
Q4 2023	212,981	$86,660	$369.42	$341.85 - $413.00
Q3 2023	256,993	$89,367	$349.73	$335.82 - $367.00
Q2 2023	251,758	$88,596	$336.94	$313.47 - $354.94
Q1 2023	204,932	$64,568	$299.93	$282.21 - $325.19
Q4 2022	110,533	$31,920	$304.77	$283.58 - $324.75
Q3 2022	118,253	$34,239	$287.72	$271.61 - $305.95
Q2 2022	278,744	$78,547	$267.66	$233.01 - $293.17
Q1 2022	744,248	$194,226	$237.33	$214.66 - $263.58
Q4 2021	1,021,323	$224,283	$194.45	$176.36 - $224.49
Q3 2021	1,714,634	$311,017	$195.24	$180.02 - $204.88
Q2 2021	777,015	$156,669	$209.17	$185.33 - $222.78
Q1 2021	546,624	$117,464	$219.65	$204.62 - $242.99
Q4 2020	874,348	$206,644	$229.44	$202.57 - $280.99
Q3 2020	351,138	$95,552	$275.88	$253.97 - $306.08
Q2 2020	147,830	$42,916	$271.12	$222.39 - $299.21
Q1 2020	297,187	$70,716	$229.39	$197.47 - $249.85
Q4 2019	373,973	$81,881	$202.38	$165.23 - $225.66
Q3 2019	698,668	$118,368	$176.91	$165.27 - $188.44
Q2 2019	869,909	$159,524	$174.82	$163.68 - $191.71
Q1 2019	1,003,229	$184,544	$184.70	$160.95 - $195.81
Q4 2018	1,168,601	$193,649	$173.27	$151.80 - $194.92
Q3 2018	1,265,356	$243,885	$178.07	$164.70 - $193.78
Q2 2018	1,101,590	$187,227	$155.01	$144.07 - $172.00
Q1 2018	959,061	$156,308	$163.34	$146.21 - $178.15
Q4 2017	419,650	$62,889	$148.07	$136.50 - $158.04
Q3 2017	324,089	$49,275	$150.51	$125.50 - $167.86
Q2 2017	808,986	$104,254	$120.38	$107.24 - $137.26
Q1 2017	574,485	$62,820	$88.04	$73.34 - $111.88
Q4 2016	637,583	$46,970	$81.37	$71.46 - $97.93
Q3 2016	448,011	$39,071	$94.50	$83.50 - $103.73
Q2 2016	976,050	$83,960	$86.41	$75.92 - $96.49
Q1 2016	1,146,335	$91,122	$90.45	$75.90 - $124.96
Q4 2015	662,524	$83,366	$120.72	$101.49 - $134.71
Q3 2015	378,153	$39,381	$128.47	$97.45 - $143.45
Q2 2015	800,087	$98,795	$125.98	$113.68 - $137.50
Q1 2015	1,117,031	$131,776	$119.81	$103.75 - $136.33
Q4 2014	1,010,459	$120,042	$112.63	$96.43 - $124.35
Q3 2014	428,021	$48,071	$95.21	$84.41 - $116.88
Q2 2014	924,025	$87,486	$70.12	$59.79 - $98.80
Q1 2014	1,897,799	$134,212	$79.20	$67.49 - $87.77
Q4 2013	722,340	$53,670	$69.64	$58.06 - $78.38
Q3 2013	233,402	$17,696	$79.58	$73.43 - $89.96
Q2 2013	305,517	$24,401	$73.64	$51.28 - $87.47