VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC's Holding History (CIK: 0001021223)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 11,645 Value ($000) $5,280 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 11,619 Value ($000) $4,551 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 12,013 Value ($000) $5,348 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 12,234 Value ($000) $5,931 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 12,274 Value ($000) $4,943 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 13,101 Value ($000) $6,093 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 13,426 Value ($000) $6,293 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 13,719 Value ($000) $5,735 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 14,202 Value ($000) $5,779 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 14,763 Value ($000) $5,134 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 14,874 Value ($000) $5,234 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 15,097 Value ($000) $4,757 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 15,093 Value ($000) $4,359 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 15,732 Value ($000) $4,555 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 10 Value ($000) $3 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 36 Value ($000) $9 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 10 Value ($000) $2 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 10 Value ($000) $2 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 10 Value ($000) $2 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 10 Value ($000) $2 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 10 Value ($000) $2 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 10 Value ($000) $3 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 27 Value ($000) $8 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 27 Value ($000) $6 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 27 Value ($000) $6 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 17 Value ($000) $3 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 17 Value ($000) $3 Avg Close $174.82 Range $163.68 - $191.71

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	11,645	$5,280	$431.03	$392.50 - $464.44
Q3 2025	11,619	$4,551	$417.92	$362.50 - $484.56
Q2 2025	12,013	$5,348	$460.83	$416.60 - $510.77
Q1 2025	12,234	$5,931	$466.00	$397.25 - $519.68
Q4 2024	12,274	$4,943	$463.53	$377.85 - $519.88
Q3 2024	13,101	$6,093	$480.37	$456.07 - $510.64
Q2 2024	13,426	$6,293	$434.05	$391.01 - $486.43
Q1 2024	13,719	$5,735	$422.74	$403.43 - $448.40
Q4 2023	14,202	$5,779	$369.42	$341.85 - $413.00
Q3 2023	14,763	$5,134	$349.73	$335.82 - $367.00
Q2 2023	14,874	$5,234	$336.94	$313.47 - $354.94
Q1 2023	15,097	$4,757	$299.93	$282.21 - $325.19
Q4 2022	15,093	$4,359	$304.77	$283.58 - $324.75
Q3 2022	15,732	$4,555	$287.72	$271.61 - $305.95
Q2 2022	10	$3	$267.66	$233.01 - $293.17
Q1 2022	36	$9	$237.33	$214.66 - $263.58
Q4 2021	10	$2	$194.45	$176.36 - $224.49
Q3 2021	10	$2	$195.24	$180.02 - $204.88
Q2 2021	10	$2	$209.17	$185.33 - $222.78
Q1 2021	10	$2	$219.65	$204.62 - $242.99
Q4 2020	10	$2	$229.44	$202.57 - $280.99
Q3 2020	10	$3	$275.88	$253.97 - $306.08
Q2 2020	27	$8	$271.12	$222.39 - $299.21
Q1 2020	27	$6	$229.39	$197.47 - $249.85
Q4 2019	27	$6	$202.38	$165.23 - $225.66
Q3 2019	17	$3	$176.91	$165.27 - $188.44
Q2 2019	17	$3	$174.82	$163.68 - $191.71