VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CIBC Asset Management Inc's Holding History (CIK: 0001021926)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 107,641 Value ($000) $48,800 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 81,005 Value ($000) $31,725 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 80,986 Value ($000) $36,055 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 85,379 Value ($000) $41,393 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 84,491 Value ($000) $34,025 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 80,102 Value ($000) $37,254 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 75,670 Value ($000) $35,468 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 76,344 Value ($000) $31,913 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 72,108 Value ($000) $29,340 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 72,101 Value ($000) $25,072 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 64,932 Value ($000) $22,850 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 65,308 Value ($000) $20,577 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 64,461 Value ($000) $18,615 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 66,038 Value ($000) $19,121 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 62,923 Value ($000) $17,731 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 67,587 Value ($000) $17,638 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 67,642 Value ($000) $14,854 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 61,337 Value ($000) $11,126 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 57,228 Value ($000) $11,539 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 54,538 Value ($000) $11,720 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 47,573 Value ($000) $11,243 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 44,552 Value ($000) $12,123 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 38,520 Value ($000) $11,183 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 37,376 Value ($000) $8,894 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 36,712 Value ($000) $8,038 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 35,291 Value ($000) $5,979 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 35,474 Value ($000) $6,505 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 34,487 Value ($000) $6,344 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 34,509 Value ($000) $5,718 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 33,908 Value ($000) $6,535 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 33,281 Value ($000) $5,656 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 31,295 Value ($000) $5,100 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 31,542 Value ($000) $4,727 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 31,852 Value ($000) $4,843 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 31,211 Value ($000) $4,022 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 30,234 Value ($000) $3,306 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 29,703 Value ($000) $2,188 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 29,288 Value ($000) $2,554 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 31,212 Value ($000) $2,685 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 30,701 Value ($000) $2,440 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 29,992 Value ($000) $3,774 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 29,979 Value ($000) $3,122 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 29,582 Value ($000) $3,653 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 28,241 Value ($000) $3,332 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 26,187 Value ($000) $3,111 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 32,985 Value ($000) $3,705 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 33,107 Value ($000) $3,135 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 34,129 Value ($000) $2,414 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 29,175 Value ($000) $2,168 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 28,466 Value ($000) $2,158 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 10,577 Value ($000) $847 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	107,641	$48,800	$431.03	$392.50 - $464.44
Q3 2025	81,005	$31,725	$417.92	$362.50 - $484.56
Q2 2025	80,986	$36,055	$460.83	$416.60 - $510.77
Q1 2025	85,379	$41,393	$466.00	$397.25 - $519.68
Q4 2024	84,491	$34,025	$463.53	$377.85 - $519.88
Q3 2024	80,102	$37,254	$480.37	$456.07 - $510.64
Q2 2024	75,670	$35,468	$434.05	$391.01 - $486.43
Q1 2024	76,344	$31,913	$422.74	$403.43 - $448.40
Q4 2023	72,108	$29,340	$369.42	$341.85 - $413.00
Q3 2023	72,101	$25,072	$349.73	$335.82 - $367.00
Q2 2023	64,932	$22,850	$336.94	$313.47 - $354.94
Q1 2023	65,308	$20,577	$299.93	$282.21 - $325.19
Q4 2022	64,461	$18,615	$304.77	$283.58 - $324.75
Q3 2022	66,038	$19,121	$287.72	$271.61 - $305.95
Q2 2022	62,923	$17,731	$267.66	$233.01 - $293.17
Q1 2022	67,587	$17,638	$237.33	$214.66 - $263.58
Q4 2021	67,642	$14,854	$194.45	$176.36 - $224.49
Q3 2021	61,337	$11,126	$195.24	$180.02 - $204.88
Q2 2021	57,228	$11,539	$209.17	$185.33 - $222.78
Q1 2021	54,538	$11,720	$219.65	$204.62 - $242.99
Q4 2020	47,573	$11,243	$229.44	$202.57 - $280.99
Q3 2020	44,552	$12,123	$275.88	$253.97 - $306.08
Q2 2020	38,520	$11,183	$271.12	$222.39 - $299.21
Q1 2020	37,376	$8,894	$229.39	$197.47 - $249.85
Q4 2019	36,712	$8,038	$202.38	$165.23 - $225.66
Q3 2019	35,291	$5,979	$176.91	$165.27 - $188.44
Q2 2019	35,474	$6,505	$174.82	$163.68 - $191.71
Q1 2019	34,487	$6,344	$184.70	$160.95 - $195.81
Q4 2018	34,509	$5,718	$173.27	$151.80 - $194.92
Q3 2018	33,908	$6,535	$178.07	$164.70 - $193.78
Q2 2018	33,281	$5,656	$155.01	$144.07 - $172.00
Q1 2018	31,295	$5,100	$163.34	$146.21 - $178.15
Q4 2017	31,542	$4,727	$148.07	$136.50 - $158.04
Q3 2017	31,852	$4,843	$150.51	$125.50 - $167.86
Q2 2017	31,211	$4,022	$120.38	$107.24 - $137.26
Q1 2017	30,234	$3,306	$88.04	$73.34 - $111.88
Q4 2016	29,703	$2,188	$81.37	$71.46 - $97.93
Q3 2016	29,288	$2,554	$94.50	$83.50 - $103.73
Q2 2016	31,212	$2,685	$86.41	$75.92 - $96.49
Q1 2016	30,701	$2,440	$90.45	$75.90 - $124.96
Q4 2015	29,992	$3,774	$120.72	$101.49 - $134.71
Q3 2015	29,979	$3,122	$128.47	$97.45 - $143.45
Q2 2015	29,582	$3,653	$125.98	$113.68 - $137.50
Q1 2015	28,241	$3,332	$119.81	$103.75 - $136.33
Q4 2014	26,187	$3,111	$112.63	$96.43 - $124.35
Q3 2014	32,985	$3,705	$95.21	$84.41 - $116.88
Q2 2014	33,107	$3,135	$70.12	$59.79 - $98.80
Q1 2014	34,129	$2,414	$79.20	$67.49 - $87.77
Q4 2013	29,175	$2,168	$69.64	$58.06 - $78.38
Q3 2013	28,466	$2,158	$79.58	$73.43 - $89.96
Q2 2013	10,577	$847	$73.64	$51.28 - $87.47