VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

GREAT WEST LIFE ASSURANCE CO /CAN/'s Holding History (CIK: 0001046192)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 187,604 Value ($000) $85 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 274,136 Value ($000) $108 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 270,712 Value ($000) $121 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 270,724 Value ($000) $131 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 269,878 Value ($000) $109 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 318,281 Value ($000) $148 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 320,284 Value ($000) $150 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 270,222 Value ($000) $113 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 278,549 Value ($000) $113 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 283,626 Value ($000) $99 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 280,828 Value ($000) $99 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 273,657 Value ($000) $86 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 278,324 Value ($000) $81 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 298,238 Value ($000) $86,211 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 299,457 Value ($000) $84,452 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 400,296 Value ($000) $110,407 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 405,622 Value ($000) $88,842 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 389,587 Value ($000) $71,144 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 388,576 Value ($000) $78,314 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 285,052 Value ($000) $60,879 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 338,389 Value ($000) $79,822 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 315,004 Value ($000) $85,677 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 289,469 Value ($000) $83,734 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 263,724 Value ($000) $63,100 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 272,496 Value ($000) $59,182 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 225,266 Value ($000) $38,193 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 228,641 Value ($000) $41,889 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 218,355 Value ($000) $40,059 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 190,727 Value ($000) $30,374 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 192,762 Value ($000) $37,194 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 216,080 Value ($000) $36,750 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 214,037 Value ($000) $34,914 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 220,985 Value ($000) $33,078 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 219,430 Value ($000) $32,890 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 229,693 Value ($000) $29,559 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 175,515 Value ($000) $19,174 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 174,233 Value ($000) $12,881 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 176,307 Value ($000) $15,365 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 171,165 Value ($000) $14,689 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 130,298 Value ($000) $10,348 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 124,746 Value ($000) $15,705 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 125,026 Value ($000) $13,035 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 120,431 Value ($000) $14,846 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 126,300 Value ($000) $14,866 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 129,271 Value ($000) $15,325 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 148,131 Value ($000) $16,681 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 127,583 Value ($000) $12,044 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 111,333 Value ($000) $7,830 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 108,895 Value ($000) $8,131 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 122,110 Value ($000) $9,239 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 28,900 Value ($000) $2,310 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	187,604	$85	$431.03	$392.50 - $464.44
Q3 2025	274,136	$108	$417.92	$362.50 - $484.56
Q2 2025	270,712	$121	$460.83	$416.60 - $510.77
Q1 2025	270,724	$131	$466.00	$397.25 - $519.68
Q4 2024	269,878	$109	$463.53	$377.85 - $519.88
Q3 2024	318,281	$148	$480.37	$456.07 - $510.64
Q2 2024	320,284	$150	$434.05	$391.01 - $486.43
Q1 2024	270,222	$113	$422.74	$403.43 - $448.40
Q4 2023	278,549	$113	$369.42	$341.85 - $413.00
Q3 2023	283,626	$99	$349.73	$335.82 - $367.00
Q2 2023	280,828	$99	$336.94	$313.47 - $354.94
Q1 2023	273,657	$86	$299.93	$282.21 - $325.19
Q4 2022	278,324	$81	$304.77	$283.58 - $324.75
Q3 2022	298,238	$86,211	$287.72	$271.61 - $305.95
Q2 2022	299,457	$84,452	$267.66	$233.01 - $293.17
Q1 2022	400,296	$110,407	$237.33	$214.66 - $263.58
Q4 2021	405,622	$88,842	$194.45	$176.36 - $224.49
Q3 2021	389,587	$71,144	$195.24	$180.02 - $204.88
Q2 2021	388,576	$78,314	$209.17	$185.33 - $222.78
Q1 2021	285,052	$60,879	$219.65	$204.62 - $242.99
Q4 2020	338,389	$79,822	$229.44	$202.57 - $280.99
Q3 2020	315,004	$85,677	$275.88	$253.97 - $306.08
Q2 2020	289,469	$83,734	$271.12	$222.39 - $299.21
Q1 2020	263,724	$63,100	$229.39	$197.47 - $249.85
Q4 2019	272,496	$59,182	$202.38	$165.23 - $225.66
Q3 2019	225,266	$38,193	$176.91	$165.27 - $188.44
Q2 2019	228,641	$41,889	$174.82	$163.68 - $191.71
Q1 2019	218,355	$40,059	$184.70	$160.95 - $195.81
Q4 2018	190,727	$30,374	$173.27	$151.80 - $194.92
Q3 2018	192,762	$37,194	$178.07	$164.70 - $193.78
Q2 2018	216,080	$36,750	$155.01	$144.07 - $172.00
Q1 2018	214,037	$34,914	$163.34	$146.21 - $178.15
Q4 2017	220,985	$33,078	$148.07	$136.50 - $158.04
Q3 2017	219,430	$32,890	$150.51	$125.50 - $167.86
Q2 2017	229,693	$29,559	$120.38	$107.24 - $137.26
Q1 2017	175,515	$19,174	$88.04	$73.34 - $111.88
Q4 2016	174,233	$12,881	$81.37	$71.46 - $97.93
Q3 2016	176,307	$15,365	$94.50	$83.50 - $103.73
Q2 2016	171,165	$14,689	$86.41	$75.92 - $96.49
Q1 2016	130,298	$10,348	$90.45	$75.90 - $124.96
Q4 2015	124,746	$15,705	$120.72	$101.49 - $134.71
Q3 2015	125,026	$13,035	$128.47	$97.45 - $143.45
Q2 2015	120,431	$14,846	$125.98	$113.68 - $137.50
Q1 2015	126,300	$14,866	$119.81	$103.75 - $136.33
Q4 2014	129,271	$15,325	$112.63	$96.43 - $124.35
Q3 2014	148,131	$16,681	$95.21	$84.41 - $116.88
Q2 2014	127,583	$12,044	$70.12	$59.79 - $98.80
Q1 2014	111,333	$7,830	$79.20	$67.49 - $87.77
Q4 2013	108,895	$8,131	$69.64	$58.06 - $78.38
Q3 2013	122,110	$9,239	$79.58	$73.43 - $89.96
Q2 2013	28,900	$2,310	$73.64	$51.28 - $87.47