VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

FEDERATED HERMES, INC.'s Holding History (CIK: 0001056288)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 77,661 Value ($000) $35,208 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 186,569 Value ($000) $73,068 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 193,959 Value ($000) $86,351 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 170,233 Value ($000) $82,532 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 189,075 Value ($000) $76,141 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 191,939 Value ($000) $89,267 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 211,642 Value ($000) $99,201 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 211,915 Value ($000) $88,583 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 205,361 Value ($000) $83,559 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 192,819 Value ($000) $67,051 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 157,448 Value ($000) $55,408 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 169,659 Value ($000) $53,454 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 151,022 Value ($000) $43,612 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 156,390 Value ($000) $45,281 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 176,391 Value ($000) $49,705 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 240,148 Value ($000) $62,672 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 267,084 Value ($000) $58,651 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 250,644 Value ($000) $45,465 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 172,064 Value ($000) $34,693 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 270,729 Value ($000) $58,177 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 330,315 Value ($000) $78,067 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 361,256 Value ($000) $98,305 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 364,535 Value ($000) $105,829 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 398,857 Value ($000) $94,907 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 408,730 Value ($000) $89,492 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 381,276 Value ($000) $64,596 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 324,730 Value ($000) $59,548 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 328,410 Value ($000) $60,411 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 253,690 Value ($000) $42,039 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 301,637 Value ($000) $58,137 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 395,854 Value ($000) $67,279 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 241,685 Value ($000) $39,390 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 49,260 Value ($000) $7,382 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 51,286 Value ($000) $7,798 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 50,514 Value ($000) $6,510 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 60,773 Value ($000) $6,645 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 108,352 Value ($000) $7,982 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 104,552 Value ($000) $9,117 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 129,885 Value ($000) $11,172 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 208,006 Value ($000) $16,534 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 653,498 Value ($000) $82,229 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 686,218 Value ($000) $71,463 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 45,664 Value ($000) $5,639 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 45,554 Value ($000) $5,374 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 7,503 Value ($000) $891 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 4,853 Value ($000) $545 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 4,849 Value ($000) $459 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 7,997 Value ($000) $566 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 138,834 Value ($000) $10,315 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 240,482 Value ($000) $18,233 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 223,380 Value ($000) $17,841 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	77,661	$35,208	$431.03	$392.50 - $464.44
Q3 2025	186,569	$73,068	$417.92	$362.50 - $484.56
Q2 2025	193,959	$86,351	$460.83	$416.60 - $510.77
Q1 2025	170,233	$82,532	$466.00	$397.25 - $519.68
Q4 2024	189,075	$76,141	$463.53	$377.85 - $519.88
Q3 2024	191,939	$89,267	$480.37	$456.07 - $510.64
Q2 2024	211,642	$99,201	$434.05	$391.01 - $486.43
Q1 2024	211,915	$88,583	$422.74	$403.43 - $448.40
Q4 2023	205,361	$83,559	$369.42	$341.85 - $413.00
Q3 2023	192,819	$67,051	$349.73	$335.82 - $367.00
Q2 2023	157,448	$55,408	$336.94	$313.47 - $354.94
Q1 2023	169,659	$53,454	$299.93	$282.21 - $325.19
Q4 2022	151,022	$43,612	$304.77	$283.58 - $324.75
Q3 2022	156,390	$45,281	$287.72	$271.61 - $305.95
Q2 2022	176,391	$49,705	$267.66	$233.01 - $293.17
Q1 2022	240,148	$62,672	$237.33	$214.66 - $263.58
Q4 2021	267,084	$58,651	$194.45	$176.36 - $224.49
Q3 2021	250,644	$45,465	$195.24	$180.02 - $204.88
Q2 2021	172,064	$34,693	$209.17	$185.33 - $222.78
Q1 2021	270,729	$58,177	$219.65	$204.62 - $242.99
Q4 2020	330,315	$78,067	$229.44	$202.57 - $280.99
Q3 2020	361,256	$98,305	$275.88	$253.97 - $306.08
Q2 2020	364,535	$105,829	$271.12	$222.39 - $299.21
Q1 2020	398,857	$94,907	$229.39	$197.47 - $249.85
Q4 2019	408,730	$89,492	$202.38	$165.23 - $225.66
Q3 2019	381,276	$64,596	$176.91	$165.27 - $188.44
Q2 2019	324,730	$59,548	$174.82	$163.68 - $191.71
Q1 2019	328,410	$60,411	$184.70	$160.95 - $195.81
Q4 2018	253,690	$42,039	$173.27	$151.80 - $194.92
Q3 2018	301,637	$58,137	$178.07	$164.70 - $193.78
Q2 2018	395,854	$67,279	$155.01	$144.07 - $172.00
Q1 2018	241,685	$39,390	$163.34	$146.21 - $178.15
Q4 2017	49,260	$7,382	$148.07	$136.50 - $158.04
Q3 2017	51,286	$7,798	$150.51	$125.50 - $167.86
Q2 2017	50,514	$6,510	$120.38	$107.24 - $137.26
Q1 2017	60,773	$6,645	$88.04	$73.34 - $111.88
Q4 2016	108,352	$7,982	$81.37	$71.46 - $97.93
Q3 2016	104,552	$9,117	$94.50	$83.50 - $103.73
Q2 2016	129,885	$11,172	$86.41	$75.92 - $96.49
Q1 2016	208,006	$16,534	$90.45	$75.90 - $124.96
Q4 2015	653,498	$82,229	$120.72	$101.49 - $134.71
Q3 2015	686,218	$71,463	$128.47	$97.45 - $143.45
Q2 2015	45,664	$5,639	$125.98	$113.68 - $137.50
Q1 2015	45,554	$5,374	$119.81	$103.75 - $136.33
Q4 2014	7,503	$891	$112.63	$96.43 - $124.35
Q3 2014	4,853	$545	$95.21	$84.41 - $116.88
Q2 2014	4,849	$459	$70.12	$59.79 - $98.80
Q1 2014	7,997	$566	$79.20	$67.49 - $87.77
Q4 2013	138,834	$10,315	$69.64	$58.06 - $78.38
Q3 2013	240,482	$18,233	$79.58	$73.43 - $89.96
Q2 2013	223,380	$17,841	$73.64	$51.28 - $87.47