VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CAPITAL INTERNATIONAL LTD /CA/'s Holding History (CIK: 0001065350)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 95,612 Value ($000) $43,347 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 121,287 Value ($000) $47,501 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 127,607 Value ($000) $56,811 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 112,546 Value ($000) $54,565 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 110,571 Value ($000) $44,527 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 99,605 Value ($000) $46,324 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 100,471 Value ($000) $47,093 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 99,556 Value ($000) $41,615 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 84,876 Value ($000) $34,535 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 81,499 Value ($000) $28,340 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 80,240 Value ($000) $28,237 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 69,713 Value ($000) $21,964 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 65,455 Value ($000) $18,902 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 70,850 Value ($000) $20,514 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 63,367 Value ($000) $17,856 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 63,256 Value ($000) $16,508 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 83,591 Value ($000) $18,357 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 73,555 Value ($000) $13,342 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 86,028 Value ($000) $17,346 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 79,884 Value ($000) $17,166 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 81,159 Value ($000) $19,181 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 82,250 Value ($000) $22,382 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 66,029 Value ($000) $19,169 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 63,025 Value ($000) $14,997 Avg Close $229.39 Range $197.47 - $249.85

Q2 2018

Shares 6,831 Value ($000) $1,161 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 6,034 Value ($000) $983 Avg Close $163.34 Range $146.21 - $178.15

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	95,612	$43,347	$431.03	$392.50 - $464.44
Q3 2025	121,287	$47,501	$417.92	$362.50 - $484.56
Q2 2025	127,607	$56,811	$460.83	$416.60 - $510.77
Q1 2025	112,546	$54,565	$466.00	$397.25 - $519.68
Q4 2024	110,571	$44,527	$463.53	$377.85 - $519.88
Q3 2024	99,605	$46,324	$480.37	$456.07 - $510.64
Q2 2024	100,471	$47,093	$434.05	$391.01 - $486.43
Q1 2024	99,556	$41,615	$422.74	$403.43 - $448.40
Q4 2023	84,876	$34,535	$369.42	$341.85 - $413.00
Q3 2023	81,499	$28,340	$349.73	$335.82 - $367.00
Q2 2023	80,240	$28,237	$336.94	$313.47 - $354.94
Q1 2023	69,713	$21,964	$299.93	$282.21 - $325.19
Q4 2022	65,455	$18,902	$304.77	$283.58 - $324.75
Q3 2022	70,850	$20,514	$287.72	$271.61 - $305.95
Q2 2022	63,367	$17,856	$267.66	$233.01 - $293.17
Q1 2022	63,256	$16,508	$237.33	$214.66 - $263.58
Q4 2021	83,591	$18,357	$194.45	$176.36 - $224.49
Q3 2021	73,555	$13,342	$195.24	$180.02 - $204.88
Q2 2021	86,028	$17,346	$209.17	$185.33 - $222.78
Q1 2021	79,884	$17,166	$219.65	$204.62 - $242.99
Q4 2020	81,159	$19,181	$229.44	$202.57 - $280.99
Q3 2020	82,250	$22,382	$275.88	$253.97 - $306.08
Q2 2020	66,029	$19,169	$271.12	$222.39 - $299.21
Q1 2020	63,025	$14,997	$229.39	$197.47 - $249.85
Q2 2018	6,831	$1,161	$155.01	$144.07 - $172.00
Q1 2018	6,034	$983	$163.34	$146.21 - $178.15