VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

COLDSTREAM CAPITAL MANAGEMENT INC's Holding History (CIK: 0001082339)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,002 Value ($000) $2,721 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 6,406 Value ($000) $2,509 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 5,874 Value ($000) $2,615 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 5,163 Value ($000) $2,503 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 4,896 Value ($000) $1,972 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 4,774 Value ($000) $2,235 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 4,222 Value ($000) $1,979 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 3,969 Value ($000) $1,659 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 3,931 Value ($000) $1,599 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 3,700 Value ($000) $1,287 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 3,614 Value ($000) $1,272 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 3,574 Value ($000) $1,126 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 3,365 Value ($000) $972 Avg Close $304.77 Range $283.58 - $324.75

Q2 2022

Shares 3,100 Value ($000) $874 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 2,627 Value ($000) $686 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 2,569 Value ($000) $564 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,357 Value ($000) $369 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 1,097 Value ($000) $221 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,069 Value ($000) $230 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,349 Value ($000) $319 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 1,134 Value ($000) $308 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,129 Value ($000) $327 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,109 Value ($000) $263 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 950 Value ($000) $208 Avg Close $202.38 Range $165.23 - $225.66

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,002	$2,721	$431.03	$392.50 - $464.44
Q3 2025	6,406	$2,509	$417.92	$362.50 - $484.56
Q2 2025	5,874	$2,615	$460.83	$416.60 - $510.77
Q1 2025	5,163	$2,503	$466.00	$397.25 - $519.68
Q4 2024	4,896	$1,972	$463.53	$377.85 - $519.88
Q3 2024	4,774	$2,235	$480.37	$456.07 - $510.64
Q2 2024	4,222	$1,979	$434.05	$391.01 - $486.43
Q1 2024	3,969	$1,659	$422.74	$403.43 - $448.40
Q4 2023	3,931	$1,599	$369.42	$341.85 - $413.00
Q3 2023	3,700	$1,287	$349.73	$335.82 - $367.00
Q2 2023	3,614	$1,272	$336.94	$313.47 - $354.94
Q1 2023	3,574	$1,126	$299.93	$282.21 - $325.19
Q4 2022	3,365	$972	$304.77	$283.58 - $324.75
Q2 2022	3,100	$874	$267.66	$233.01 - $293.17
Q1 2022	2,627	$686	$237.33	$214.66 - $263.58
Q4 2021	2,569	$564	$194.45	$176.36 - $224.49
Q3 2021	1,357	$369	$195.24	$180.02 - $204.88
Q2 2021	1,097	$221	$209.17	$185.33 - $222.78
Q1 2021	1,069	$230	$219.65	$204.62 - $242.99
Q4 2020	1,349	$319	$229.44	$202.57 - $280.99
Q3 2020	1,134	$308	$275.88	$253.97 - $306.08
Q2 2020	1,129	$327	$271.12	$222.39 - $299.21
Q1 2020	1,109	$263	$229.39	$197.47 - $249.85
Q4 2019	950	$208	$202.38	$165.23 - $225.66