VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

SIGMA INVESTMENT COUNSELORS INC's Holding History (CIK: 0001085163)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 10,021 Value ($000) $4,543 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 10,139 Value ($000) $3,971 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 9,299 Value ($000) $4,140 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 8,751 Value ($000) $4,243 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 9,002 Value ($000) $3,625 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 8,937 Value ($000) $4,156 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 8,677 Value ($000) $4,067 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 8,162 Value ($000) $3,412 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 7,252 Value ($000) $2,951 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 1,343 Value ($000) $467 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 1,269 Value ($000) $447 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 1,269 Value ($000) $400 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 1,269 Value ($000) $366 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 1,282 Value ($000) $371 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 1,291 Value ($000) $364 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 1,291 Value ($000) $337 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 2,117 Value ($000) $465 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,990 Value ($000) $361 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 1,842 Value ($000) $371 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,815 Value ($000) $390 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,549 Value ($000) $366 Avg Close $229.44 Range $202.57 - $280.99

Q2 2020

Shares 980 Value ($000) $285 Avg Close $271.12 Range $222.39 - $299.21

Q2 2019

Shares 1,177 Value ($000) $216 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,155 Value ($000) $212 Avg Close $184.70 Range $160.95 - $195.81

Q3 2018

Shares 1,169 Value ($000) $225 Avg Close $178.07 Range $164.70 - $193.78

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	10,021	$4,543	$431.03	$392.50 - $464.44
Q3 2025	10,139	$3,971	$417.92	$362.50 - $484.56
Q2 2025	9,299	$4,140	$460.83	$416.60 - $510.77
Q1 2025	8,751	$4,243	$466.00	$397.25 - $519.68
Q4 2024	9,002	$3,625	$463.53	$377.85 - $519.88
Q3 2024	8,937	$4,156	$480.37	$456.07 - $510.64
Q2 2024	8,677	$4,067	$434.05	$391.01 - $486.43
Q1 2024	8,162	$3,412	$422.74	$403.43 - $448.40
Q4 2023	7,252	$2,951	$369.42	$341.85 - $413.00
Q3 2023	1,343	$467	$349.73	$335.82 - $367.00
Q2 2023	1,269	$447	$336.94	$313.47 - $354.94
Q1 2023	1,269	$400	$299.93	$282.21 - $325.19
Q4 2022	1,269	$366	$304.77	$283.58 - $324.75
Q3 2022	1,282	$371	$287.72	$271.61 - $305.95
Q2 2022	1,291	$364	$267.66	$233.01 - $293.17
Q1 2022	1,291	$337	$237.33	$214.66 - $263.58
Q4 2021	2,117	$465	$194.45	$176.36 - $224.49
Q3 2021	1,990	$361	$195.24	$180.02 - $204.88
Q2 2021	1,842	$371	$209.17	$185.33 - $222.78
Q1 2021	1,815	$390	$219.65	$204.62 - $242.99
Q4 2020	1,549	$366	$229.44	$202.57 - $280.99
Q2 2020	980	$285	$271.12	$222.39 - $299.21
Q2 2019	1,177	$216	$174.82	$163.68 - $191.71
Q1 2019	1,155	$212	$184.70	$160.95 - $195.81
Q3 2018	1,169	$225	$178.07	$164.70 - $193.78