VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

SIG BROKERAGE, LP's Holding History (CIK: 0001094429)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 20,864 Value ($000) $9,459 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 26,390 Value ($000) $10,335 Avg Close $417.92 Range $362.50 - $484.56

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	20,864	$9,459	$431.03	$392.50 - $464.44
Q3 2025	26,390	$10,335	$417.92	$362.50 - $484.56