VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CASTLEARK MANAGEMENT LLC's Holding History (CIK: 0001106832)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 730 Value ($000) $331 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 730 Value ($000) $286 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 730 Value ($000) $325 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 47,039 Value ($000) $22,805 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 46,485 Value ($000) $18,720 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 82,725 Value ($000) $38,474 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 46,803 Value ($000) $21,938 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 730 Value ($000) $305 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 730 Value ($000) $297 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 730 Value ($000) $254 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 730 Value ($000) $257 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 730 Value ($000) $230 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 730 Value ($000) $211 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 730 Value ($000) $211 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 730 Value ($000) $206 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 730 Value ($000) $191 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 730 Value ($000) $160 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 730 Value ($000) $132 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 730 Value ($000) $147 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 730 Value ($000) $157 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 730 Value ($000) $173 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 930 Value ($000) $253 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 930 Value ($000) $270 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 105,060 Value ($000) $24,999 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 66,820 Value ($000) $14,630 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 930 Value ($000) $158 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 11,110 Value ($000) $2,037 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 26,830 Value ($000) $4,935 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 26,830 Value ($000) $4,446 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 26,830 Value ($000) $5,171 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 26,830 Value ($000) $4,560 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 26,830 Value ($000) $4,373 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 26,830 Value ($000) $4,021 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 26,830 Value ($000) $4,079 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 26,830 Value ($000) $3,458 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 26,830 Value ($000) $2,934 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 26,830 Value ($000) $1,977 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 26,830 Value ($000) $2,340 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 26,830 Value ($000) $2,308 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 26,830 Value ($000) $2,133 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 26,830 Value ($000) $3,376 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 30,830 Value ($000) $3,211 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 30,830 Value ($000) $3,807 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 30,830 Value ($000) $3,637 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 30,830 Value ($000) $3,663 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 31,830 Value ($000) $2,251 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 31,830 Value ($000) $3,014 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 31,830 Value ($000) $2,251 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 31,830 Value ($000) $2,365 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 30,830 Value ($000) $3,463 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 37,330 Value ($000) $2,989 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	730	$331	$431.03	$392.50 - $464.44
Q3 2025	730	$286	$417.92	$362.50 - $484.56
Q2 2025	730	$325	$460.83	$416.60 - $510.77
Q1 2025	47,039	$22,805	$466.00	$397.25 - $519.68
Q4 2024	46,485	$18,720	$463.53	$377.85 - $519.88
Q3 2024	82,725	$38,474	$480.37	$456.07 - $510.64
Q2 2024	46,803	$21,938	$434.05	$391.01 - $486.43
Q1 2024	730	$305	$422.74	$403.43 - $448.40
Q4 2023	730	$297	$369.42	$341.85 - $413.00
Q3 2023	730	$254	$349.73	$335.82 - $367.00
Q2 2023	730	$257	$336.94	$313.47 - $354.94
Q1 2023	730	$230	$299.93	$282.21 - $325.19
Q4 2022	730	$211	$304.77	$283.58 - $324.75
Q3 2022	730	$211	$287.72	$271.61 - $305.95
Q2 2022	730	$206	$267.66	$233.01 - $293.17
Q1 2022	730	$191	$237.33	$214.66 - $263.58
Q4 2021	730	$160	$194.45	$176.36 - $224.49
Q3 2021	730	$132	$195.24	$180.02 - $204.88
Q2 2021	730	$147	$209.17	$185.33 - $222.78
Q1 2021	730	$157	$219.65	$204.62 - $242.99
Q4 2020	730	$173	$229.44	$202.57 - $280.99
Q3 2020	930	$253	$275.88	$253.97 - $306.08
Q2 2020	930	$270	$271.12	$222.39 - $299.21
Q1 2020	105,060	$24,999	$229.39	$197.47 - $249.85
Q4 2019	66,820	$14,630	$202.38	$165.23 - $225.66
Q3 2019	930	$158	$176.91	$165.27 - $188.44
Q2 2019	11,110	$2,037	$174.82	$163.68 - $191.71
Q1 2019	26,830	$4,935	$184.70	$160.95 - $195.81
Q4 2018	26,830	$4,446	$173.27	$151.80 - $194.92
Q3 2018	26,830	$5,171	$178.07	$164.70 - $193.78
Q2 2018	26,830	$4,560	$155.01	$144.07 - $172.00
Q1 2018	26,830	$4,373	$163.34	$146.21 - $178.15
Q4 2017	26,830	$4,021	$148.07	$136.50 - $158.04
Q3 2017	26,830	$4,079	$150.51	$125.50 - $167.86
Q2 2017	26,830	$3,458	$120.38	$107.24 - $137.26
Q1 2017	26,830	$2,934	$88.04	$73.34 - $111.88
Q4 2016	26,830	$1,977	$81.37	$71.46 - $97.93
Q3 2016	26,830	$2,340	$94.50	$83.50 - $103.73
Q2 2016	26,830	$2,308	$86.41	$75.92 - $96.49
Q1 2016	26,830	$2,133	$90.45	$75.90 - $124.96
Q4 2015	26,830	$3,376	$120.72	$101.49 - $134.71
Q3 2015	30,830	$3,211	$128.47	$97.45 - $143.45
Q2 2015	30,830	$3,807	$125.98	$113.68 - $137.50
Q1 2015	30,830	$3,637	$119.81	$103.75 - $136.33
Q4 2014	30,830	$3,663	$112.63	$96.43 - $124.35
Q3 2014	31,830	$2,251	$95.21	$84.41 - $116.88
Q2 2014	31,830	$3,014	$70.12	$59.79 - $98.80
Q1 2014	31,830	$2,251	$79.20	$67.49 - $87.77
Q4 2013	31,830	$2,365	$69.64	$58.06 - $78.38
Q3 2013	30,830	$3,463	$79.58	$73.43 - $89.96
Q2 2013	37,330	$2,989	$73.64	$51.28 - $87.47