VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

ALLIANCEBERNSTEIN L.P.'s Holding History (CIK: 0001109448)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,496,482 Value ($000) $2,038,525 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 4,522,586 Value ($000) $1,771,226 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 4,378,320 Value ($000) $1,949,228 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 3,953,512 Value ($000) $1,916,742 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 3,920,020 Value ($000) $1,578,592 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 7,372,767 Value ($000) $3,428,926 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 7,221,072 Value ($000) $3,384,661 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 7,097,281 Value ($000) $2,966,734 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 7,039,738 Value ($000) $2,864,399 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 7,526,456 Value ($000) $2,617,250 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 7,535,034 Value ($000) $2,651,654 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 8,373,273 Value ($000) $2,638,167 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 9,069,580 Value ($000) $2,619,113 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 9,145,516 Value ($000) $2,647,993 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 9,300,230 Value ($000) $2,620,712 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 10,555,041 Value ($000) $2,754,549 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 10,443,771 Value ($000) $2,293,452 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 9,068,848 Value ($000) $1,644,998 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 6,378,432 Value ($000) $1,286,083 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 7,858,607 Value ($000) $1,688,736 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 7,941,761 Value ($000) $1,876,956 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 6,599,551 Value ($000) $1,795,870 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 5,785,971 Value ($000) $1,679,725 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 6,193,851 Value ($000) $1,473,827 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 6,361,633 Value ($000) $1,392,880 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 5,781,215 Value ($000) $979,453 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 5,094,403 Value ($000) $934,212 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 3,317,232 Value ($000) $610,205 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 2,930,730 Value ($000) $485,651 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 536,441 Value ($000) $103,394 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 496,105 Value ($000) $84,318 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 466,258 Value ($000) $75,991 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 471,278 Value ($000) $70,626 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 478,294 Value ($000) $72,720 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 443,652 Value ($000) $57,173 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 439,488 Value ($000) $48,058 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 453,957 Value ($000) $33,443 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 466,049 Value ($000) $40,644 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 464,691 Value ($000) $39,973 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 457,200 Value ($000) $36,343 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 460,975 Value ($000) $58,004 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 462,974 Value ($000) $48,214 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 468,916 Value ($000) $57,902 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 561,188 Value ($000) $66,203 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 632,192 Value ($000) $75,104 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 701,033 Value ($000) $78,733 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 1,378,620 Value ($000) $130,528 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 2,644,923 Value ($000) $187,049 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 2,417,641 Value ($000) $179,631 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 1,989,611 Value ($000) $150,852 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 2,480,855 Value ($000) $198,146 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,496,482	$2,038,525	$431.03	$392.50 - $464.44
Q3 2025	4,522,586	$1,771,226	$417.92	$362.50 - $484.56
Q2 2025	4,378,320	$1,949,228	$460.83	$416.60 - $510.77
Q1 2025	3,953,512	$1,916,742	$466.00	$397.25 - $519.68
Q4 2024	3,920,020	$1,578,592	$463.53	$377.85 - $519.88
Q3 2024	7,372,767	$3,428,926	$480.37	$456.07 - $510.64
Q2 2024	7,221,072	$3,384,661	$434.05	$391.01 - $486.43
Q1 2024	7,097,281	$2,966,734	$422.74	$403.43 - $448.40
Q4 2023	7,039,738	$2,864,399	$369.42	$341.85 - $413.00
Q3 2023	7,526,456	$2,617,250	$349.73	$335.82 - $367.00
Q2 2023	7,535,034	$2,651,654	$336.94	$313.47 - $354.94
Q1 2023	8,373,273	$2,638,167	$299.93	$282.21 - $325.19
Q4 2022	9,069,580	$2,619,113	$304.77	$283.58 - $324.75
Q3 2022	9,145,516	$2,647,993	$287.72	$271.61 - $305.95
Q2 2022	9,300,230	$2,620,712	$267.66	$233.01 - $293.17
Q1 2022	10,555,041	$2,754,549	$237.33	$214.66 - $263.58
Q4 2021	10,443,771	$2,293,452	$194.45	$176.36 - $224.49
Q3 2021	9,068,848	$1,644,998	$195.24	$180.02 - $204.88
Q2 2021	6,378,432	$1,286,083	$209.17	$185.33 - $222.78
Q1 2021	7,858,607	$1,688,736	$219.65	$204.62 - $242.99
Q4 2020	7,941,761	$1,876,956	$229.44	$202.57 - $280.99
Q3 2020	6,599,551	$1,795,870	$275.88	$253.97 - $306.08
Q2 2020	5,785,971	$1,679,725	$271.12	$222.39 - $299.21
Q1 2020	6,193,851	$1,473,827	$229.39	$197.47 - $249.85
Q4 2019	6,361,633	$1,392,880	$202.38	$165.23 - $225.66
Q3 2019	5,781,215	$979,453	$176.91	$165.27 - $188.44
Q2 2019	5,094,403	$934,212	$174.82	$163.68 - $191.71
Q1 2019	3,317,232	$610,205	$184.70	$160.95 - $195.81
Q4 2018	2,930,730	$485,651	$173.27	$151.80 - $194.92
Q3 2018	536,441	$103,394	$178.07	$164.70 - $193.78
Q2 2018	496,105	$84,318	$155.01	$144.07 - $172.00
Q1 2018	466,258	$75,991	$163.34	$146.21 - $178.15
Q4 2017	471,278	$70,626	$148.07	$136.50 - $158.04
Q3 2017	478,294	$72,720	$150.51	$125.50 - $167.86
Q2 2017	443,652	$57,173	$120.38	$107.24 - $137.26
Q1 2017	439,488	$48,058	$88.04	$73.34 - $111.88
Q4 2016	453,957	$33,443	$81.37	$71.46 - $97.93
Q3 2016	466,049	$40,644	$94.50	$83.50 - $103.73
Q2 2016	464,691	$39,973	$86.41	$75.92 - $96.49
Q1 2016	457,200	$36,343	$90.45	$75.90 - $124.96
Q4 2015	460,975	$58,004	$120.72	$101.49 - $134.71
Q3 2015	462,974	$48,214	$128.47	$97.45 - $143.45
Q2 2015	468,916	$57,902	$125.98	$113.68 - $137.50
Q1 2015	561,188	$66,203	$119.81	$103.75 - $136.33
Q4 2014	632,192	$75,104	$112.63	$96.43 - $124.35
Q3 2014	701,033	$78,733	$95.21	$84.41 - $116.88
Q2 2014	1,378,620	$130,528	$70.12	$59.79 - $98.80
Q1 2014	2,644,923	$187,049	$79.20	$67.49 - $87.77
Q4 2013	2,417,641	$179,631	$69.64	$58.06 - $78.38
Q3 2013	1,989,611	$150,852	$79.58	$73.43 - $89.96
Q2 2013	2,480,855	$198,146	$73.64	$51.28 - $87.47