VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

FIRST TRUST ADVISORS LP's Holding History (CIK: 0001125816)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 201,290 Value ($000) $91,257 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 188,161 Value ($000) $73,691 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 287,892 Value ($000) $128,170 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 144,808 Value ($000) $70,206 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 192,786 Value ($000) $77,635 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 575,032 Value ($000) $267,436 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 203,341 Value ($000) $95,310 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 231,197 Value ($000) $96,643 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 734,835 Value ($000) $298,997 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 798,366 Value ($000) $277,624 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 289,977 Value ($000) $102,046 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 332,786 Value ($000) $104,851 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 349,971 Value ($000) $101,065 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 360,892 Value ($000) $104,492 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 1,029,432 Value ($000) $290,084 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 440,812 Value ($000) $115,039 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 521,427 Value ($000) $114,505 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 490,671 Value ($000) $89,003 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 399,314 Value ($000) $80,518 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 387,580 Value ($000) $83,287 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 404,019 Value ($000) $95,486 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 829,763 Value ($000) $225,795 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 812,055 Value ($000) $235,748 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 495,422 Value ($000) $117,886 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 356,976 Value ($000) $78,160 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 446,434 Value ($000) $75,635 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 668,232 Value ($000) $122,540 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 737,564 Value ($000) $135,675 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 708,478 Value ($000) $117,402 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 718,455 Value ($000) $138,475 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 513,675 Value ($000) $87,304 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 476,971 Value ($000) $77,737 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 542,432 Value ($000) $81,289 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 555,021 Value ($000) $84,385 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 646,539 Value ($000) $83,319 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 403,386 Value ($000) $44,110 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 417,292 Value ($000) $30,742 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 360,273 Value ($000) $31,419 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 416,561 Value ($000) $35,833 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 433,965 Value ($000) $34,496 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 979,725 Value ($000) $123,279 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 1,023,344 Value ($000) $106,571 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 1,001,124 Value ($000) $123,619 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 850,626 Value ($000) $100,348 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 1,016,236 Value ($000) $120,729 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 883,226 Value ($000) $99,195 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 986,152 Value ($000) $93,369 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 787,573 Value ($000) $55,697 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 633,724 Value ($000) $47,086 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 660,506 Value ($000) $50,080 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 408,055 Value ($000) $32,669 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	201,290	$91,257	$431.03	$392.50 - $464.44
Q3 2025	188,161	$73,691	$417.92	$362.50 - $484.56
Q2 2025	287,892	$128,170	$460.83	$416.60 - $510.77
Q1 2025	144,808	$70,206	$466.00	$397.25 - $519.68
Q4 2024	192,786	$77,635	$463.53	$377.85 - $519.88
Q3 2024	575,032	$267,436	$480.37	$456.07 - $510.64
Q2 2024	203,341	$95,310	$434.05	$391.01 - $486.43
Q1 2024	231,197	$96,643	$422.74	$403.43 - $448.40
Q4 2023	734,835	$298,997	$369.42	$341.85 - $413.00
Q3 2023	798,366	$277,624	$349.73	$335.82 - $367.00
Q2 2023	289,977	$102,046	$336.94	$313.47 - $354.94
Q1 2023	332,786	$104,851	$299.93	$282.21 - $325.19
Q4 2022	349,971	$101,065	$304.77	$283.58 - $324.75
Q3 2022	360,892	$104,492	$287.72	$271.61 - $305.95
Q2 2022	1,029,432	$290,084	$267.66	$233.01 - $293.17
Q1 2022	440,812	$115,039	$237.33	$214.66 - $263.58
Q4 2021	521,427	$114,505	$194.45	$176.36 - $224.49
Q3 2021	490,671	$89,003	$195.24	$180.02 - $204.88
Q2 2021	399,314	$80,518	$209.17	$185.33 - $222.78
Q1 2021	387,580	$83,287	$219.65	$204.62 - $242.99
Q4 2020	404,019	$95,486	$229.44	$202.57 - $280.99
Q3 2020	829,763	$225,795	$275.88	$253.97 - $306.08
Q2 2020	812,055	$235,748	$271.12	$222.39 - $299.21
Q1 2020	495,422	$117,886	$229.39	$197.47 - $249.85
Q4 2019	356,976	$78,160	$202.38	$165.23 - $225.66
Q3 2019	446,434	$75,635	$176.91	$165.27 - $188.44
Q2 2019	668,232	$122,540	$174.82	$163.68 - $191.71
Q1 2019	737,564	$135,675	$184.70	$160.95 - $195.81
Q4 2018	708,478	$117,402	$173.27	$151.80 - $194.92
Q3 2018	718,455	$138,475	$178.07	$164.70 - $193.78
Q2 2018	513,675	$87,304	$155.01	$144.07 - $172.00
Q1 2018	476,971	$77,737	$163.34	$146.21 - $178.15
Q4 2017	542,432	$81,289	$148.07	$136.50 - $158.04
Q3 2017	555,021	$84,385	$150.51	$125.50 - $167.86
Q2 2017	646,539	$83,319	$120.38	$107.24 - $137.26
Q1 2017	403,386	$44,110	$88.04	$73.34 - $111.88
Q4 2016	417,292	$30,742	$81.37	$71.46 - $97.93
Q3 2016	360,273	$31,419	$94.50	$83.50 - $103.73
Q2 2016	416,561	$35,833	$86.41	$75.92 - $96.49
Q1 2016	433,965	$34,496	$90.45	$75.90 - $124.96
Q4 2015	979,725	$123,279	$120.72	$101.49 - $134.71
Q3 2015	1,023,344	$106,571	$128.47	$97.45 - $143.45
Q2 2015	1,001,124	$123,619	$125.98	$113.68 - $137.50
Q1 2015	850,626	$100,348	$119.81	$103.75 - $136.33
Q4 2014	1,016,236	$120,729	$112.63	$96.43 - $124.35
Q3 2014	883,226	$99,195	$95.21	$84.41 - $116.88
Q2 2014	986,152	$93,369	$70.12	$59.79 - $98.80
Q1 2014	787,573	$55,697	$79.20	$67.49 - $87.77
Q4 2013	633,724	$47,086	$69.64	$58.06 - $78.38
Q3 2013	660,506	$50,080	$79.58	$73.43 - $89.96
Q2 2013	408,055	$32,669	$73.64	$51.28 - $87.47