VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

AVIVA PLC's Holding History (CIK: 0001140022)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 216,211 Value ($000) $98,021 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 204,889 Value ($000) $80,243 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 192,660 Value ($000) $85,772 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 180,690 Value ($000) $87,602 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 155,490 Value ($000) $62,616 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 124,840 Value ($000) $58,061 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 121,917 Value ($000) $57,145 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 98,001 Value ($000) $40,965 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 126,983 Value ($000) $51,668 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 109,626 Value ($000) $38,121 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 100,810 Value ($000) $35,476 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 156,382 Value ($000) $49,271 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 152,261 Value ($000) $43,970 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 171,005 Value ($000) $49,513 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 194,821 Value ($000) $54,899 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 147,748 Value ($000) $38,558 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 93,524 Value ($000) $20,538 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 102,141 Value ($000) $18,527 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 96,116 Value ($000) $19,380 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 86,960 Value ($000) $18,687 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 87,376 Value ($000) $20,650 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 83,841 Value ($000) $22,815 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 86,553 Value ($000) $25,127 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 91,073 Value ($000) $21,671 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 90,089 Value ($000) $19,725 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 90,593 Value ($000) $15,348 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 94,141 Value ($000) $17,264 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 96,481 Value ($000) $17,748 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 96,306 Value ($000) $15,959 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 122,795 Value ($000) $23,668 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 127,148 Value ($000) $21,610 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 127,983 Value ($000) $20,859 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 140,533 Value ($000) $21,060 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 158,078 Value ($000) $24,034 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 154,658 Value ($000) $19,932 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 152,678 Value ($000) $16,695 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 161,165 Value ($000) $11,884 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 150,555 Value ($000) $13,133 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 147,269 Value ($000) $12,665 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 135,620 Value ($000) $10,780 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 134,164 Value ($000) $16,882 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 134,961 Value ($000) $14,054 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 136,769 Value ($000) $16,889 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 128,669 Value ($000) $15,179 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 96,668 Value ($000) $11,484 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 96,878 Value ($000) $10,880 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 96,958 Value ($000) $9,180 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 96,758 Value ($000) $6,843 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 91,948 Value ($000) $6,832 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 83,604 Value ($000) $6,339 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 338,392 Value ($000) $27,028 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	216,211	$98,021	$431.03	$392.50 - $464.44
Q3 2025	204,889	$80,243	$417.92	$362.50 - $484.56
Q2 2025	192,660	$85,772	$460.83	$416.60 - $510.77
Q1 2025	180,690	$87,602	$466.00	$397.25 - $519.68
Q4 2024	155,490	$62,616	$463.53	$377.85 - $519.88
Q3 2024	124,840	$58,061	$480.37	$456.07 - $510.64
Q2 2024	121,917	$57,145	$434.05	$391.01 - $486.43
Q1 2024	98,001	$40,965	$422.74	$403.43 - $448.40
Q4 2023	126,983	$51,668	$369.42	$341.85 - $413.00
Q3 2023	109,626	$38,121	$349.73	$335.82 - $367.00
Q2 2023	100,810	$35,476	$336.94	$313.47 - $354.94
Q1 2023	156,382	$49,271	$299.93	$282.21 - $325.19
Q4 2022	152,261	$43,970	$304.77	$283.58 - $324.75
Q3 2022	171,005	$49,513	$287.72	$271.61 - $305.95
Q2 2022	194,821	$54,899	$267.66	$233.01 - $293.17
Q1 2022	147,748	$38,558	$237.33	$214.66 - $263.58
Q4 2021	93,524	$20,538	$194.45	$176.36 - $224.49
Q3 2021	102,141	$18,527	$195.24	$180.02 - $204.88
Q2 2021	96,116	$19,380	$209.17	$185.33 - $222.78
Q1 2021	86,960	$18,687	$219.65	$204.62 - $242.99
Q4 2020	87,376	$20,650	$229.44	$202.57 - $280.99
Q3 2020	83,841	$22,815	$275.88	$253.97 - $306.08
Q2 2020	86,553	$25,127	$271.12	$222.39 - $299.21
Q1 2020	91,073	$21,671	$229.39	$197.47 - $249.85
Q4 2019	90,089	$19,725	$202.38	$165.23 - $225.66
Q3 2019	90,593	$15,348	$176.91	$165.27 - $188.44
Q2 2019	94,141	$17,264	$174.82	$163.68 - $191.71
Q1 2019	96,481	$17,748	$184.70	$160.95 - $195.81
Q4 2018	96,306	$15,959	$173.27	$151.80 - $194.92
Q3 2018	122,795	$23,668	$178.07	$164.70 - $193.78
Q2 2018	127,148	$21,610	$155.01	$144.07 - $172.00
Q1 2018	127,983	$20,859	$163.34	$146.21 - $178.15
Q4 2017	140,533	$21,060	$148.07	$136.50 - $158.04
Q3 2017	158,078	$24,034	$150.51	$125.50 - $167.86
Q2 2017	154,658	$19,932	$120.38	$107.24 - $137.26
Q1 2017	152,678	$16,695	$88.04	$73.34 - $111.88
Q4 2016	161,165	$11,884	$81.37	$71.46 - $97.93
Q3 2016	150,555	$13,133	$94.50	$83.50 - $103.73
Q2 2016	147,269	$12,665	$86.41	$75.92 - $96.49
Q1 2016	135,620	$10,780	$90.45	$75.90 - $124.96
Q4 2015	134,164	$16,882	$120.72	$101.49 - $134.71
Q3 2015	134,961	$14,054	$128.47	$97.45 - $143.45
Q2 2015	136,769	$16,889	$125.98	$113.68 - $137.50
Q1 2015	128,669	$15,179	$119.81	$103.75 - $136.33
Q4 2014	96,668	$11,484	$112.63	$96.43 - $124.35
Q3 2014	96,878	$10,880	$95.21	$84.41 - $116.88
Q2 2014	96,958	$9,180	$70.12	$59.79 - $98.80
Q1 2014	96,758	$6,843	$79.20	$67.49 - $87.77
Q4 2013	91,948	$6,832	$69.64	$58.06 - $78.38
Q3 2013	83,604	$6,339	$79.58	$73.43 - $89.96
Q2 2013	338,392	$27,028	$73.64	$51.28 - $87.47