VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO's Holding History (CIK: 0001141802)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,300 Value ($000) $3,763 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 8,307 Value ($000) $3,253 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 11,532 Value ($000) $5,134 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 13,037 Value ($000) $6,321 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 12,547 Value ($000) $5,053 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 12,397 Value ($000) $5,766 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 15,942 Value ($000) $7,471 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 8,295 Value ($000) $3,467 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 8,617 Value ($000) $3,506 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 8,107 Value ($000) $2,819 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 8,888 Value ($000) $3,128 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 9,662 Value ($000) $3,044 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 9,540 Value ($000) $2,755 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 9,124 Value ($000) $2,642 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 9,147 Value ($000) $2,578 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 9,580 Value ($000) $2,501 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 7,556 Value ($000) $1,660 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 5,561 Value ($000) $1,008 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 6,223 Value ($000) $1,255 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 10,224 Value ($000) $2,197 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 13,609 Value ($000) $3,217 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 11,165 Value ($000) $3,038 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 2,942 Value ($000) $855 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 2,169 Value ($000) $516 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,901 Value ($000) $416 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 2,229 Value ($000) $378 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 2,284 Value ($000) $419 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 2,162 Value ($000) $398 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,881 Value ($000) $312 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,941 Value ($000) $374 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 1,816 Value ($000) $309 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 1,478 Value ($000) $241 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 1,068 Value ($000) $160 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 1,019 Value ($000) $155 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 988 Value ($000) $127 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 856 Value ($000) $93 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 1,403 Value ($000) $103 Avg Close $81.37 Range $71.46 - $97.93

Q2 2016

Shares 1,351 Value ($000) $116 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,517 Value ($000) $120 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 1,160 Value ($000) $146 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 254 Value ($000) $26 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 302 Value ($000) $37 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 249 Value ($000) $29 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 215 Value ($000) $26 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 200 Value ($000) $22 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 200 Value ($000) $19 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 164 Value ($000) $12 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 635 Value ($000) $47 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 48 Value ($000) $4 Avg Close $79.58 Range $73.43 - $89.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,300	$3,763	$431.03	$392.50 - $464.44
Q3 2025	8,307	$3,253	$417.92	$362.50 - $484.56
Q2 2025	11,532	$5,134	$460.83	$416.60 - $510.77
Q1 2025	13,037	$6,321	$466.00	$397.25 - $519.68
Q4 2024	12,547	$5,053	$463.53	$377.85 - $519.88
Q3 2024	12,397	$5,766	$480.37	$456.07 - $510.64
Q2 2024	15,942	$7,471	$434.05	$391.01 - $486.43
Q1 2024	8,295	$3,467	$422.74	$403.43 - $448.40
Q4 2023	8,617	$3,506	$369.42	$341.85 - $413.00
Q3 2023	8,107	$2,819	$349.73	$335.82 - $367.00
Q2 2023	8,888	$3,128	$336.94	$313.47 - $354.94
Q1 2023	9,662	$3,044	$299.93	$282.21 - $325.19
Q4 2022	9,540	$2,755	$304.77	$283.58 - $324.75
Q3 2022	9,124	$2,642	$287.72	$271.61 - $305.95
Q2 2022	9,147	$2,578	$267.66	$233.01 - $293.17
Q1 2022	9,580	$2,501	$237.33	$214.66 - $263.58
Q4 2021	7,556	$1,660	$194.45	$176.36 - $224.49
Q3 2021	5,561	$1,008	$195.24	$180.02 - $204.88
Q2 2021	6,223	$1,255	$209.17	$185.33 - $222.78
Q1 2021	10,224	$2,197	$219.65	$204.62 - $242.99
Q4 2020	13,609	$3,217	$229.44	$202.57 - $280.99
Q3 2020	11,165	$3,038	$275.88	$253.97 - $306.08
Q2 2020	2,942	$855	$271.12	$222.39 - $299.21
Q1 2020	2,169	$516	$229.39	$197.47 - $249.85
Q4 2019	1,901	$416	$202.38	$165.23 - $225.66
Q3 2019	2,229	$378	$176.91	$165.27 - $188.44
Q2 2019	2,284	$419	$174.82	$163.68 - $191.71
Q1 2019	2,162	$398	$184.70	$160.95 - $195.81
Q4 2018	1,881	$312	$173.27	$151.80 - $194.92
Q3 2018	1,941	$374	$178.07	$164.70 - $193.78
Q2 2018	1,816	$309	$155.01	$144.07 - $172.00
Q1 2018	1,478	$241	$163.34	$146.21 - $178.15
Q4 2017	1,068	$160	$148.07	$136.50 - $158.04
Q3 2017	1,019	$155	$150.51	$125.50 - $167.86
Q2 2017	988	$127	$120.38	$107.24 - $137.26
Q1 2017	856	$93	$88.04	$73.34 - $111.88
Q4 2016	1,403	$103	$81.37	$71.46 - $97.93
Q2 2016	1,351	$116	$86.41	$75.92 - $96.49
Q1 2016	1,517	$120	$90.45	$75.90 - $124.96
Q4 2015	1,160	$146	$120.72	$101.49 - $134.71
Q3 2015	254	$26	$128.47	$97.45 - $143.45
Q2 2015	302	$37	$125.98	$113.68 - $137.50
Q1 2015	249	$29	$119.81	$103.75 - $136.33
Q4 2014	215	$26	$112.63	$96.43 - $124.35
Q3 2014	200	$22	$95.21	$84.41 - $116.88
Q2 2014	200	$19	$70.12	$59.79 - $98.80
Q1 2014	164	$12	$79.20	$67.49 - $87.77
Q4 2013	635	$47	$69.64	$58.06 - $78.38
Q3 2013	48	$4	$79.58	$73.43 - $89.96