VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CI INVESTMENTS INC.'s Holding History (CIK: 0001163648)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 49,891 Value ($000) $22,619 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 10,991 Value ($000) $4 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 13,128 Value ($000) $6 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 31,014 Value ($000) $15 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 35,868 Value ($000) $14 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 53,926 Value ($000) $25 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 13,428 Value ($000) $6 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 9,788 Value ($000) $4 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 6,763 Value ($000) $3 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 7,713 Value ($000) $3 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 8,225 Value ($000) $3 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 9,451 Value ($000) $3 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 7,714 Value ($000) $2 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 7,364 Value ($000) $2,132 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 5,663 Value ($000) $1,596 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 6,440 Value ($000) $1,681 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 5,889 Value ($000) $1,293 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 5,659 Value ($000) $1,026 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 4,167 Value ($000) $840 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 5,895 Value ($000) $1,267 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 4,198 Value ($000) $992 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 4,289 Value ($000) $1,167 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 4,516 Value ($000) $1,311 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 3,837 Value ($000) $913 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,117 Value ($000) $245 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 117 Value ($000) $20 Avg Close $176.91 Range $165.27 - $188.44

Q4 2018

Shares 700 Value ($000) $116 Avg Close $173.27 Range $151.80 - $194.92

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	49,891	$22,619	$431.03	$392.50 - $464.44
Q3 2025	10,991	$4	$417.92	$362.50 - $484.56
Q2 2025	13,128	$6	$460.83	$416.60 - $510.77
Q1 2025	31,014	$15	$466.00	$397.25 - $519.68
Q4 2024	35,868	$14	$463.53	$377.85 - $519.88
Q3 2024	53,926	$25	$480.37	$456.07 - $510.64
Q2 2024	13,428	$6	$434.05	$391.01 - $486.43
Q1 2024	9,788	$4	$422.74	$403.43 - $448.40
Q4 2023	6,763	$3	$369.42	$341.85 - $413.00
Q3 2023	7,713	$3	$349.73	$335.82 - $367.00
Q2 2023	8,225	$3	$336.94	$313.47 - $354.94
Q1 2023	9,451	$3	$299.93	$282.21 - $325.19
Q4 2022	7,714	$2	$304.77	$283.58 - $324.75
Q3 2022	7,364	$2,132	$287.72	$271.61 - $305.95
Q2 2022	5,663	$1,596	$267.66	$233.01 - $293.17
Q1 2022	6,440	$1,681	$237.33	$214.66 - $263.58
Q4 2021	5,889	$1,293	$194.45	$176.36 - $224.49
Q3 2021	5,659	$1,026	$195.24	$180.02 - $204.88
Q2 2021	4,167	$840	$209.17	$185.33 - $222.78
Q1 2021	5,895	$1,267	$219.65	$204.62 - $242.99
Q4 2020	4,198	$992	$229.44	$202.57 - $280.99
Q3 2020	4,289	$1,167	$275.88	$253.97 - $306.08
Q2 2020	4,516	$1,311	$271.12	$222.39 - $299.21
Q1 2020	3,837	$913	$229.39	$197.47 - $249.85
Q4 2019	1,117	$245	$202.38	$165.23 - $225.66
Q3 2019	117	$20	$176.91	$165.27 - $188.44
Q4 2018	700	$116	$173.27	$151.80 - $194.92