VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP's Holding History (CIK: 0001164508)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 593,947 Value ($000) $269,272 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 381,195 Value ($000) $149,291 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 61,470 Value ($000) $27,366 Avg Close $460.83 Range $416.60 - $510.77

Q4 2024

Shares 9,265 Value ($000) $3,731 Avg Close $463.53 Range $377.85 - $519.88

Q4 2022

Shares 5,233 Value ($000) $2 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 5,092 Value ($000) $1,474 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 9,790 Value ($000) $2,759 Avg Close $267.66 Range $233.01 - $293.17

Q4 2021

Shares 24,249 Value ($000) $5,325 Avg Close $194.45 Range $176.36 - $224.49

Q2 2021

Shares 324,105 Value ($000) $65,349 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 217,561 Value ($000) $46,752 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 390,799 Value ($000) $92,361 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 96,013 Value ($000) $26,127 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 82,582 Value ($000) $23,974 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 70,176 Value ($000) $16,698 Avg Close $229.39 Range $197.47 - $249.85

Q3 2019

Shares 3,436 Value ($000) $582 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 708,382 Value ($000) $129,903 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 841,509 Value ($000) $154,796 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 792,173 Value ($000) $131,271 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 801,867 Value ($000) $154,552 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 1,875,233 Value ($000) $318,715 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 2,125,216 Value ($000) $346,368 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 1,203,221 Value ($000) $180,315 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 632,934 Value ($000) $96,231 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 24,000 Value ($000) $3,093 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 72,800 Value ($000) $7,961 Avg Close $88.04 Range $73.34 - $111.88

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	593,947	$269,272	$431.03	$392.50 - $464.44
Q3 2025	381,195	$149,291	$417.92	$362.50 - $484.56
Q2 2025	61,470	$27,366	$460.83	$416.60 - $510.77
Q4 2024	9,265	$3,731	$463.53	$377.85 - $519.88
Q4 2022	5,233	$2	$304.77	$283.58 - $324.75
Q3 2022	5,092	$1,474	$287.72	$271.61 - $305.95
Q2 2022	9,790	$2,759	$267.66	$233.01 - $293.17
Q4 2021	24,249	$5,325	$194.45	$176.36 - $224.49
Q2 2021	324,105	$65,349	$209.17	$185.33 - $222.78
Q1 2021	217,561	$46,752	$219.65	$204.62 - $242.99
Q4 2020	390,799	$92,361	$229.44	$202.57 - $280.99
Q3 2020	96,013	$26,127	$275.88	$253.97 - $306.08
Q2 2020	82,582	$23,974	$271.12	$222.39 - $299.21
Q1 2020	70,176	$16,698	$229.39	$197.47 - $249.85
Q3 2019	3,436	$582	$176.91	$165.27 - $188.44
Q2 2019	708,382	$129,903	$174.82	$163.68 - $191.71
Q1 2019	841,509	$154,796	$184.70	$160.95 - $195.81
Q4 2018	792,173	$131,271	$173.27	$151.80 - $194.92
Q3 2018	801,867	$154,552	$178.07	$164.70 - $193.78
Q2 2018	1,875,233	$318,715	$155.01	$144.07 - $172.00
Q1 2018	2,125,216	$346,368	$163.34	$146.21 - $178.15
Q4 2017	1,203,221	$180,315	$148.07	$136.50 - $158.04
Q3 2017	632,934	$96,231	$150.51	$125.50 - $167.86
Q2 2017	24,000	$3,093	$120.38	$107.24 - $137.26
Q1 2017	72,800	$7,961	$88.04	$73.34 - $111.88