VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 272,474 Value ($000) $123,529 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 482,495 Value ($000) $188,964 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 178,192 Value ($000) $79,331 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 489,667 Value ($000) $237,400 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 209,239 Value ($000) $84,261 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 346,355 Value ($000) $161,083 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 335,161 Value ($000) $157,097 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 350,256 Value ($000) $146,411 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 300,190 Value ($000) $122,144 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 300,004 Value ($000) $104,323 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 306,033 Value ($000) $107,696 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 338,390 Value ($000) $106,617 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 179,890 Value ($000) $51,949 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 337,163 Value ($000) $97,622 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 572,030 Value ($000) $161,192 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 793,290 Value ($000) $207,025 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 220,890 Value ($000) $48,507 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 173,960 Value ($000) $31,555 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 338,940 Value ($000) $68,340 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 887,740 Value ($000) $190,766 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 682,140 Value ($000) $161,217 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 290,990 Value ($000) $79,184 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 399,652 Value ($000) $116,023 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 910,952 Value ($000) $216,761 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 809,701 Value ($000) $177,284 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 872,501 Value ($000) $147,819 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 653,141 Value ($000) $119,773 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 444,241 Value ($000) $81,718 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 432,512 Value ($000) $71,672 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 396,012 Value ($000) $76,327 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 860,904 Value ($000) $146,319 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 660,681 Value ($000) $107,678 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 1,359,281 Value ($000) $203,702 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 1,036,181 Value ($000) $157,541 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 964,981 Value ($000) $124,357 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 364,662 Value ($000) $39,876 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 254,127 Value ($000) $18,722 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 576,027 Value ($000) $50,235 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 695,827 Value ($000) $59,855 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 1,023,376 Value ($000) $81,348 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 1,413,776 Value ($000) $177,895 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 898,776 Value ($000) $93,599 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 909,776 Value ($000) $112,339 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 1,430,584 Value ($000) $168,766 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 2,095,132 Value ($000) $248,902 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 2,591,677 Value ($000) $291,071 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 2,967,367 Value ($000) $280,950 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 1,657,474 Value ($000) $117,217 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 3,807,061 Value ($000) $282,865 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 2,862,061 Value ($000) $217,001 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 3,071,274 Value ($000) $245,886 Avg Close $73.64 Range $51.28 - $87.47

Q1 2013

Shares 1,764,374 Value ($000) $96,988 Avg Close $48.01 Range $42.72 - $55.93

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	272,474	$123,529	$431.03	$392.50 - $464.44
Q3 2025	482,495	$188,964	$417.92	$362.50 - $484.56
Q2 2025	178,192	$79,331	$460.83	$416.60 - $510.77
Q1 2025	489,667	$237,400	$466.00	$397.25 - $519.68
Q4 2024	209,239	$84,261	$463.53	$377.85 - $519.88
Q3 2024	346,355	$161,083	$480.37	$456.07 - $510.64
Q2 2024	335,161	$157,097	$434.05	$391.01 - $486.43
Q1 2024	350,256	$146,411	$422.74	$403.43 - $448.40
Q4 2023	300,190	$122,144	$369.42	$341.85 - $413.00
Q3 2023	300,004	$104,323	$349.73	$335.82 - $367.00
Q2 2023	306,033	$107,696	$336.94	$313.47 - $354.94
Q1 2023	338,390	$106,617	$299.93	$282.21 - $325.19
Q4 2022	179,890	$51,949	$304.77	$283.58 - $324.75
Q3 2022	337,163	$97,622	$287.72	$271.61 - $305.95
Q2 2022	572,030	$161,192	$267.66	$233.01 - $293.17
Q1 2022	793,290	$207,025	$237.33	$214.66 - $263.58
Q4 2021	220,890	$48,507	$194.45	$176.36 - $224.49
Q3 2021	173,960	$31,555	$195.24	$180.02 - $204.88
Q2 2021	338,940	$68,340	$209.17	$185.33 - $222.78
Q1 2021	887,740	$190,766	$219.65	$204.62 - $242.99
Q4 2020	682,140	$161,217	$229.44	$202.57 - $280.99
Q3 2020	290,990	$79,184	$275.88	$253.97 - $306.08
Q2 2020	399,652	$116,023	$271.12	$222.39 - $299.21
Q1 2020	910,952	$216,761	$229.39	$197.47 - $249.85
Q4 2019	809,701	$177,284	$202.38	$165.23 - $225.66
Q3 2019	872,501	$147,819	$176.91	$165.27 - $188.44
Q2 2019	653,141	$119,773	$174.82	$163.68 - $191.71
Q1 2019	444,241	$81,718	$184.70	$160.95 - $195.81
Q4 2018	432,512	$71,672	$173.27	$151.80 - $194.92
Q3 2018	396,012	$76,327	$178.07	$164.70 - $193.78
Q2 2018	860,904	$146,319	$155.01	$144.07 - $172.00
Q1 2018	660,681	$107,678	$163.34	$146.21 - $178.15
Q4 2017	1,359,281	$203,702	$148.07	$136.50 - $158.04
Q3 2017	1,036,181	$157,541	$150.51	$125.50 - $167.86
Q2 2017	964,981	$124,357	$120.38	$107.24 - $137.26
Q1 2017	364,662	$39,876	$88.04	$73.34 - $111.88
Q4 2016	254,127	$18,722	$81.37	$71.46 - $97.93
Q3 2016	576,027	$50,235	$94.50	$83.50 - $103.73
Q2 2016	695,827	$59,855	$86.41	$75.92 - $96.49
Q1 2016	1,023,376	$81,348	$90.45	$75.90 - $124.96
Q4 2015	1,413,776	$177,895	$120.72	$101.49 - $134.71
Q3 2015	898,776	$93,599	$128.47	$97.45 - $143.45
Q2 2015	909,776	$112,339	$125.98	$113.68 - $137.50
Q1 2015	1,430,584	$168,766	$119.81	$103.75 - $136.33
Q4 2014	2,095,132	$248,902	$112.63	$96.43 - $124.35
Q3 2014	2,591,677	$291,071	$95.21	$84.41 - $116.88
Q2 2014	2,967,367	$280,950	$70.12	$59.79 - $98.80
Q1 2014	1,657,474	$117,217	$79.20	$67.49 - $87.77
Q4 2013	3,807,061	$282,865	$69.64	$58.06 - $78.38
Q3 2013	2,862,061	$217,001	$79.58	$73.43 - $89.96
Q2 2013	3,071,274	$245,886	$73.64	$51.28 - $87.47
Q1 2013	1,764,374	$96,988	$48.01	$42.72 - $55.93