VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

LOS ANGELES CAPITAL MANAGEMENT LLC's Holding History (CIK: 0001177206)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 293,301 Value ($000) $123,154 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 35,472 Value ($000) $13,892 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 33,014 Value ($000) $14,698 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 25,723 Value ($000) $12,471 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 1,302 Value ($000) $524 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 18,727 Value ($000) $8,710 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 64,696 Value ($000) $30,324 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 132,714 Value ($000) $55,476 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 389,874 Value ($000) $158,636 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 427,070 Value ($000) $148,509 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 426,228 Value ($000) $149,994 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 457,155 Value ($000) $144,036 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 447,011 Value ($000) $129,088 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 434,526 Value ($000) $125,813 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 337,466 Value ($000) $95,095 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 354,818 Value ($000) $92,597 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 302,005 Value ($000) $66,320 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 154,129 Value ($000) $27,957 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 169,357 Value ($000) $34,147 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 224,420 Value ($000) $48,226 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 307,064 Value ($000) $72,572 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 316,315 Value ($000) $86,076 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 332,912 Value ($000) $96,648 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 310,500 Value ($000) $73,883 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 306,110 Value ($000) $67,023 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 383,563 Value ($000) $64,983 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 433,986 Value ($000) $79,584 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 434,986 Value ($000) $80,016 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 441,986 Value ($000) $73,242 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 540,817 Value ($000) $104,237 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 539,158 Value ($000) $91,635 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 316,840 Value ($000) $51,639 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 319,520 Value ($000) $47,883 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 85,339 Value ($000) $12,975 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 3,612 Value ($000) $465 Avg Close $120.38 Range $107.24 - $137.26

Q4 2016

Shares 23,268 Value ($000) $1,714 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 177,280 Value ($000) $15,461 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 189,101 Value ($000) $16,266 Avg Close $86.41 Range $75.92 - $96.49

Q4 2015

Shares 2,114 Value ($000) $266 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 4,436 Value ($000) $462 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 329,565 Value ($000) $40,695 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 312,315 Value ($000) $36,844 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 2,514 Value ($000) $299 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 2,514 Value ($000) $282 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 2,514 Value ($000) $238 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 82,744 Value ($000) $5,852 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 113,854 Value ($000) $8,459 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 168,106 Value ($000) $12,746 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 10,713 Value ($000) $858 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	293,301	$123,154	$431.03	$392.50 - $464.44
Q3 2025	35,472	$13,892	$417.92	$362.50 - $484.56
Q2 2025	33,014	$14,698	$460.83	$416.60 - $510.77
Q1 2025	25,723	$12,471	$466.00	$397.25 - $519.68
Q4 2024	1,302	$524	$463.53	$377.85 - $519.88
Q3 2024	18,727	$8,710	$480.37	$456.07 - $510.64
Q2 2024	64,696	$30,324	$434.05	$391.01 - $486.43
Q1 2024	132,714	$55,476	$422.74	$403.43 - $448.40
Q4 2023	389,874	$158,636	$369.42	$341.85 - $413.00
Q3 2023	427,070	$148,509	$349.73	$335.82 - $367.00
Q2 2023	426,228	$149,994	$336.94	$313.47 - $354.94
Q1 2023	457,155	$144,036	$299.93	$282.21 - $325.19
Q4 2022	447,011	$129,088	$304.77	$283.58 - $324.75
Q3 2022	434,526	$125,813	$287.72	$271.61 - $305.95
Q2 2022	337,466	$95,095	$267.66	$233.01 - $293.17
Q1 2022	354,818	$92,597	$237.33	$214.66 - $263.58
Q4 2021	302,005	$66,320	$194.45	$176.36 - $224.49
Q3 2021	154,129	$27,957	$195.24	$180.02 - $204.88
Q2 2021	169,357	$34,147	$209.17	$185.33 - $222.78
Q1 2021	224,420	$48,226	$219.65	$204.62 - $242.99
Q4 2020	307,064	$72,572	$229.44	$202.57 - $280.99
Q3 2020	316,315	$86,076	$275.88	$253.97 - $306.08
Q2 2020	332,912	$96,648	$271.12	$222.39 - $299.21
Q1 2020	310,500	$73,883	$229.39	$197.47 - $249.85
Q4 2019	306,110	$67,023	$202.38	$165.23 - $225.66
Q3 2019	383,563	$64,983	$176.91	$165.27 - $188.44
Q2 2019	433,986	$79,584	$174.82	$163.68 - $191.71
Q1 2019	434,986	$80,016	$184.70	$160.95 - $195.81
Q4 2018	441,986	$73,242	$173.27	$151.80 - $194.92
Q3 2018	540,817	$104,237	$178.07	$164.70 - $193.78
Q2 2018	539,158	$91,635	$155.01	$144.07 - $172.00
Q1 2018	316,840	$51,639	$163.34	$146.21 - $178.15
Q4 2017	319,520	$47,883	$148.07	$136.50 - $158.04
Q3 2017	85,339	$12,975	$150.51	$125.50 - $167.86
Q2 2017	3,612	$465	$120.38	$107.24 - $137.26
Q4 2016	23,268	$1,714	$81.37	$71.46 - $97.93
Q3 2016	177,280	$15,461	$94.50	$83.50 - $103.73
Q2 2016	189,101	$16,266	$86.41	$75.92 - $96.49
Q4 2015	2,114	$266	$120.72	$101.49 - $134.71
Q3 2015	4,436	$462	$128.47	$97.45 - $143.45
Q2 2015	329,565	$40,695	$125.98	$113.68 - $137.50
Q1 2015	312,315	$36,844	$119.81	$103.75 - $136.33
Q4 2014	2,514	$299	$112.63	$96.43 - $124.35
Q3 2014	2,514	$282	$95.21	$84.41 - $116.88
Q2 2014	2,514	$238	$70.12	$59.79 - $98.80
Q1 2014	82,744	$5,852	$79.20	$67.49 - $87.77
Q4 2013	113,854	$8,459	$69.64	$58.06 - $78.38
Q3 2013	168,106	$12,746	$79.58	$73.43 - $89.96
Q2 2013	10,713	$858	$73.64	$51.28 - $87.47