VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,155 Value ($000) $1,884 Avg Close $431.03 Range $392.50 - $464.44

Q1 2025

Shares 4,121 Value ($000) $1,998 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 33,160 Value ($000) $13,354 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 160,535 Value ($000) $74,662 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 331,987 Value ($000) $155,609 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 324,428 Value ($000) $135,614 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 136,174 Value ($000) $55,408 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 259,429 Value ($000) $90,214 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 388,883 Value ($000) $136,852 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 91,255 Value ($000) $28,752 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 29,122 Value ($000) $8,410 Avg Close $304.77 Range $283.58 - $324.75

Q1 2022

Shares 33,644 Value ($000) $8,780 Avg Close $237.33 Range $214.66 - $263.58

Q3 2021

Shares 959,684 Value ($000) $174,077 Avg Close $195.24 Range $180.02 - $204.88

Q2 2020

Shares 102,102 Value ($000) $29,641 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 465,146 Value ($000) $110,681 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 793,469 Value ($000) $173,730 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 512,635 Value ($000) $86,851 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 417,171 Value ($000) $76,501 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 660,524 Value ($000) $121,503 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 407,069 Value ($000) $67,455 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 578,583 Value ($000) $111,516 Avg Close $178.07 Range $164.70 - $193.78

Q1 2018

Shares 44,054 Value ($000) $7,180 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 912,724 Value ($000) $136,781 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 450,308 Value ($000) $68,465 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 390,070 Value ($000) $50,268 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 645,430 Value ($000) $70,578 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 1,026,855 Value ($000) $75,648 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 422,349 Value ($000) $36,833 Avg Close $94.50 Range $83.50 - $103.73

Q1 2016

Shares 995,248 Value ($000) $79,112 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 342,901 Value ($000) $43,147 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 430,551 Value ($000) $44,838 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 156,298 Value ($000) $19,300 Avg Close $125.98 Range $113.68 - $137.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,155	$1,884	$431.03	$392.50 - $464.44
Q1 2025	4,121	$1,998	$466.00	$397.25 - $519.68
Q4 2024	33,160	$13,354	$463.53	$377.85 - $519.88
Q3 2024	160,535	$74,662	$480.37	$456.07 - $510.64
Q2 2024	331,987	$155,609	$434.05	$391.01 - $486.43
Q1 2024	324,428	$135,614	$422.74	$403.43 - $448.40
Q4 2023	136,174	$55,408	$369.42	$341.85 - $413.00
Q3 2023	259,429	$90,214	$349.73	$335.82 - $367.00
Q2 2023	388,883	$136,852	$336.94	$313.47 - $354.94
Q1 2023	91,255	$28,752	$299.93	$282.21 - $325.19
Q4 2022	29,122	$8,410	$304.77	$283.58 - $324.75
Q1 2022	33,644	$8,780	$237.33	$214.66 - $263.58
Q3 2021	959,684	$174,077	$195.24	$180.02 - $204.88
Q2 2020	102,102	$29,641	$271.12	$222.39 - $299.21
Q1 2020	465,146	$110,681	$229.39	$197.47 - $249.85
Q4 2019	793,469	$173,730	$202.38	$165.23 - $225.66
Q3 2019	512,635	$86,851	$176.91	$165.27 - $188.44
Q2 2019	417,171	$76,501	$174.82	$163.68 - $191.71
Q1 2019	660,524	$121,503	$184.70	$160.95 - $195.81
Q4 2018	407,069	$67,455	$173.27	$151.80 - $194.92
Q3 2018	578,583	$111,516	$178.07	$164.70 - $193.78
Q1 2018	44,054	$7,180	$163.34	$146.21 - $178.15
Q4 2017	912,724	$136,781	$148.07	$136.50 - $158.04
Q3 2017	450,308	$68,465	$150.51	$125.50 - $167.86
Q2 2017	390,070	$50,268	$120.38	$107.24 - $137.26
Q1 2017	645,430	$70,578	$88.04	$73.34 - $111.88
Q4 2016	1,026,855	$75,648	$81.37	$71.46 - $97.93
Q3 2016	422,349	$36,833	$94.50	$83.50 - $103.73
Q1 2016	995,248	$79,112	$90.45	$75.90 - $124.96
Q4 2015	342,901	$43,147	$120.72	$101.49 - $134.71
Q3 2015	430,551	$44,838	$128.47	$97.45 - $143.45
Q2 2015	156,298	$19,300	$125.98	$113.68 - $137.50