VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

MILLENNIUM MANAGEMENT LLC's Holding History (CIK: 0001273087)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 365,664 Value ($000) $165,777 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 41,042 Value ($000) $16,074 Avg Close $417.92 Range $362.50 - $484.56

Q1 2025

Shares 309,935 Value ($000) $150,263 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 310,643 Value ($000) $125,096 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 159,294 Value ($000) $74,084 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 142,759 Value ($000) $66,914 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 324,816 Value ($000) $135,776 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 642,750 Value ($000) $261,529 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 545,329 Value ($000) $189,633 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 1,066,718 Value ($000) $375,389 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 7,036 Value ($000) $2 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 336,562 Value ($000) $97 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 3,538 Value ($000) $1,024 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 291,503 Value ($000) $82,143 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 313,136 Value ($000) $81,719 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 446,853 Value ($000) $98,129 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 695,708 Value ($000) $126,194 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 364,412 Value ($000) $73,476 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 905,921 Value ($000) $194,673 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 313,747 Value ($000) $74,151 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 44,349 Value ($000) $12,068 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 150,941 Value ($000) $43,820 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 93,248 Value ($000) $22,188 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 397,804 Value ($000) $87,099 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 401,489 Value ($000) $68,020 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 500,603 Value ($000) $91,801 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 610,211 Value ($000) $112,248 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,230,851 Value ($000) $203,964 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,008,327 Value ($000) $194,345 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 663,597 Value ($000) $112,785 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 568,549 Value ($000) $92,662 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 1,228,083 Value ($000) $184,041 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 1,668,208 Value ($000) $253,634 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 777,466 Value ($000) $100,192 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 1,007,060 Value ($000) $110,122 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 545,600 Value ($000) $40,194 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 298,736 Value ($000) $26,053 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 2,603 Value ($000) $224 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 679,656 Value ($000) $54,026 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 1,400,137 Value ($000) $176,179 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 1,579,374 Value ($000) $164,476 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 411,636 Value ($000) $50,829 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 89,029 Value ($000) $10,503 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 755,124 Value ($000) $89,709 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 472,950 Value ($000) $53,117 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 491,222 Value ($000) $46,509 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 233,814 Value ($000) $16,535 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 110,051 Value ($000) $8,177 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 321,254 Value ($000) $24,357 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 259,941 Value ($000) $20,811 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	365,664	$165,777	$431.03	$392.50 - $464.44
Q3 2025	41,042	$16,074	$417.92	$362.50 - $484.56
Q1 2025	309,935	$150,263	$466.00	$397.25 - $519.68
Q4 2024	310,643	$125,096	$463.53	$377.85 - $519.88
Q3 2024	159,294	$74,084	$480.37	$456.07 - $510.64
Q2 2024	142,759	$66,914	$434.05	$391.01 - $486.43
Q1 2024	324,816	$135,776	$422.74	$403.43 - $448.40
Q4 2023	642,750	$261,529	$369.42	$341.85 - $413.00
Q3 2023	545,329	$189,633	$349.73	$335.82 - $367.00
Q2 2023	1,066,718	$375,389	$336.94	$313.47 - $354.94
Q1 2023	7,036	$2	$299.93	$282.21 - $325.19
Q4 2022	336,562	$97	$304.77	$283.58 - $324.75
Q3 2022	3,538	$1,024	$287.72	$271.61 - $305.95
Q2 2022	291,503	$82,143	$267.66	$233.01 - $293.17
Q1 2022	313,136	$81,719	$237.33	$214.66 - $263.58
Q4 2021	446,853	$98,129	$194.45	$176.36 - $224.49
Q3 2021	695,708	$126,194	$195.24	$180.02 - $204.88
Q2 2021	364,412	$73,476	$209.17	$185.33 - $222.78
Q1 2021	905,921	$194,673	$219.65	$204.62 - $242.99
Q4 2020	313,747	$74,151	$229.44	$202.57 - $280.99
Q3 2020	44,349	$12,068	$275.88	$253.97 - $306.08
Q2 2020	150,941	$43,820	$271.12	$222.39 - $299.21
Q1 2020	93,248	$22,188	$229.39	$197.47 - $249.85
Q4 2019	397,804	$87,099	$202.38	$165.23 - $225.66
Q3 2019	401,489	$68,020	$176.91	$165.27 - $188.44
Q2 2019	500,603	$91,801	$174.82	$163.68 - $191.71
Q1 2019	610,211	$112,248	$184.70	$160.95 - $195.81
Q4 2018	1,230,851	$203,964	$173.27	$151.80 - $194.92
Q3 2018	1,008,327	$194,345	$178.07	$164.70 - $193.78
Q2 2018	663,597	$112,785	$155.01	$144.07 - $172.00
Q1 2018	568,549	$92,662	$163.34	$146.21 - $178.15
Q4 2017	1,228,083	$184,041	$148.07	$136.50 - $158.04
Q3 2017	1,668,208	$253,634	$150.51	$125.50 - $167.86
Q2 2017	777,466	$100,192	$120.38	$107.24 - $137.26
Q1 2017	1,007,060	$110,122	$88.04	$73.34 - $111.88
Q4 2016	545,600	$40,194	$81.37	$71.46 - $97.93
Q3 2016	298,736	$26,053	$94.50	$83.50 - $103.73
Q2 2016	2,603	$224	$86.41	$75.92 - $96.49
Q1 2016	679,656	$54,026	$90.45	$75.90 - $124.96
Q4 2015	1,400,137	$176,179	$120.72	$101.49 - $134.71
Q3 2015	1,579,374	$164,476	$128.47	$97.45 - $143.45
Q2 2015	411,636	$50,829	$125.98	$113.68 - $137.50
Q1 2015	89,029	$10,503	$119.81	$103.75 - $136.33
Q4 2014	755,124	$89,709	$112.63	$96.43 - $124.35
Q3 2014	472,950	$53,117	$95.21	$84.41 - $116.88
Q2 2014	491,222	$46,509	$70.12	$59.79 - $98.80
Q1 2014	233,814	$16,535	$79.20	$67.49 - $87.77
Q4 2013	110,051	$8,177	$69.64	$58.06 - $78.38
Q3 2013	321,254	$24,357	$79.58	$73.43 - $89.96
Q2 2013	259,941	$20,811	$73.64	$51.28 - $87.47