VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

SECTORAL ASSET MANAGEMENT INC's Holding History (CIK: 0001274413)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,005 Value ($000) $3,629 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 7,715 Value ($000) $3,022 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 6,945 Value ($000) $3,092 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 4,725 Value ($000) $2,291 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 3,670 Value ($000) $1,478 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 4,840 Value ($000) $2,251 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 8,650 Value ($000) $4,054 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 7,210 Value ($000) $3,014 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 9,219 Value ($000) $3,751 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 8,769 Value ($000) $3,049 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 8,164 Value ($000) $2,873 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 6,619 Value ($000) $2,085 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 7,019 Value ($000) $2,027 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 7,918 Value ($000) $2,293 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 8,118 Value ($000) $2,288 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 7,281 Value ($000) $1,900 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 7,771 Value ($000) $1,707 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 9,721 Value ($000) $1,763 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 9,721 Value ($000) $1,960 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 11,321 Value ($000) $2,433 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 16,921 Value ($000) $3,999 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 9,871 Value ($000) $2,686 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 14,671 Value ($000) $4,259 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 16,171 Value ($000) $3,848 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 16,071 Value ($000) $3,519 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 14,171 Value ($000) $2,401 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 37,771 Value ($000) $6,926 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 20,271 Value ($000) $3,729 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 36,217 Value ($000) $6,002 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 76,846 Value ($000) $14,811 Avg Close $178.07 Range $164.70 - $193.78

Q1 2018

Shares 41,915 Value ($000) $6,831 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 36,715 Value ($000) $5,502 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 34,000 Value ($000) $5,169 Avg Close $150.51 Range $125.50 - $167.86

Q3 2016

Shares 217,874 Value ($000) $19,001 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 231,575 Value ($000) $19,920 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 896,479 Value ($000) $71,261 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 688,200 Value ($000) $86,596 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 734,200 Value ($000) $76,460 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 598,800 Value ($000) $73,940 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 509,600 Value ($000) $60,118 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 212,250 Value ($000) $25,215 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 329,897 Value ($000) $37,051 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 1,079,464 Value ($000) $102,204 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 1,276,741 Value ($000) $90,291 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 1,232,158 Value ($000) $91,549 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 1,235,755 Value ($000) $93,695 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 2,526,014 Value ($000) $202,233 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,005	$3,629	$431.03	$392.50 - $464.44
Q3 2025	7,715	$3,022	$417.92	$362.50 - $484.56
Q2 2025	6,945	$3,092	$460.83	$416.60 - $510.77
Q1 2025	4,725	$2,291	$466.00	$397.25 - $519.68
Q4 2024	3,670	$1,478	$463.53	$377.85 - $519.88
Q3 2024	4,840	$2,251	$480.37	$456.07 - $510.64
Q2 2024	8,650	$4,054	$434.05	$391.01 - $486.43
Q1 2024	7,210	$3,014	$422.74	$403.43 - $448.40
Q4 2023	9,219	$3,751	$369.42	$341.85 - $413.00
Q3 2023	8,769	$3,049	$349.73	$335.82 - $367.00
Q2 2023	8,164	$2,873	$336.94	$313.47 - $354.94
Q1 2023	6,619	$2,085	$299.93	$282.21 - $325.19
Q4 2022	7,019	$2,027	$304.77	$283.58 - $324.75
Q3 2022	7,918	$2,293	$287.72	$271.61 - $305.95
Q2 2022	8,118	$2,288	$267.66	$233.01 - $293.17
Q1 2022	7,281	$1,900	$237.33	$214.66 - $263.58
Q4 2021	7,771	$1,707	$194.45	$176.36 - $224.49
Q3 2021	9,721	$1,763	$195.24	$180.02 - $204.88
Q2 2021	9,721	$1,960	$209.17	$185.33 - $222.78
Q1 2021	11,321	$2,433	$219.65	$204.62 - $242.99
Q4 2020	16,921	$3,999	$229.44	$202.57 - $280.99
Q3 2020	9,871	$2,686	$275.88	$253.97 - $306.08
Q2 2020	14,671	$4,259	$271.12	$222.39 - $299.21
Q1 2020	16,171	$3,848	$229.39	$197.47 - $249.85
Q4 2019	16,071	$3,519	$202.38	$165.23 - $225.66
Q3 2019	14,171	$2,401	$176.91	$165.27 - $188.44
Q2 2019	37,771	$6,926	$174.82	$163.68 - $191.71
Q1 2019	20,271	$3,729	$184.70	$160.95 - $195.81
Q4 2018	36,217	$6,002	$173.27	$151.80 - $194.92
Q3 2018	76,846	$14,811	$178.07	$164.70 - $193.78
Q1 2018	41,915	$6,831	$163.34	$146.21 - $178.15
Q4 2017	36,715	$5,502	$148.07	$136.50 - $158.04
Q3 2017	34,000	$5,169	$150.51	$125.50 - $167.86
Q3 2016	217,874	$19,001	$94.50	$83.50 - $103.73
Q2 2016	231,575	$19,920	$86.41	$75.92 - $96.49
Q1 2016	896,479	$71,261	$90.45	$75.90 - $124.96
Q4 2015	688,200	$86,596	$120.72	$101.49 - $134.71
Q3 2015	734,200	$76,460	$128.47	$97.45 - $143.45
Q2 2015	598,800	$73,940	$125.98	$113.68 - $137.50
Q1 2015	509,600	$60,118	$119.81	$103.75 - $136.33
Q4 2014	212,250	$25,215	$112.63	$96.43 - $124.35
Q3 2014	329,897	$37,051	$95.21	$84.41 - $116.88
Q2 2014	1,079,464	$102,204	$70.12	$59.79 - $98.80
Q1 2014	1,276,741	$90,291	$79.20	$67.49 - $87.77
Q4 2013	1,232,158	$91,549	$69.64	$58.06 - $78.38
Q3 2013	1,235,755	$93,695	$79.58	$73.43 - $89.96
Q2 2013	2,526,014	$202,233	$73.64	$51.28 - $87.47