VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

NATIXIS's Holding History (CIK: 0001274981)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 60,218 Value ($000) $27,300 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 29,806 Value ($000) $11,673 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 30,961 Value ($000) $13,784 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 55,434 Value ($000) $26,792 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 22,862 Value ($000) $9,207 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 36,727 Value ($000) $17,081 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 44,332 Value ($000) $20,779 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 44,638 Value ($000) $18,659 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 51,906 Value ($000) $21,120 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 181,172 Value ($000) $63,001 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 91,487 Value ($000) $32,195 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 17,500 Value ($000) $5,514 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 78,478 Value ($000) $22,663 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 23,285 Value ($000) $6,742 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 32,517 Value ($000) $9,163 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 5,296 Value ($000) $1,382 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 20,423 Value ($000) $4,485 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 187,075 Value ($000) $33,934 Avg Close $195.24 Range $180.02 - $204.88

Q1 2021

Shares 60,011 Value ($000) $12,896 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 57,778 Value ($000) $13,655 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 20,256 Value ($000) $5,512 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 23,059 Value ($000) $6,694 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 9,543 Value ($000) $2,271 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 66,615 Value ($000) $14,587 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 186,069 Value ($000) $31,524 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 156,553 Value ($000) $28,709 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 48,606 Value ($000) $8,867 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 358,912 Value ($000) $59,475 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 161,993 Value ($000) $31,223 Avg Close $178.07 Range $164.70 - $193.78

Q4 2017

Shares 487,993 Value ($000) $73,131 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 20,280 Value ($000) $3,083 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 5,733 Value ($000) $739 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 11,241 Value ($000) $1,229 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 333,412 Value ($000) $24,562 Avg Close $81.37 Range $71.46 - $97.93

Q2 2015

Shares 7,442 Value ($000) $919 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 101,404 Value ($000) $11,963 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 129,053 Value ($000) $15,331 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 132,103 Value ($000) $14,836 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 17,168 Value ($000) $1,625 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 39,050 Value ($000) $2,762 Avg Close $79.20 Range $67.49 - $87.77

Q2 2013

Shares 10,000 Value ($000) $799 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	60,218	$27,300	$431.03	$392.50 - $464.44
Q3 2025	29,806	$11,673	$417.92	$362.50 - $484.56
Q2 2025	30,961	$13,784	$460.83	$416.60 - $510.77
Q1 2025	55,434	$26,792	$466.00	$397.25 - $519.68
Q4 2024	22,862	$9,207	$463.53	$377.85 - $519.88
Q3 2024	36,727	$17,081	$480.37	$456.07 - $510.64
Q2 2024	44,332	$20,779	$434.05	$391.01 - $486.43
Q1 2024	44,638	$18,659	$422.74	$403.43 - $448.40
Q4 2023	51,906	$21,120	$369.42	$341.85 - $413.00
Q3 2023	181,172	$63,001	$349.73	$335.82 - $367.00
Q2 2023	91,487	$32,195	$336.94	$313.47 - $354.94
Q1 2023	17,500	$5,514	$299.93	$282.21 - $325.19
Q4 2022	78,478	$22,663	$304.77	$283.58 - $324.75
Q3 2022	23,285	$6,742	$287.72	$271.61 - $305.95
Q2 2022	32,517	$9,163	$267.66	$233.01 - $293.17
Q1 2022	5,296	$1,382	$237.33	$214.66 - $263.58
Q4 2021	20,423	$4,485	$194.45	$176.36 - $224.49
Q3 2021	187,075	$33,934	$195.24	$180.02 - $204.88
Q1 2021	60,011	$12,896	$219.65	$204.62 - $242.99
Q4 2020	57,778	$13,655	$229.44	$202.57 - $280.99
Q3 2020	20,256	$5,512	$275.88	$253.97 - $306.08
Q2 2020	23,059	$6,694	$271.12	$222.39 - $299.21
Q1 2020	9,543	$2,271	$229.39	$197.47 - $249.85
Q4 2019	66,615	$14,587	$202.38	$165.23 - $225.66
Q3 2019	186,069	$31,524	$176.91	$165.27 - $188.44
Q2 2019	156,553	$28,709	$174.82	$163.68 - $191.71
Q1 2019	48,606	$8,867	$184.70	$160.95 - $195.81
Q4 2018	358,912	$59,475	$173.27	$151.80 - $194.92
Q3 2018	161,993	$31,223	$178.07	$164.70 - $193.78
Q4 2017	487,993	$73,131	$148.07	$136.50 - $158.04
Q3 2017	20,280	$3,083	$150.51	$125.50 - $167.86
Q2 2017	5,733	$739	$120.38	$107.24 - $137.26
Q1 2017	11,241	$1,229	$88.04	$73.34 - $111.88
Q4 2016	333,412	$24,562	$81.37	$71.46 - $97.93
Q2 2015	7,442	$919	$125.98	$113.68 - $137.50
Q1 2015	101,404	$11,963	$119.81	$103.75 - $136.33
Q4 2014	129,053	$15,331	$112.63	$96.43 - $124.35
Q3 2014	132,103	$14,836	$95.21	$84.41 - $116.88
Q2 2014	17,168	$1,625	$70.12	$59.79 - $98.80
Q1 2014	39,050	$2,762	$79.20	$67.49 - $87.77
Q2 2013	10,000	$799	$73.64	$51.28 - $87.47