VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Destination Wealth Management's Holding History (CIK: 0001278573)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,538 Value ($000) $697 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 1,642 Value ($000) $643 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 1,553 Value ($000) $691 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 3,277 Value ($000) $1,589 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 3,529 Value ($000) $1,421 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 3,361 Value ($000) $1,563 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 3,217 Value ($000) $1,508 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 3,200 Value ($000) $1,338 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 3,197 Value ($000) $1,301 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 3,090 Value ($000) $1,075 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 3,092 Value ($000) $1,088 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 3,092 Value ($000) $974 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 3,192 Value ($000) $922 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 3,092 Value ($000) $895 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 3,092 Value ($000) $871 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 3,098 Value ($000) $808 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 3,087 Value ($000) $678 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 3,087 Value ($000) $560 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 3,131 Value ($000) $631 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 3,128 Value ($000) $672 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 3,121 Value ($000) $738 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 3,098 Value ($000) $843 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 3,098 Value ($000) $899 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 3,445 Value ($000) $820 Avg Close $229.39 Range $197.47 - $249.85

Q1 2019

Shares 17 Value ($000) $3 Avg Close $184.70 Range $160.95 - $195.81

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,538	$697	$431.03	$392.50 - $464.44
Q3 2025	1,642	$643	$417.92	$362.50 - $484.56
Q2 2025	1,553	$691	$460.83	$416.60 - $510.77
Q1 2025	3,277	$1,589	$466.00	$397.25 - $519.68
Q4 2024	3,529	$1,421	$463.53	$377.85 - $519.88
Q3 2024	3,361	$1,563	$480.37	$456.07 - $510.64
Q2 2024	3,217	$1,508	$434.05	$391.01 - $486.43
Q1 2024	3,200	$1,338	$422.74	$403.43 - $448.40
Q4 2023	3,197	$1,301	$369.42	$341.85 - $413.00
Q3 2023	3,090	$1,075	$349.73	$335.82 - $367.00
Q2 2023	3,092	$1,088	$336.94	$313.47 - $354.94
Q1 2023	3,092	$974	$299.93	$282.21 - $325.19
Q4 2022	3,192	$922	$304.77	$283.58 - $324.75
Q3 2022	3,092	$895	$287.72	$271.61 - $305.95
Q2 2022	3,092	$871	$267.66	$233.01 - $293.17
Q1 2022	3,098	$808	$237.33	$214.66 - $263.58
Q4 2021	3,087	$678	$194.45	$176.36 - $224.49
Q3 2021	3,087	$560	$195.24	$180.02 - $204.88
Q2 2021	3,131	$631	$209.17	$185.33 - $222.78
Q1 2021	3,128	$672	$219.65	$204.62 - $242.99
Q4 2020	3,121	$738	$229.44	$202.57 - $280.99
Q3 2020	3,098	$843	$275.88	$253.97 - $306.08
Q2 2020	3,098	$899	$271.12	$222.39 - $299.21
Q1 2020	3,445	$820	$229.39	$197.47 - $249.85
Q1 2019	17	$3	$184.70	$160.95 - $195.81