VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CANADA PENSION PLAN INVESTMENT BOARD's Holding History (CIK: 0001283718)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 202,333 Value ($000) $91,730 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 246,364 Value ($000) $96,486 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 167,408 Value ($000) $74,530 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 154,429 Value ($000) $74,870 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 369,354 Value ($000) $148,739 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 284,004 Value ($000) $132,085 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 337,116 Value ($000) $158,013 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 386,648 Value ($000) $161,623 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 357,901 Value ($000) $145,626 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 348,824 Value ($000) $121,300 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 288,901 Value ($000) $101,667 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 312,926 Value ($000) $98,594 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 279,401 Value ($000) $80,685 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 1,605,854 Value ($000) $464,959 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 1,648,974 Value ($000) $464,664 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 1,640,031 Value ($000) $427,999 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 1,708,354 Value ($000) $375,155 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,692,794 Value ($000) $307,056 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 1,782,751 Value ($000) $359,456 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,227,475 Value ($000) $263,772 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 53,298 Value ($000) $12,596 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 69,263 Value ($000) $18,848 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 73,263 Value ($000) $21,269 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 48,136 Value ($000) $11,454 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 106,205 Value ($000) $23,254 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 365,820 Value ($000) $61,977 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 369,880 Value ($000) $67,829 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 455,581 Value ($000) $83,804 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 432,373 Value ($000) $71,643 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 344,373 Value ($000) $66,374 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 341,943 Value ($000) $58,117 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 319,055 Value ($000) $52,000 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 345,555 Value ($000) $51,785 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 189,655 Value ($000) $28,835 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 107,455 Value ($000) $13,848 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 247,523 Value ($000) $27,067 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 85,923 Value ($000) $6,330 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 61,584 Value ($000) $5,371 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 130,733 Value ($000) $11,246 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 201,733 Value ($000) $16,036 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 106,433 Value ($000) $13,392 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 76,210 Value ($000) $7,937 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 73,433 Value ($000) $9,068 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 26,933 Value ($000) $3,177 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 26,933 Value ($000) $3,200 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 26,933 Value ($000) $3,025 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 14,432 Value ($000) $1,366 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 74,214 Value ($000) $5,248 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 101,840 Value ($000) $7,567 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 47,923 Value ($000) $3,634 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 58,684 Value ($000) $4,698 Avg Close $73.64 Range $51.28 - $87.47

Q1 2013

Shares 53,484 Value ($000) $2,940 Avg Close $48.01 Range $42.72 - $55.93

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	202,333	$91,730	$431.03	$392.50 - $464.44
Q3 2025	246,364	$96,486	$417.92	$362.50 - $484.56
Q2 2025	167,408	$74,530	$460.83	$416.60 - $510.77
Q1 2025	154,429	$74,870	$466.00	$397.25 - $519.68
Q4 2024	369,354	$148,739	$463.53	$377.85 - $519.88
Q3 2024	284,004	$132,085	$480.37	$456.07 - $510.64
Q2 2024	337,116	$158,013	$434.05	$391.01 - $486.43
Q1 2024	386,648	$161,623	$422.74	$403.43 - $448.40
Q4 2023	357,901	$145,626	$369.42	$341.85 - $413.00
Q3 2023	348,824	$121,300	$349.73	$335.82 - $367.00
Q2 2023	288,901	$101,667	$336.94	$313.47 - $354.94
Q1 2023	312,926	$98,594	$299.93	$282.21 - $325.19
Q4 2022	279,401	$80,685	$304.77	$283.58 - $324.75
Q3 2022	1,605,854	$464,959	$287.72	$271.61 - $305.95
Q2 2022	1,648,974	$464,664	$267.66	$233.01 - $293.17
Q1 2022	1,640,031	$427,999	$237.33	$214.66 - $263.58
Q4 2021	1,708,354	$375,155	$194.45	$176.36 - $224.49
Q3 2021	1,692,794	$307,056	$195.24	$180.02 - $204.88
Q2 2021	1,782,751	$359,456	$209.17	$185.33 - $222.78
Q1 2021	1,227,475	$263,772	$219.65	$204.62 - $242.99
Q4 2020	53,298	$12,596	$229.44	$202.57 - $280.99
Q3 2020	69,263	$18,848	$275.88	$253.97 - $306.08
Q2 2020	73,263	$21,269	$271.12	$222.39 - $299.21
Q1 2020	48,136	$11,454	$229.39	$197.47 - $249.85
Q4 2019	106,205	$23,254	$202.38	$165.23 - $225.66
Q3 2019	365,820	$61,977	$176.91	$165.27 - $188.44
Q2 2019	369,880	$67,829	$174.82	$163.68 - $191.71
Q1 2019	455,581	$83,804	$184.70	$160.95 - $195.81
Q4 2018	432,373	$71,643	$173.27	$151.80 - $194.92
Q3 2018	344,373	$66,374	$178.07	$164.70 - $193.78
Q2 2018	341,943	$58,117	$155.01	$144.07 - $172.00
Q1 2018	319,055	$52,000	$163.34	$146.21 - $178.15
Q4 2017	345,555	$51,785	$148.07	$136.50 - $158.04
Q3 2017	189,655	$28,835	$150.51	$125.50 - $167.86
Q2 2017	107,455	$13,848	$120.38	$107.24 - $137.26
Q1 2017	247,523	$27,067	$88.04	$73.34 - $111.88
Q4 2016	85,923	$6,330	$81.37	$71.46 - $97.93
Q3 2016	61,584	$5,371	$94.50	$83.50 - $103.73
Q2 2016	130,733	$11,246	$86.41	$75.92 - $96.49
Q1 2016	201,733	$16,036	$90.45	$75.90 - $124.96
Q4 2015	106,433	$13,392	$120.72	$101.49 - $134.71
Q3 2015	76,210	$7,937	$128.47	$97.45 - $143.45
Q2 2015	73,433	$9,068	$125.98	$113.68 - $137.50
Q1 2015	26,933	$3,177	$119.81	$103.75 - $136.33
Q4 2014	26,933	$3,200	$112.63	$96.43 - $124.35
Q3 2014	26,933	$3,025	$95.21	$84.41 - $116.88
Q2 2014	14,432	$1,366	$70.12	$59.79 - $98.80
Q1 2014	74,214	$5,248	$79.20	$67.49 - $87.77
Q4 2013	101,840	$7,567	$69.64	$58.06 - $78.38
Q3 2013	47,923	$3,634	$79.58	$73.43 - $89.96
Q2 2013	58,684	$4,698	$73.64	$51.28 - $87.47
Q1 2013	53,484	$2,940	$48.01	$42.72 - $55.93