VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CIBC Private Wealth Group, LLC's Holding History (CIK: 0001298088)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 7,087 Value ($000) $3,213 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 6,798 Value ($000) $2,662 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 7,029 Value ($000) $3,129 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 6,562 Value ($000) $3,100 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 6,054 Value ($000) $2,495 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 6,478 Value ($000) $3,013 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 10,782 Value ($000) $5,196 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 2,779 Value ($000) $1,169 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 2,942 Value ($000) $1,197 Avg Close $369.42 Range $341.85 - $413.00

Q2 2023

Shares 1,638 Value ($000) $576 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 1,636 Value ($000) $515 Avg Close $299.93 Range $282.21 - $325.19

Q3 2022

Shares 4,127 Value ($000) $1,195 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 9,176 Value ($000) $2,586 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 21,524 Value ($000) $5,618 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 2,513 Value ($000) $552 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 2,492 Value ($000) $452 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 35,016 Value ($000) $7,060 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 37,428 Value ($000) $8,042 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 28,257 Value ($000) $6,678 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 200,577 Value ($000) $54,581 Avg Close $275.88 Range $253.97 - $306.08

Q1 2020

Shares 161,997 Value ($000) $38,547 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,474 Value ($000) $323 Avg Close $202.38 Range $165.23 - $225.66

Q2 2019

Shares 2,495 Value ($000) $458 Avg Close $174.82 Range $163.68 - $191.71

Q3 2018

Shares 7,653 Value ($000) $1,475 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 454 Value ($000) $77 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 625 Value ($000) $102 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 382 Value ($000) $57 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 11,734 Value ($000) $1,784 Avg Close $150.51 Range $125.50 - $167.86

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	7,087	$3,213	$431.03	$392.50 - $464.44
Q3 2025	6,798	$2,662	$417.92	$362.50 - $484.56
Q2 2025	7,029	$3,129	$460.83	$416.60 - $510.77
Q1 2025	6,562	$3,100	$466.00	$397.25 - $519.68
Q4 2024	6,054	$2,495	$463.53	$377.85 - $519.88
Q3 2024	6,478	$3,013	$480.37	$456.07 - $510.64
Q2 2024	10,782	$5,196	$434.05	$391.01 - $486.43
Q1 2024	2,779	$1,169	$422.74	$403.43 - $448.40
Q4 2023	2,942	$1,197	$369.42	$341.85 - $413.00
Q2 2023	1,638	$576	$336.94	$313.47 - $354.94
Q1 2023	1,636	$515	$299.93	$282.21 - $325.19
Q3 2022	4,127	$1,195	$287.72	$271.61 - $305.95
Q2 2022	9,176	$2,586	$267.66	$233.01 - $293.17
Q1 2022	21,524	$5,618	$237.33	$214.66 - $263.58
Q4 2021	2,513	$552	$194.45	$176.36 - $224.49
Q3 2021	2,492	$452	$195.24	$180.02 - $204.88
Q2 2021	35,016	$7,060	$209.17	$185.33 - $222.78
Q1 2021	37,428	$8,042	$219.65	$204.62 - $242.99
Q4 2020	28,257	$6,678	$229.44	$202.57 - $280.99
Q3 2020	200,577	$54,581	$275.88	$253.97 - $306.08
Q1 2020	161,997	$38,547	$229.39	$197.47 - $249.85
Q4 2019	1,474	$323	$202.38	$165.23 - $225.66
Q2 2019	2,495	$458	$174.82	$163.68 - $191.71
Q3 2018	7,653	$1,475	$178.07	$164.70 - $193.78
Q2 2018	454	$77	$155.01	$144.07 - $172.00
Q1 2018	625	$102	$163.34	$146.21 - $178.15
Q4 2017	382	$57	$148.07	$136.50 - $158.04
Q3 2017	11,734	$1,784	$150.51	$125.50 - $167.86