VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Madison Asset Management, LLC's Holding History (CIK: 0001299351)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 16,435 Value ($000) $7,451 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 16,201 Value ($000) $6,345 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 14,192 Value ($000) $6,318 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 14,396 Value ($000) $6,979 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 14,522 Value ($000) $5,848 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 14,511 Value ($000) $6,749 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 14,640 Value ($000) $6,862 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 14,632 Value ($000) $6,116 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 14,676 Value ($000) $5,972 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 15,014 Value ($000) $5,221 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 15,227 Value ($000) $5,359 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 15,541 Value ($000) $4,897 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 15,825 Value ($000) $5 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 15,747 Value ($000) $4,559 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 15,566 Value ($000) $4,386 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 15,494 Value ($000) $4,043 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 14,728 Value ($000) $3,234 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 15,131 Value ($000) $2,745 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 14,368 Value ($000) $2,897 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 3,835 Value ($000) $824 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 3,400 Value ($000) $804 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 3,000 Value ($000) $816 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 3,000 Value ($000) $871 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 3,000 Value ($000) $714 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 3,000 Value ($000) $657 Avg Close $202.38 Range $165.23 - $225.66

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	16,435	$7,451	$431.03	$392.50 - $464.44
Q3 2025	16,201	$6,345	$417.92	$362.50 - $484.56
Q2 2025	14,192	$6,318	$460.83	$416.60 - $510.77
Q1 2025	14,396	$6,979	$466.00	$397.25 - $519.68
Q4 2024	14,522	$5,848	$463.53	$377.85 - $519.88
Q3 2024	14,511	$6,749	$480.37	$456.07 - $510.64
Q2 2024	14,640	$6,862	$434.05	$391.01 - $486.43
Q1 2024	14,632	$6,116	$422.74	$403.43 - $448.40
Q4 2023	14,676	$5,972	$369.42	$341.85 - $413.00
Q3 2023	15,014	$5,221	$349.73	$335.82 - $367.00
Q2 2023	15,227	$5,359	$336.94	$313.47 - $354.94
Q1 2023	15,541	$4,897	$299.93	$282.21 - $325.19
Q4 2022	15,825	$5	$304.77	$283.58 - $324.75
Q3 2022	15,747	$4,559	$287.72	$271.61 - $305.95
Q2 2022	15,566	$4,386	$267.66	$233.01 - $293.17
Q1 2022	15,494	$4,043	$237.33	$214.66 - $263.58
Q4 2021	14,728	$3,234	$194.45	$176.36 - $224.49
Q3 2021	15,131	$2,745	$195.24	$180.02 - $204.88
Q2 2021	14,368	$2,897	$209.17	$185.33 - $222.78
Q1 2021	3,835	$824	$219.65	$204.62 - $242.99
Q4 2020	3,400	$804	$229.44	$202.57 - $280.99
Q3 2020	3,000	$816	$275.88	$253.97 - $306.08
Q2 2020	3,000	$871	$271.12	$222.39 - $299.21
Q1 2020	3,000	$714	$229.39	$197.47 - $249.85
Q4 2019	3,000	$657	$202.38	$165.23 - $225.66