VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

SG Americas Securities, LLC's Holding History (CIK: 0001313360)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 115,899 Value ($000) $53 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 60,062 Value ($000) $24 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 115,640 Value ($000) $51 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 22,273 Value ($000) $11 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 4,771 Value ($000) $2 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 35,331 Value ($000) $16 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 78,529 Value ($000) $37 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 30,034 Value ($000) $13 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 28,123 Value ($000) $11 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 13,696 Value ($000) $5 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 30,063 Value ($000) $11 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 16,576 Value ($000) $5 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 18,445 Value ($000) $5 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 14,333 Value ($000) $4,150 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 39,617 Value ($000) $11,164 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 75,285 Value ($000) $19,647 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 34,154 Value ($000) $7,500 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 8,260 Value ($000) $1,498 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 123,250 Value ($000) $24,851 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 31,273 Value ($000) $6,720 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 45,269 Value ($000) $10,699 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 29,092 Value ($000) $7,917 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 44,720 Value ($000) $12,983 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 21,767 Value ($000) $5,179 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 20,892 Value ($000) $4,574 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 89,062 Value ($000) $15,089 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 33,991 Value ($000) $6,233 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 16,267 Value ($000) $2,992 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 1,939 Value ($000) $321 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 86,707 Value ($000) $16,712 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 37,858 Value ($000) $6,434 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 66,747 Value ($000) $10,878 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 15,208 Value ($000) $2,279 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 15,282 Value ($000) $2,323 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 13,809 Value ($000) $1,780 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 40,316 Value ($000) $4,409 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 98,705 Value ($000) $7,272 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 23,099 Value ($000) $2,014 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 19,068 Value ($000) $1,640 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 50,502 Value ($000) $4,014 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 112,164 Value ($000) $14,114 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 51,895 Value ($000) $5,404 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 223,832 Value ($000) $27,639 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 128,514 Value ($000) $15,161 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 193,924 Value ($000) $23,038 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 273,421 Value ($000) $30,708 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 243,806 Value ($000) $23,084 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 361,450 Value ($000) $25,562 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 276,291 Value ($000) $20,528 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 532,554 Value ($000) $40,378 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 188,289 Value ($000) $15,039 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	115,899	$53	$431.03	$392.50 - $464.44
Q3 2025	60,062	$24	$417.92	$362.50 - $484.56
Q2 2025	115,640	$51	$460.83	$416.60 - $510.77
Q1 2025	22,273	$11	$466.00	$397.25 - $519.68
Q4 2024	4,771	$2	$463.53	$377.85 - $519.88
Q3 2024	35,331	$16	$480.37	$456.07 - $510.64
Q2 2024	78,529	$37	$434.05	$391.01 - $486.43
Q1 2024	30,034	$13	$422.74	$403.43 - $448.40
Q4 2023	28,123	$11	$369.42	$341.85 - $413.00
Q3 2023	13,696	$5	$349.73	$335.82 - $367.00
Q2 2023	30,063	$11	$336.94	$313.47 - $354.94
Q1 2023	16,576	$5	$299.93	$282.21 - $325.19
Q4 2022	18,445	$5	$304.77	$283.58 - $324.75
Q3 2022	14,333	$4,150	$287.72	$271.61 - $305.95
Q2 2022	39,617	$11,164	$267.66	$233.01 - $293.17
Q1 2022	75,285	$19,647	$237.33	$214.66 - $263.58
Q4 2021	34,154	$7,500	$194.45	$176.36 - $224.49
Q3 2021	8,260	$1,498	$195.24	$180.02 - $204.88
Q2 2021	123,250	$24,851	$209.17	$185.33 - $222.78
Q1 2021	31,273	$6,720	$219.65	$204.62 - $242.99
Q4 2020	45,269	$10,699	$229.44	$202.57 - $280.99
Q3 2020	29,092	$7,917	$275.88	$253.97 - $306.08
Q2 2020	44,720	$12,983	$271.12	$222.39 - $299.21
Q1 2020	21,767	$5,179	$229.39	$197.47 - $249.85
Q4 2019	20,892	$4,574	$202.38	$165.23 - $225.66
Q3 2019	89,062	$15,089	$176.91	$165.27 - $188.44
Q2 2019	33,991	$6,233	$174.82	$163.68 - $191.71
Q1 2019	16,267	$2,992	$184.70	$160.95 - $195.81
Q4 2018	1,939	$321	$173.27	$151.80 - $194.92
Q3 2018	86,707	$16,712	$178.07	$164.70 - $193.78
Q2 2018	37,858	$6,434	$155.01	$144.07 - $172.00
Q1 2018	66,747	$10,878	$163.34	$146.21 - $178.15
Q4 2017	15,208	$2,279	$148.07	$136.50 - $158.04
Q3 2017	15,282	$2,323	$150.51	$125.50 - $167.86
Q2 2017	13,809	$1,780	$120.38	$107.24 - $137.26
Q1 2017	40,316	$4,409	$88.04	$73.34 - $111.88
Q4 2016	98,705	$7,272	$81.37	$71.46 - $97.93
Q3 2016	23,099	$2,014	$94.50	$83.50 - $103.73
Q2 2016	19,068	$1,640	$86.41	$75.92 - $96.49
Q1 2016	50,502	$4,014	$90.45	$75.90 - $124.96
Q4 2015	112,164	$14,114	$120.72	$101.49 - $134.71
Q3 2015	51,895	$5,404	$128.47	$97.45 - $143.45
Q2 2015	223,832	$27,639	$125.98	$113.68 - $137.50
Q1 2015	128,514	$15,161	$119.81	$103.75 - $136.33
Q4 2014	193,924	$23,038	$112.63	$96.43 - $124.35
Q3 2014	273,421	$30,708	$95.21	$84.41 - $116.88
Q2 2014	243,806	$23,084	$70.12	$59.79 - $98.80
Q1 2014	361,450	$25,562	$79.20	$67.49 - $87.77
Q4 2013	276,291	$20,528	$69.64	$58.06 - $78.38
Q3 2013	532,554	$40,378	$79.58	$73.43 - $89.96
Q2 2013	188,289	$15,039	$73.64	$51.28 - $87.47