VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Janney Montgomery Scott LLC's Holding History (CIK: 0001329948)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 70,353 Value ($000) $32 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 77,456 Value ($000) $30 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 71,890 Value ($000) $32 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 68,619 Value ($000) $33 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 92,192 Value ($000) $37 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 127,425 Value ($000) $59 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 129,809 Value ($000) $61 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 122,256 Value ($000) $51 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 128,370 Value ($000) $52 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 121,194 Value ($000) $42 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 126,013 Value ($000) $44 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 125,175 Value ($000) $39 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 128,584 Value ($000) $37 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 107,326 Value ($000) $31,075 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 94,820 Value ($000) $26,308 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 106,911 Value ($000) $27,901 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 54,887 Value ($000) $12,053 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 52,448 Value ($000) $9,514 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 50,503 Value ($000) $10,183 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 56,663 Value ($000) $12,176 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 54,275 Value ($000) $12,827 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 116,448 Value ($000) $31,688 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 106,010 Value ($000) $30,776 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 91,020 Value ($000) $21,658 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 69,837 Value ($000) $15,291 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 36,616 Value ($000) $6,203 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 35,043 Value ($000) $6,426 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 36,860 Value ($000) $6,781 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 39,879 Value ($000) $6,608 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 43,518 Value ($000) $8,388 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 35,401 Value ($000) $6,017 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 36,725 Value ($000) $5,985 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 31,463 Value ($000) $4,715 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 30,936 Value ($000) $4,704 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 26,850 Value ($000) $3,460 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 25,054 Value ($000) $2,740 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 19,119 Value ($000) $1,408 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 13,611 Value ($000) $1,187 Avg Close $94.50 Range $83.50 - $103.73

Q1 2016

Shares 11,616 Value ($000) $923 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 5,211 Value ($000) $656 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 3,335 Value ($000) $347 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 3,257 Value ($000) $402,174 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 2,445 Value ($000) $288 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 2,175 Value ($000) $258,390 Avg Close $112.63 Range $96.43 - $124.35

Q2 2014

Shares 3,827 Value ($000) $362,340 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 4,560 Value ($000) $322,483 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 3,035 Value ($000) $225,501 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 3,367 Value ($000) $255,286 Avg Close $79.58 Range $73.43 - $89.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	70,353	$32	$431.03	$392.50 - $464.44
Q3 2025	77,456	$30	$417.92	$362.50 - $484.56
Q2 2025	71,890	$32	$460.83	$416.60 - $510.77
Q1 2025	68,619	$33	$466.00	$397.25 - $519.68
Q4 2024	92,192	$37	$463.53	$377.85 - $519.88
Q3 2024	127,425	$59	$480.37	$456.07 - $510.64
Q2 2024	129,809	$61	$434.05	$391.01 - $486.43
Q1 2024	122,256	$51	$422.74	$403.43 - $448.40
Q4 2023	128,370	$52	$369.42	$341.85 - $413.00
Q3 2023	121,194	$42	$349.73	$335.82 - $367.00
Q2 2023	126,013	$44	$336.94	$313.47 - $354.94
Q1 2023	125,175	$39	$299.93	$282.21 - $325.19
Q4 2022	128,584	$37	$304.77	$283.58 - $324.75
Q3 2022	107,326	$31,075	$287.72	$271.61 - $305.95
Q2 2022	94,820	$26,308	$267.66	$233.01 - $293.17
Q1 2022	106,911	$27,901	$237.33	$214.66 - $263.58
Q4 2021	54,887	$12,053	$194.45	$176.36 - $224.49
Q3 2021	52,448	$9,514	$195.24	$180.02 - $204.88
Q2 2021	50,503	$10,183	$209.17	$185.33 - $222.78
Q1 2021	56,663	$12,176	$219.65	$204.62 - $242.99
Q4 2020	54,275	$12,827	$229.44	$202.57 - $280.99
Q3 2020	116,448	$31,688	$275.88	$253.97 - $306.08
Q2 2020	106,010	$30,776	$271.12	$222.39 - $299.21
Q1 2020	91,020	$21,658	$229.39	$197.47 - $249.85
Q4 2019	69,837	$15,291	$202.38	$165.23 - $225.66
Q3 2019	36,616	$6,203	$176.91	$165.27 - $188.44
Q2 2019	35,043	$6,426	$174.82	$163.68 - $191.71
Q1 2019	36,860	$6,781	$184.70	$160.95 - $195.81
Q4 2018	39,879	$6,608	$173.27	$151.80 - $194.92
Q3 2018	43,518	$8,388	$178.07	$164.70 - $193.78
Q2 2018	35,401	$6,017	$155.01	$144.07 - $172.00
Q1 2018	36,725	$5,985	$163.34	$146.21 - $178.15
Q4 2017	31,463	$4,715	$148.07	$136.50 - $158.04
Q3 2017	30,936	$4,704	$150.51	$125.50 - $167.86
Q2 2017	26,850	$3,460	$120.38	$107.24 - $137.26
Q1 2017	25,054	$2,740	$88.04	$73.34 - $111.88
Q4 2016	19,119	$1,408	$81.37	$71.46 - $97.93
Q3 2016	13,611	$1,187	$94.50	$83.50 - $103.73
Q1 2016	11,616	$923	$90.45	$75.90 - $124.96
Q4 2015	5,211	$656	$120.72	$101.49 - $134.71
Q3 2015	3,335	$347	$128.47	$97.45 - $143.45
Q2 2015	3,257	$402,174	$125.98	$113.68 - $137.50
Q1 2015	2,445	$288	$119.81	$103.75 - $136.33
Q4 2014	2,175	$258,390	$112.63	$96.43 - $124.35
Q2 2014	3,827	$362,340	$70.12	$59.79 - $98.80
Q1 2014	4,560	$322,483	$79.20	$67.49 - $87.77
Q4 2013	3,035	$225,501	$69.64	$58.06 - $78.38
Q3 2013	3,367	$255,286	$79.58	$73.43 - $89.96