VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

ProShare Advisors LLC's Holding History (CIK: 0001357955)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 457,046 Value ($000) $207,206 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 333,732 Value ($000) $130,703 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 401,244 Value ($000) $178,634 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 383,030 Value ($000) $185,701 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 344,526 Value ($000) $138,741 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 291,410 Value ($000) $135,529 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 269,741 Value ($000) $126,433 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 300,270 Value ($000) $125,516 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 251,571 Value ($000) $102,362 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 296,824 Value ($000) $103,218 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 261,610 Value ($000) $92,063 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 280,095 Value ($000) $88,250 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 255,282 Value ($000) $73,720 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 281,712 Value ($000) $81,567 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 330,326 Value ($000) $93,083 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 488,976 Value ($000) $127,605 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 517,189 Value ($000) $113,574 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 373,152 Value ($000) $67,686 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 339,634 Value ($000) $68,480 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 344,703 Value ($000) $74,073 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 299,736 Value ($000) $70,840 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 262,672 Value ($000) $71,478 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 227,823 Value ($000) $66,139 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 200,514 Value ($000) $47,712 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 286,155 Value ($000) $62,654 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 272,604 Value ($000) $46,185 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 267,962 Value ($000) $49,139 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 296,615 Value ($000) $54,562 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 269,377 Value ($000) $44,638 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 242,974 Value ($000) $46,831 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 268,137 Value ($000) $45,573 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 315,677 Value ($000) $51,449 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 277,825 Value ($000) $41,635 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 217,305 Value ($000) $33,039 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 202,058 Value ($000) $26,039 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 220,101 Value ($000) $24,068 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 272,477 Value ($000) $20,073 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 231,498 Value ($000) $20,189 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 291,169 Value ($000) $25,046 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 285,572 Value ($000) $22,700 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 304,093 Value ($000) $38,264 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 276,749 Value ($000) $28,821 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 277,411 Value ($000) $34,255 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 309,393 Value ($000) $36,499 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 265,231 Value ($000) $31,509 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 204,396 Value ($000) $22,956 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 235,869 Value ($000) $22,332 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 286,040 Value ($000) $20,229 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 188,637 Value ($000) $14,016 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 112,890 Value ($000) $8,559 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 82,960 Value ($000) $6,626 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	457,046	$207,206	$431.03	$392.50 - $464.44
Q3 2025	333,732	$130,703	$417.92	$362.50 - $484.56
Q2 2025	401,244	$178,634	$460.83	$416.60 - $510.77
Q1 2025	383,030	$185,701	$466.00	$397.25 - $519.68
Q4 2024	344,526	$138,741	$463.53	$377.85 - $519.88
Q3 2024	291,410	$135,529	$480.37	$456.07 - $510.64
Q2 2024	269,741	$126,433	$434.05	$391.01 - $486.43
Q1 2024	300,270	$125,516	$422.74	$403.43 - $448.40
Q4 2023	251,571	$102,362	$369.42	$341.85 - $413.00
Q3 2023	296,824	$103,218	$349.73	$335.82 - $367.00
Q2 2023	261,610	$92,063	$336.94	$313.47 - $354.94
Q1 2023	280,095	$88,250	$299.93	$282.21 - $325.19
Q4 2022	255,282	$73,720	$304.77	$283.58 - $324.75
Q3 2022	281,712	$81,567	$287.72	$271.61 - $305.95
Q2 2022	330,326	$93,083	$267.66	$233.01 - $293.17
Q1 2022	488,976	$127,605	$237.33	$214.66 - $263.58
Q4 2021	517,189	$113,574	$194.45	$176.36 - $224.49
Q3 2021	373,152	$67,686	$195.24	$180.02 - $204.88
Q2 2021	339,634	$68,480	$209.17	$185.33 - $222.78
Q1 2021	344,703	$74,073	$219.65	$204.62 - $242.99
Q4 2020	299,736	$70,840	$229.44	$202.57 - $280.99
Q3 2020	262,672	$71,478	$275.88	$253.97 - $306.08
Q2 2020	227,823	$66,139	$271.12	$222.39 - $299.21
Q1 2020	200,514	$47,712	$229.39	$197.47 - $249.85
Q4 2019	286,155	$62,654	$202.38	$165.23 - $225.66
Q3 2019	272,604	$46,185	$176.91	$165.27 - $188.44
Q2 2019	267,962	$49,139	$174.82	$163.68 - $191.71
Q1 2019	296,615	$54,562	$184.70	$160.95 - $195.81
Q4 2018	269,377	$44,638	$173.27	$151.80 - $194.92
Q3 2018	242,974	$46,831	$178.07	$164.70 - $193.78
Q2 2018	268,137	$45,573	$155.01	$144.07 - $172.00
Q1 2018	315,677	$51,449	$163.34	$146.21 - $178.15
Q4 2017	277,825	$41,635	$148.07	$136.50 - $158.04
Q3 2017	217,305	$33,039	$150.51	$125.50 - $167.86
Q2 2017	202,058	$26,039	$120.38	$107.24 - $137.26
Q1 2017	220,101	$24,068	$88.04	$73.34 - $111.88
Q4 2016	272,477	$20,073	$81.37	$71.46 - $97.93
Q3 2016	231,498	$20,189	$94.50	$83.50 - $103.73
Q2 2016	291,169	$25,046	$86.41	$75.92 - $96.49
Q1 2016	285,572	$22,700	$90.45	$75.90 - $124.96
Q4 2015	304,093	$38,264	$120.72	$101.49 - $134.71
Q3 2015	276,749	$28,821	$128.47	$97.45 - $143.45
Q2 2015	277,411	$34,255	$125.98	$113.68 - $137.50
Q1 2015	309,393	$36,499	$119.81	$103.75 - $136.33
Q4 2014	265,231	$31,509	$112.63	$96.43 - $124.35
Q3 2014	204,396	$22,956	$95.21	$84.41 - $116.88
Q2 2014	235,869	$22,332	$70.12	$59.79 - $98.80
Q1 2014	286,040	$20,229	$79.20	$67.49 - $87.77
Q4 2013	188,637	$14,016	$69.64	$58.06 - $78.38
Q3 2013	112,890	$8,559	$79.58	$73.43 - $89.96
Q2 2013	82,960	$6,626	$73.64	$51.28 - $87.47