VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

MACQUARIE GROUP LTD's Holding History (CIK: 0001418333)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 44,736 Value ($000) $20,282 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 223,556 Value ($000) $87,553 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 228,853 Value ($000) $101,885 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 234,136 Value ($000) $113,514 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 229,933 Value ($000) $88,704 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 326,516 Value ($000) $151,856 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 335,745 Value ($000) $157,370 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 372,241 Value ($000) $155,601 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 397,294 Value ($000) $161,655 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 730,933 Value ($000) $254,174 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 714,435 Value ($000) $251,417 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 766,374 Value ($000) $241,461 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 859,300 Value ($000) $248,149 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 897,308 Value ($000) $259,807 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 933,179 Value ($000) $262,961 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 280,858 Value ($000) $73,296 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 304,257 Value ($000) $66,815 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,350,515 Value ($000) $244,970 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 1,616,774 Value ($000) $325,990 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 150,487 Value ($000) $32,338 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 136,103 Value ($000) $32,166 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 130,364 Value ($000) $35,475 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 110,927 Value ($000) $32,203 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 109,120 Value ($000) $25,965 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 124,129 Value ($000) $27,179 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 139,641 Value ($000) $23,658 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 136,591 Value ($000) $25,048 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 155,810 Value ($000) $28,661 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 159,350 Value ($000) $26,406 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 153,637 Value ($000) $29,612 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 167,127 Value ($000) $28,405 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 180,732 Value ($000) $29,455 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 168,273 Value ($000) $24,861 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 224,274 Value ($000) $34,099 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 207,347 Value ($000) $26,721 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 210,395 Value ($000) $23,007 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 235,647 Value ($000) $17,360 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 264,096 Value ($000) $23,032 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 263,816 Value ($000) $22,693 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 287,681 Value ($000) $22,868 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 249,630 Value ($000) $31,415 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 240,690 Value ($000) $25,066 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 162,040 Value ($000) $20,009 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 226,357 Value ($000) $26,703 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 220,010 Value ($000) $26,138 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 231,205 Value ($000) $25,967 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 249,539 Value ($000) $23,626 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 359,559 Value ($000) $25,428 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 324,449 Value ($000) $24,107 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 325,769 Value ($000) $24,699 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 323,369 Value ($000) $25,830 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	44,736	$20,282	$431.03	$392.50 - $464.44
Q3 2025	223,556	$87,553	$417.92	$362.50 - $484.56
Q2 2025	228,853	$101,885	$460.83	$416.60 - $510.77
Q1 2025	234,136	$113,514	$466.00	$397.25 - $519.68
Q4 2024	229,933	$88,704	$463.53	$377.85 - $519.88
Q3 2024	326,516	$151,856	$480.37	$456.07 - $510.64
Q2 2024	335,745	$157,370	$434.05	$391.01 - $486.43
Q1 2024	372,241	$155,601	$422.74	$403.43 - $448.40
Q4 2023	397,294	$161,655	$369.42	$341.85 - $413.00
Q3 2023	730,933	$254,174	$349.73	$335.82 - $367.00
Q2 2023	714,435	$251,417	$336.94	$313.47 - $354.94
Q1 2023	766,374	$241,461	$299.93	$282.21 - $325.19
Q4 2022	859,300	$248,149	$304.77	$283.58 - $324.75
Q3 2022	897,308	$259,807	$287.72	$271.61 - $305.95
Q2 2022	933,179	$262,961	$267.66	$233.01 - $293.17
Q1 2022	280,858	$73,296	$237.33	$214.66 - $263.58
Q4 2021	304,257	$66,815	$194.45	$176.36 - $224.49
Q3 2021	1,350,515	$244,970	$195.24	$180.02 - $204.88
Q2 2021	1,616,774	$325,990	$209.17	$185.33 - $222.78
Q1 2021	150,487	$32,338	$219.65	$204.62 - $242.99
Q4 2020	136,103	$32,166	$229.44	$202.57 - $280.99
Q3 2020	130,364	$35,475	$275.88	$253.97 - $306.08
Q2 2020	110,927	$32,203	$271.12	$222.39 - $299.21
Q1 2020	109,120	$25,965	$229.39	$197.47 - $249.85
Q4 2019	124,129	$27,179	$202.38	$165.23 - $225.66
Q3 2019	139,641	$23,658	$176.91	$165.27 - $188.44
Q2 2019	136,591	$25,048	$174.82	$163.68 - $191.71
Q1 2019	155,810	$28,661	$184.70	$160.95 - $195.81
Q4 2018	159,350	$26,406	$173.27	$151.80 - $194.92
Q3 2018	153,637	$29,612	$178.07	$164.70 - $193.78
Q2 2018	167,127	$28,405	$155.01	$144.07 - $172.00
Q1 2018	180,732	$29,455	$163.34	$146.21 - $178.15
Q4 2017	168,273	$24,861	$148.07	$136.50 - $158.04
Q3 2017	224,274	$34,099	$150.51	$125.50 - $167.86
Q2 2017	207,347	$26,721	$120.38	$107.24 - $137.26
Q1 2017	210,395	$23,007	$88.04	$73.34 - $111.88
Q4 2016	235,647	$17,360	$81.37	$71.46 - $97.93
Q3 2016	264,096	$23,032	$94.50	$83.50 - $103.73
Q2 2016	263,816	$22,693	$86.41	$75.92 - $96.49
Q1 2016	287,681	$22,868	$90.45	$75.90 - $124.96
Q4 2015	249,630	$31,415	$120.72	$101.49 - $134.71
Q3 2015	240,690	$25,066	$128.47	$97.45 - $143.45
Q2 2015	162,040	$20,009	$125.98	$113.68 - $137.50
Q1 2015	226,357	$26,703	$119.81	$103.75 - $136.33
Q4 2014	220,010	$26,138	$112.63	$96.43 - $124.35
Q3 2014	231,205	$25,967	$95.21	$84.41 - $116.88
Q2 2014	249,539	$23,626	$70.12	$59.79 - $98.80
Q1 2014	359,559	$25,428	$79.20	$67.49 - $87.77
Q4 2013	324,449	$24,107	$69.64	$58.06 - $78.38
Q3 2013	325,769	$24,699	$79.58	$73.43 - $89.96
Q2 2013	323,369	$25,830	$73.64	$51.28 - $87.47