VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Robeco Institutional Asset Management B.V.'s Holding History (CIK: 0001418773)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 394,200 Value ($000) $178,715 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 379,371 Value ($000) $148,577 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 329,391 Value ($000) $146,645 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 146,000 Value ($000) $70,784 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 286,756 Value ($000) $115,477 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 296,568 Value ($000) $137,928 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 370,211 Value ($000) $173,525 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 463,869 Value ($000) $193,902 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 457,824 Value ($000) $186,284 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 432,937 Value ($000) $150,550 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 406,414 Value ($000) $143,021 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 446,817 Value ($000) $140,779 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 471,957 Value ($000) $136,292 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 339,030 Value ($000) $98,162 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 254,027 Value ($000) $71,580 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 236,832 Value ($000) $61,805 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 198,318 Value ($000) $43,551 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 202,955 Value ($000) $36,812 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 203,087 Value ($000) $40,950 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 176,492 Value ($000) $37,927 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 288,497 Value ($000) $68,184 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 355,889 Value ($000) $96,844 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 308,352 Value ($000) $89,517 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 79,973 Value ($000) $19,029 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 32,648 Value ($000) $7,149 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 28,710 Value ($000) $4,863 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 37,692 Value ($000) $6,914 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 40,986 Value ($000) $7,540 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 25,203 Value ($000) $4,176 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 37,215 Value ($000) $7,174 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 34,579 Value ($000) $5,878 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 36,628 Value ($000) $5,968 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 26,688 Value ($000) $4,000 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 15,672 Value ($000) $2,382 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 15,633 Value ($000) $2,013 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 961 Value ($000) $105 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 961 Value ($000) $71 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 961 Value ($000) $84 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 10,728 Value ($000) $923 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 10,728 Value ($000) $853 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 10,728 Value ($000) $1,350 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 8,123 Value ($000) $846 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 8,123 Value ($000) $1,003 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 463 Value ($000) $55 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 6,686 Value ($000) $794 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 4,094 Value ($000) $460 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 3,370 Value ($000) $319 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 1,849 Value ($000) $131 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 1,307 Value ($000) $97 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 1,307 Value ($000) $99 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 1,307 Value ($000) $104 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	394,200	$178,715	$431.03	$392.50 - $464.44
Q3 2025	379,371	$148,577	$417.92	$362.50 - $484.56
Q2 2025	329,391	$146,645	$460.83	$416.60 - $510.77
Q1 2025	146,000	$70,784	$466.00	$397.25 - $519.68
Q4 2024	286,756	$115,477	$463.53	$377.85 - $519.88
Q3 2024	296,568	$137,928	$480.37	$456.07 - $510.64
Q2 2024	370,211	$173,525	$434.05	$391.01 - $486.43
Q1 2024	463,869	$193,902	$422.74	$403.43 - $448.40
Q4 2023	457,824	$186,284	$369.42	$341.85 - $413.00
Q3 2023	432,937	$150,550	$349.73	$335.82 - $367.00
Q2 2023	406,414	$143,021	$336.94	$313.47 - $354.94
Q1 2023	446,817	$140,779	$299.93	$282.21 - $325.19
Q4 2022	471,957	$136,292	$304.77	$283.58 - $324.75
Q3 2022	339,030	$98,162	$287.72	$271.61 - $305.95
Q2 2022	254,027	$71,580	$267.66	$233.01 - $293.17
Q1 2022	236,832	$61,805	$237.33	$214.66 - $263.58
Q4 2021	198,318	$43,551	$194.45	$176.36 - $224.49
Q3 2021	202,955	$36,812	$195.24	$180.02 - $204.88
Q2 2021	203,087	$40,950	$209.17	$185.33 - $222.78
Q1 2021	176,492	$37,927	$219.65	$204.62 - $242.99
Q4 2020	288,497	$68,184	$229.44	$202.57 - $280.99
Q3 2020	355,889	$96,844	$275.88	$253.97 - $306.08
Q2 2020	308,352	$89,517	$271.12	$222.39 - $299.21
Q1 2020	79,973	$19,029	$229.39	$197.47 - $249.85
Q4 2019	32,648	$7,149	$202.38	$165.23 - $225.66
Q3 2019	28,710	$4,863	$176.91	$165.27 - $188.44
Q2 2019	37,692	$6,914	$174.82	$163.68 - $191.71
Q1 2019	40,986	$7,540	$184.70	$160.95 - $195.81
Q4 2018	25,203	$4,176	$173.27	$151.80 - $194.92
Q3 2018	37,215	$7,174	$178.07	$164.70 - $193.78
Q2 2018	34,579	$5,878	$155.01	$144.07 - $172.00
Q1 2018	36,628	$5,968	$163.34	$146.21 - $178.15
Q4 2017	26,688	$4,000	$148.07	$136.50 - $158.04
Q3 2017	15,672	$2,382	$150.51	$125.50 - $167.86
Q2 2017	15,633	$2,013	$120.38	$107.24 - $137.26
Q1 2017	961	$105	$88.04	$73.34 - $111.88
Q4 2016	961	$71	$81.37	$71.46 - $97.93
Q3 2016	961	$84	$94.50	$83.50 - $103.73
Q2 2016	10,728	$923	$86.41	$75.92 - $96.49
Q1 2016	10,728	$853	$90.45	$75.90 - $124.96
Q4 2015	10,728	$1,350	$120.72	$101.49 - $134.71
Q3 2015	8,123	$846	$128.47	$97.45 - $143.45
Q2 2015	8,123	$1,003	$125.98	$113.68 - $137.50
Q1 2015	463	$55	$119.81	$103.75 - $136.33
Q4 2014	6,686	$794	$112.63	$96.43 - $124.35
Q3 2014	4,094	$460	$95.21	$84.41 - $116.88
Q2 2014	3,370	$319	$70.12	$59.79 - $98.80
Q1 2014	1,849	$131	$79.20	$67.49 - $87.77
Q4 2013	1,307	$97	$69.64	$58.06 - $78.38
Q3 2013	1,307	$99	$79.58	$73.43 - $89.96
Q2 2013	1,307	$104	$73.64	$51.28 - $87.47