VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Cambridge Investment Research Advisors, Inc.'s Holding History (CIK: 0001419186)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 14,357 Value ($000) $7 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 14,117 Value ($000) $6 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 17,329 Value ($000) $8 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 16,331 Value ($000) $8 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 12,581 Value ($000) $5 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 14,517 Value ($000) $7 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 13,923 Value ($000) $7 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 18,675 Value ($000) $8 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 15,862 Value ($000) $6 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 13,059 Value ($000) $5 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 13,038 Value ($000) $5 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 12,583 Value ($000) $4 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 13,457 Value ($000) $4 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 14,452 Value ($000) $4,184 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 14,002 Value ($000) $3,946 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 12,947 Value ($000) $3,379 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 12,189 Value ($000) $2,677 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 12,234 Value ($000) $2,219 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 13,272 Value ($000) $2,676 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 12,179 Value ($000) $2,617 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 9,256 Value ($000) $2,188 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 8,822 Value ($000) $2,401 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 21,848 Value ($000) $6,343 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 10,620 Value ($000) $2,527 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 8,553 Value ($000) $1,873 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 7,378 Value ($000) $1,250 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 7,398 Value ($000) $1,357 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 7,344 Value ($000) $1,351 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 7,063 Value ($000) $1,170 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 7,462 Value ($000) $1,438 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 6,011 Value ($000) $1,022 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 5,941 Value ($000) $968 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 6,324 Value ($000) $948 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 7,625 Value ($000) $1,159 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 6,383 Value ($000) $823 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 6,282 Value ($000) $687 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 6,300 Value ($000) $464 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 6,304 Value ($000) $550 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 6,688 Value ($000) $575 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 6,552 Value ($000) $521 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 7,844 Value ($000) $987 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 8,455 Value ($000) $881 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 11,439 Value ($000) $1,412 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 7,896 Value ($000) $931 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 8,451 Value ($000) $1,004 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 9,391 Value ($000) $1,055 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 8,311 Value ($000) $787 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 9,249 Value ($000) $654 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 14,012 Value ($000) $1,041 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 16,455 Value ($000) $1,248 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 16,307 Value ($000) $1,306 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	14,357	$7	$431.03	$392.50 - $464.44
Q3 2025	14,117	$6	$417.92	$362.50 - $484.56
Q2 2025	17,329	$8	$460.83	$416.60 - $510.77
Q1 2025	16,331	$8	$466.00	$397.25 - $519.68
Q4 2024	12,581	$5	$463.53	$377.85 - $519.88
Q3 2024	14,517	$7	$480.37	$456.07 - $510.64
Q2 2024	13,923	$7	$434.05	$391.01 - $486.43
Q1 2024	18,675	$8	$422.74	$403.43 - $448.40
Q4 2023	15,862	$6	$369.42	$341.85 - $413.00
Q3 2023	13,059	$5	$349.73	$335.82 - $367.00
Q2 2023	13,038	$5	$336.94	$313.47 - $354.94
Q1 2023	12,583	$4	$299.93	$282.21 - $325.19
Q4 2022	13,457	$4	$304.77	$283.58 - $324.75
Q3 2022	14,452	$4,184	$287.72	$271.61 - $305.95
Q2 2022	14,002	$3,946	$267.66	$233.01 - $293.17
Q1 2022	12,947	$3,379	$237.33	$214.66 - $263.58
Q4 2021	12,189	$2,677	$194.45	$176.36 - $224.49
Q3 2021	12,234	$2,219	$195.24	$180.02 - $204.88
Q2 2021	13,272	$2,676	$209.17	$185.33 - $222.78
Q1 2021	12,179	$2,617	$219.65	$204.62 - $242.99
Q4 2020	9,256	$2,188	$229.44	$202.57 - $280.99
Q3 2020	8,822	$2,401	$275.88	$253.97 - $306.08
Q2 2020	21,848	$6,343	$271.12	$222.39 - $299.21
Q1 2020	10,620	$2,527	$229.39	$197.47 - $249.85
Q4 2019	8,553	$1,873	$202.38	$165.23 - $225.66
Q3 2019	7,378	$1,250	$176.91	$165.27 - $188.44
Q2 2019	7,398	$1,357	$174.82	$163.68 - $191.71
Q1 2019	7,344	$1,351	$184.70	$160.95 - $195.81
Q4 2018	7,063	$1,170	$173.27	$151.80 - $194.92
Q3 2018	7,462	$1,438	$178.07	$164.70 - $193.78
Q2 2018	6,011	$1,022	$155.01	$144.07 - $172.00
Q1 2018	5,941	$968	$163.34	$146.21 - $178.15
Q4 2017	6,324	$948	$148.07	$136.50 - $158.04
Q3 2017	7,625	$1,159	$150.51	$125.50 - $167.86
Q2 2017	6,383	$823	$120.38	$107.24 - $137.26
Q1 2017	6,282	$687	$88.04	$73.34 - $111.88
Q4 2016	6,300	$464	$81.37	$71.46 - $97.93
Q3 2016	6,304	$550	$94.50	$83.50 - $103.73
Q2 2016	6,688	$575	$86.41	$75.92 - $96.49
Q1 2016	6,552	$521	$90.45	$75.90 - $124.96
Q4 2015	7,844	$987	$120.72	$101.49 - $134.71
Q3 2015	8,455	$881	$128.47	$97.45 - $143.45
Q2 2015	11,439	$1,412	$125.98	$113.68 - $137.50
Q1 2015	7,896	$931	$119.81	$103.75 - $136.33
Q4 2014	8,451	$1,004	$112.63	$96.43 - $124.35
Q3 2014	9,391	$1,055	$95.21	$84.41 - $116.88
Q2 2014	8,311	$787	$70.12	$59.79 - $98.80
Q1 2014	9,249	$654	$79.20	$67.49 - $87.77
Q4 2013	14,012	$1,041	$69.64	$58.06 - $78.38
Q3 2013	16,455	$1,248	$79.58	$73.43 - $89.96
Q2 2013	16,307	$1,306	$73.64	$51.28 - $87.47