VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Capital Research Global Investors's Holding History (CIK: 0001422848)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 17,316,344 Value ($000) $7,850,544 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 16,553,281 Value ($000) $6,482,978 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 16,108,291 Value ($000) $7,171,364 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 14,536,344 Value ($000) $7,047,591 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 10,428,951 Value ($000) $4,199,713 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 9,002,205 Value ($000) $4,186,729 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 8,539,339 Value ($000) $4,002,584 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 5,743,882 Value ($000) $2,401,000 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 3,567,664 Value ($000) $1,451,647 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 3,372,584 Value ($000) $1,172,782 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 3,061,676 Value ($000) $1,077,434 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 809,895 Value ($000) $255,174 Avg Close $299.93 Range $282.21 - $325.19

Q3 2020

Shares 1,250,658 Value ($000) $340,329 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,250,659 Value ($000) $363,079 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 1,250,664 Value ($000) $297,595 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,250,649 Value ($000) $273,830 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 1,250,270 Value ($000) $211,821 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 1,250,248 Value ($000) $229,270 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 1,250,000 Value ($000) $229,938 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 2,065,018 Value ($000) $342,194 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 2,655,018 Value ($000) $511,728 Avg Close $178.07 Range $164.70 - $193.78

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	17,316,344	$7,850,544	$431.03	$392.50 - $464.44
Q3 2025	16,553,281	$6,482,978	$417.92	$362.50 - $484.56
Q2 2025	16,108,291	$7,171,364	$460.83	$416.60 - $510.77
Q1 2025	14,536,344	$7,047,591	$466.00	$397.25 - $519.68
Q4 2024	10,428,951	$4,199,713	$463.53	$377.85 - $519.88
Q3 2024	9,002,205	$4,186,729	$480.37	$456.07 - $510.64
Q2 2024	8,539,339	$4,002,584	$434.05	$391.01 - $486.43
Q1 2024	5,743,882	$2,401,000	$422.74	$403.43 - $448.40
Q4 2023	3,567,664	$1,451,647	$369.42	$341.85 - $413.00
Q3 2023	3,372,584	$1,172,782	$349.73	$335.82 - $367.00
Q2 2023	3,061,676	$1,077,434	$336.94	$313.47 - $354.94
Q1 2023	809,895	$255,174	$299.93	$282.21 - $325.19
Q3 2020	1,250,658	$340,329	$275.88	$253.97 - $306.08
Q2 2020	1,250,659	$363,079	$271.12	$222.39 - $299.21
Q1 2020	1,250,664	$297,595	$229.39	$197.47 - $249.85
Q4 2019	1,250,649	$273,830	$202.38	$165.23 - $225.66
Q3 2019	1,250,270	$211,821	$176.91	$165.27 - $188.44
Q2 2019	1,250,248	$229,270	$174.82	$163.68 - $191.71
Q1 2019	1,250,000	$229,938	$184.70	$160.95 - $195.81
Q4 2018	2,065,018	$342,194	$173.27	$151.80 - $194.92
Q3 2018	2,655,018	$511,728	$178.07	$164.70 - $193.78