VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CITADEL ADVISORS LLC's Holding History (CIK: 0001423053)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 427,060 Value ($000) $193,612 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 173,502 Value ($000) $67,950 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 28,827 Value ($000) $12,834 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 5,019 Value ($000) $2,433 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 162,181 Value ($000) $65,310 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 50,232 Value ($000) $23,362 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 104,595 Value ($000) $49,026 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 81,973 Value ($000) $34,266 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 326,680 Value ($000) $132,923 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 27,744 Value ($000) $9,648 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 113 Value ($000) $40 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 83,806 Value ($000) $26,405 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 203,611 Value ($000) $58,799 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 13,765 Value ($000) $3,986 Avg Close $287.72 Range $271.61 - $305.95

Q1 2022

Shares 42,605 Value ($000) $11,119 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 252,591 Value ($000) $55,469 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 414,129 Value ($000) $75,119 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 389,590 Value ($000) $78,553 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,719,180 Value ($000) $369,435 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,478,359 Value ($000) $349,395 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 912,012 Value ($000) $248,177 Avg Close $275.88 Range $253.97 - $306.08

Q1 2020

Shares 446,956 Value ($000) $106,353 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 1,030,835 Value ($000) $225,702 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 714,739 Value ($000) $121,091 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 140,870 Value ($000) $25,833 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 137,571 Value ($000) $25,306 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 883,523 Value ($000) $146,409 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 828,833 Value ($000) $159,749 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 1,525,393 Value ($000) $259,255 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 775,674 Value ($000) $126,420 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 1,714,260 Value ($000) $256,898 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 1,347,609 Value ($000) $204,891 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 1,625,053 Value ($000) $209,420 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 1,027,654 Value ($000) $112,374 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 33,809 Value ($000) $2,491 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 2,537 Value ($000) $221 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 55,154 Value ($000) $4,744 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 290,242 Value ($000) $23,072 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 708,486 Value ($000) $89,148 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 2,348,870 Value ($000) $244,611 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 449,061 Value ($000) $55,450 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 441,796 Value ($000) $52,119 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 682,412 Value ($000) $81,071 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 120,636 Value ($000) $13,549 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 228,799 Value ($000) $21,662 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 57,550 Value ($000) $4,070 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 274,449 Value ($000) $20,391 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 11,387 Value ($000) $864 Avg Close $79.58 Range $73.43 - $89.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	427,060	$193,612	$431.03	$392.50 - $464.44
Q3 2025	173,502	$67,950	$417.92	$362.50 - $484.56
Q2 2025	28,827	$12,834	$460.83	$416.60 - $510.77
Q1 2025	5,019	$2,433	$466.00	$397.25 - $519.68
Q4 2024	162,181	$65,310	$463.53	$377.85 - $519.88
Q3 2024	50,232	$23,362	$480.37	$456.07 - $510.64
Q2 2024	104,595	$49,026	$434.05	$391.01 - $486.43
Q1 2024	81,973	$34,266	$422.74	$403.43 - $448.40
Q4 2023	326,680	$132,923	$369.42	$341.85 - $413.00
Q3 2023	27,744	$9,648	$349.73	$335.82 - $367.00
Q2 2023	113	$40	$336.94	$313.47 - $354.94
Q1 2023	83,806	$26,405	$299.93	$282.21 - $325.19
Q4 2022	203,611	$58,799	$304.77	$283.58 - $324.75
Q3 2022	13,765	$3,986	$287.72	$271.61 - $305.95
Q1 2022	42,605	$11,119	$237.33	$214.66 - $263.58
Q4 2021	252,591	$55,469	$194.45	$176.36 - $224.49
Q3 2021	414,129	$75,119	$195.24	$180.02 - $204.88
Q2 2021	389,590	$78,553	$209.17	$185.33 - $222.78
Q1 2021	1,719,180	$369,435	$219.65	$204.62 - $242.99
Q4 2020	1,478,359	$349,395	$229.44	$202.57 - $280.99
Q3 2020	912,012	$248,177	$275.88	$253.97 - $306.08
Q1 2020	446,956	$106,353	$229.39	$197.47 - $249.85
Q4 2019	1,030,835	$225,702	$202.38	$165.23 - $225.66
Q3 2019	714,739	$121,091	$176.91	$165.27 - $188.44
Q2 2019	140,870	$25,833	$174.82	$163.68 - $191.71
Q1 2019	137,571	$25,306	$184.70	$160.95 - $195.81
Q4 2018	883,523	$146,409	$173.27	$151.80 - $194.92
Q3 2018	828,833	$159,749	$178.07	$164.70 - $193.78
Q2 2018	1,525,393	$259,255	$155.01	$144.07 - $172.00
Q1 2018	775,674	$126,420	$163.34	$146.21 - $178.15
Q4 2017	1,714,260	$256,898	$148.07	$136.50 - $158.04
Q3 2017	1,347,609	$204,891	$150.51	$125.50 - $167.86
Q2 2017	1,625,053	$209,420	$120.38	$107.24 - $137.26
Q1 2017	1,027,654	$112,374	$88.04	$73.34 - $111.88
Q4 2016	33,809	$2,491	$81.37	$71.46 - $97.93
Q3 2016	2,537	$221	$94.50	$83.50 - $103.73
Q2 2016	55,154	$4,744	$86.41	$75.92 - $96.49
Q1 2016	290,242	$23,072	$90.45	$75.90 - $124.96
Q4 2015	708,486	$89,148	$120.72	$101.49 - $134.71
Q3 2015	2,348,870	$244,611	$128.47	$97.45 - $143.45
Q2 2015	449,061	$55,450	$125.98	$113.68 - $137.50
Q1 2015	441,796	$52,119	$119.81	$103.75 - $136.33
Q4 2014	682,412	$81,071	$112.63	$96.43 - $124.35
Q3 2014	120,636	$13,549	$95.21	$84.41 - $116.88
Q2 2014	228,799	$21,662	$70.12	$59.79 - $98.80
Q1 2014	57,550	$4,070	$79.20	$67.49 - $87.77
Q4 2013	274,449	$20,391	$69.64	$58.06 - $78.38
Q3 2013	11,387	$864	$79.58	$73.43 - $89.96