VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

O'SHAUGHNESSY ASSET MANAGEMENT, LLC's Holding History (CIK: 0001423442)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 47,245 Value ($000) $21,419 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 35,681 Value ($000) $13,974 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 34,259 Value ($000) $15,252 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 35,600 Value ($000) $17,260 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 29,154 Value ($000) $11,740 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 28,682 Value ($000) $13,906 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 24,395 Value ($000) $11,434 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 19,698 Value ($000) $8,234 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 16,069 Value ($000) $6,538 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 13,308 Value ($000) $4,628 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 10,062 Value ($000) $3,541 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 7,766 Value ($000) $2,447 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 8,476 Value ($000) $2,448 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 7,986 Value ($000) $2,312 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 5,462 Value ($000) $1,539 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 3,223 Value ($000) $841 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 1,501 Value ($000) $330 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,003 Value ($000) $182 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 925 Value ($000) $187 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,321 Value ($000) $284 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,737 Value ($000) $411 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 2,119 Value ($000) $577 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,814 Value ($000) $527 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 255 Value ($000) $61 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 494 Value ($000) $108 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 1 Value ($000) $0 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 1 Value ($000) $0 Avg Close $174.82 Range $163.68 - $191.71

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	47,245	$21,419	$431.03	$392.50 - $464.44
Q3 2025	35,681	$13,974	$417.92	$362.50 - $484.56
Q2 2025	34,259	$15,252	$460.83	$416.60 - $510.77
Q1 2025	35,600	$17,260	$466.00	$397.25 - $519.68
Q4 2024	29,154	$11,740	$463.53	$377.85 - $519.88
Q3 2024	28,682	$13,906	$480.37	$456.07 - $510.64
Q2 2024	24,395	$11,434	$434.05	$391.01 - $486.43
Q1 2024	19,698	$8,234	$422.74	$403.43 - $448.40
Q4 2023	16,069	$6,538	$369.42	$341.85 - $413.00
Q3 2023	13,308	$4,628	$349.73	$335.82 - $367.00
Q2 2023	10,062	$3,541	$336.94	$313.47 - $354.94
Q1 2023	7,766	$2,447	$299.93	$282.21 - $325.19
Q4 2022	8,476	$2,448	$304.77	$283.58 - $324.75
Q3 2022	7,986	$2,312	$287.72	$271.61 - $305.95
Q2 2022	5,462	$1,539	$267.66	$233.01 - $293.17
Q1 2022	3,223	$841	$237.33	$214.66 - $263.58
Q4 2021	1,501	$330	$194.45	$176.36 - $224.49
Q3 2021	1,003	$182	$195.24	$180.02 - $204.88
Q2 2021	925	$187	$209.17	$185.33 - $222.78
Q1 2021	1,321	$284	$219.65	$204.62 - $242.99
Q4 2020	1,737	$411	$229.44	$202.57 - $280.99
Q3 2020	2,119	$577	$275.88	$253.97 - $306.08
Q2 2020	1,814	$527	$271.12	$222.39 - $299.21
Q1 2020	255	$61	$229.39	$197.47 - $249.85
Q4 2019	494	$108	$202.38	$165.23 - $225.66
Q3 2019	1	$0	$176.91	$165.27 - $188.44
Q2 2019	1	$0	$174.82	$163.68 - $191.71