VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

CAPSTONE INVESTMENT ADVISORS, LLC's Holding History (CIK: 0001426196)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,239 Value ($000) $1,468 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 6,023 Value ($000) $2,359 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 2,359 Value ($000) $1,050 Avg Close $460.83 Range $416.60 - $510.77

Q4 2024

Shares 7,980 Value ($000) $3,214 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 870 Value ($000) $405 Avg Close $480.37 Range $456.07 - $510.64

Q1 2024

Shares 4,359 Value ($000) $1,822 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 1,346 Value ($000) $548 Avg Close $369.42 Range $341.85 - $413.00

Q1 2023

Shares 3,063 Value ($000) $965 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 969 Value ($000) $280 Avg Close $304.77 Range $283.58 - $324.75

Q2 2022

Shares 1,193 Value ($000) $336 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 1 Value ($000) $0 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 12,060 Value ($000) $2,648 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 101,316 Value ($000) $18,378 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 35,422 Value ($000) $7,142 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 12,608 Value ($000) $2,709 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 32,087 Value ($000) $7,583 Avg Close $229.44 Range $202.57 - $280.99

Q3 2019

Shares 158 Value ($000) $27 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 5,382 Value ($000) $987 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 5,947 Value ($000) $1,094 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 158 Value ($000) $26 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 1,902 Value ($000) $367 Avg Close $178.07 Range $164.70 - $193.78

Q3 2017

Shares 2,600 Value ($000) $395 Avg Close $150.51 Range $125.50 - $167.86

Q3 2016

Shares 28,284 Value ($000) $2,466 Avg Close $94.50 Range $83.50 - $103.73

Q1 2016

Shares 4,600 Value ($000) $365 Avg Close $90.45 Range $75.90 - $124.96

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,239	$1,468	$431.03	$392.50 - $464.44
Q3 2025	6,023	$2,359	$417.92	$362.50 - $484.56
Q2 2025	2,359	$1,050	$460.83	$416.60 - $510.77
Q4 2024	7,980	$3,214	$463.53	$377.85 - $519.88
Q3 2024	870	$405	$480.37	$456.07 - $510.64
Q1 2024	4,359	$1,822	$422.74	$403.43 - $448.40
Q4 2023	1,346	$548	$369.42	$341.85 - $413.00
Q1 2023	3,063	$965	$299.93	$282.21 - $325.19
Q4 2022	969	$280	$304.77	$283.58 - $324.75
Q2 2022	1,193	$336	$267.66	$233.01 - $293.17
Q1 2022	1	$0	$237.33	$214.66 - $263.58
Q4 2021	12,060	$2,648	$194.45	$176.36 - $224.49
Q3 2021	101,316	$18,378	$195.24	$180.02 - $204.88
Q2 2021	35,422	$7,142	$209.17	$185.33 - $222.78
Q1 2021	12,608	$2,709	$219.65	$204.62 - $242.99
Q4 2020	32,087	$7,583	$229.44	$202.57 - $280.99
Q3 2019	158	$27	$176.91	$165.27 - $188.44
Q2 2019	5,382	$987	$174.82	$163.68 - $191.71
Q1 2019	5,947	$1,094	$184.70	$160.95 - $195.81
Q4 2018	158	$26	$173.27	$151.80 - $194.92
Q3 2018	1,902	$367	$178.07	$164.70 - $193.78
Q3 2017	2,600	$395	$150.51	$125.50 - $167.86
Q3 2016	28,284	$2,466	$94.50	$83.50 - $103.73
Q1 2016	4,600	$365	$90.45	$75.90 - $124.96