VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

APG Asset Management N.V.'s Holding History (CIK: 0001434819)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 188,385 Value ($000) $72,720 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 200,588 Value ($000) $66,858 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 201,952 Value ($000) $76,593 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 326,728 Value ($000) $146,643 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 359,285 Value ($000) $139,724 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 124,020 Value ($000) $51,682 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 357,884 Value ($000) $156,517 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 307,694 Value ($000) $119,092 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 342,694 Value ($000) $126,229 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 300,296 Value ($000) $104,425 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 326,456 Value ($000) $105,301 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 352,608 Value ($000) $102,256 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 418,642 Value ($000) $121 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 521,289 Value ($000) $154,069 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 820,355 Value ($000) $221,118 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 1,156,889 Value ($000) $271,346 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 1,206,589 Value ($000) $232,999 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,228,689 Value ($000) $192,305 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 1,275,589 Value ($000) $216,879 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 1,247,339 Value ($000) $228,061 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 1,300,221 Value ($000) $251,150 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 644,292 Value ($000) $149,512 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 643,192 Value ($000) $166,251 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 185,321 Value ($000) $44,097 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 58,167 Value ($000) $11,346 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 77,446 Value ($000) $12,035 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 81,697 Value ($000) $13,156 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 60,197 Value ($000) $9,862 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 60,197 Value ($000) $8,726 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 64,797 Value ($000) $10,752 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 82,097 Value ($000) $11,951 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 94,697 Value ($000) $12,549 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 168,597 Value ($000) $21,041 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 78,068 Value ($000) $11,869 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 69,168 Value ($000) $8,914 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 176,464 Value ($000) $19,296 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 281,778 Value ($000) $19,681 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 314,578 Value ($000) $27,434 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 314,178 Value ($000) $27,026 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 276,578 Value ($000) $21,985 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 334,178 Value ($000) $42,049,618 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 377,968 Value ($000) $39,362 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 388,571 Value ($000) $47,981 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 283,664 Value ($000) $33,464 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 288,433 Value ($000) $34,266 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 261,899 Value ($000) $29,414 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 285,776 Value ($000) $27,057 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 241,463 Value ($000) $17,076 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 217,549 Value ($000) $16,164 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 229,086 Value ($000) $17,369 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 270,435 Value ($000) $21,600 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	188,385	$72,720	$431.03	$392.50 - $464.44
Q3 2025	200,588	$66,858	$417.92	$362.50 - $484.56
Q2 2025	201,952	$76,593	$460.83	$416.60 - $510.77
Q1 2025	326,728	$146,643	$466.00	$397.25 - $519.68
Q4 2024	359,285	$139,724	$463.53	$377.85 - $519.88
Q3 2024	124,020	$51,682	$480.37	$456.07 - $510.64
Q2 2024	357,884	$156,517	$434.05	$391.01 - $486.43
Q1 2024	307,694	$119,092	$422.74	$403.43 - $448.40
Q4 2023	342,694	$126,229	$369.42	$341.85 - $413.00
Q3 2023	300,296	$104,425	$349.73	$335.82 - $367.00
Q2 2023	326,456	$105,301	$336.94	$313.47 - $354.94
Q1 2023	352,608	$102,256	$299.93	$282.21 - $325.19
Q4 2022	418,642	$121	$304.77	$283.58 - $324.75
Q3 2022	521,289	$154,069	$287.72	$271.61 - $305.95
Q2 2022	820,355	$221,118	$267.66	$233.01 - $293.17
Q1 2022	1,156,889	$271,346	$237.33	$214.66 - $263.58
Q4 2021	1,206,589	$232,999	$194.45	$176.36 - $224.49
Q3 2021	1,228,689	$192,305	$195.24	$180.02 - $204.88
Q2 2021	1,275,589	$216,879	$209.17	$185.33 - $222.78
Q1 2021	1,247,339	$228,061	$219.65	$204.62 - $242.99
Q4 2020	1,300,221	$251,150	$229.44	$202.57 - $280.99
Q3 2020	644,292	$149,512	$275.88	$253.97 - $306.08
Q2 2020	643,192	$166,251	$271.12	$222.39 - $299.21
Q1 2020	185,321	$44,097	$229.39	$197.47 - $249.85
Q4 2019	58,167	$11,346	$202.38	$165.23 - $225.66
Q3 2019	77,446	$12,035	$176.91	$165.27 - $188.44
Q2 2019	81,697	$13,156	$174.82	$163.68 - $191.71
Q1 2019	60,197	$9,862	$184.70	$160.95 - $195.81
Q4 2018	60,197	$8,726	$173.27	$151.80 - $194.92
Q3 2018	64,797	$10,752	$178.07	$164.70 - $193.78
Q2 2018	82,097	$11,951	$155.01	$144.07 - $172.00
Q1 2018	94,697	$12,549	$163.34	$146.21 - $178.15
Q4 2017	168,597	$21,041	$148.07	$136.50 - $158.04
Q3 2017	78,068	$11,869	$150.51	$125.50 - $167.86
Q2 2017	69,168	$8,914	$120.38	$107.24 - $137.26
Q1 2017	176,464	$19,296	$88.04	$73.34 - $111.88
Q4 2016	281,778	$19,681	$81.37	$71.46 - $97.93
Q3 2016	314,578	$27,434	$94.50	$83.50 - $103.73
Q2 2016	314,178	$27,026	$86.41	$75.92 - $96.49
Q1 2016	276,578	$21,985	$90.45	$75.90 - $124.96
Q4 2015	334,178	$42,049,618	$120.72	$101.49 - $134.71
Q3 2015	377,968	$39,362	$128.47	$97.45 - $143.45
Q2 2015	388,571	$47,981	$125.98	$113.68 - $137.50
Q1 2015	283,664	$33,464	$119.81	$103.75 - $136.33
Q4 2014	288,433	$34,266	$112.63	$96.43 - $124.35
Q3 2014	261,899	$29,414	$95.21	$84.41 - $116.88
Q2 2014	285,776	$27,057	$70.12	$59.79 - $98.80
Q1 2014	241,463	$17,076	$79.20	$67.49 - $87.77
Q4 2013	217,549	$16,164	$69.64	$58.06 - $78.38
Q3 2013	229,086	$17,369	$79.58	$73.43 - $89.96
Q2 2013	270,435	$21,600	$73.64	$51.28 - $87.47