VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Quantitative Investment Management, LLC's Holding History (CIK: 0001445911)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 3,657 Value ($000) $2 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 1,672 Value ($000) $1 Avg Close $417.92 Range $362.50 - $484.56

Q1 2025

Shares 14,997 Value ($000) $7 Avg Close $466.00 Range $397.25 - $519.68

Q2 2024

Shares 14,306 Value ($000) $7 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 20,794 Value ($000) $9 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 53,694 Value ($000) $22 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 3,179 Value ($000) $1 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 9,153 Value ($000) $3 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 11,053 Value ($000) $3 Avg Close $299.93 Range $282.21 - $325.19

Q4 2021

Shares 21,622 Value ($000) $4,748 Avg Close $194.45 Range $176.36 - $224.49

Q2 2020

Shares 18,876 Value ($000) $5,479 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 5,415 Value ($000) $1,288 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 182,475 Value ($000) $39,952 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 25,861 Value ($000) $4,381 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 28,779 Value ($000) $5,277 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 22,900 Value ($000) $4,212 Avg Close $184.70 Range $160.95 - $195.81

Q3 2018

Shares 25,900 Value ($000) $4,991 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 12,300 Value ($000) $2,090 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 10,800 Value ($000) $1,760 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 122,300 Value ($000) $18,327 Avg Close $148.07 Range $136.50 - $158.04

Q1 2017

Shares 102,100 Value ($000) $11,164 Avg Close $88.04 Range $73.34 - $111.88

Q3 2016

Shares 22,100 Value ($000) $1,927 Avg Close $94.50 Range $83.50 - $103.73

Q1 2016

Shares 3,600 Value ($000) $286 Avg Close $90.45 Range $75.90 - $124.96

Q4 2014

Shares 19,900 Value ($000) $2,364 Avg Close $112.63 Range $96.43 - $124.35

Q2 2014

Shares 13,500 Value ($000) $1,278 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 20,900 Value ($000) $1,478 Avg Close $79.20 Range $67.49 - $87.77

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	3,657	$2	$431.03	$392.50 - $464.44
Q3 2025	1,672	$1	$417.92	$362.50 - $484.56
Q1 2025	14,997	$7	$466.00	$397.25 - $519.68
Q2 2024	14,306	$7	$434.05	$391.01 - $486.43
Q1 2024	20,794	$9	$422.74	$403.43 - $448.40
Q4 2023	53,694	$22	$369.42	$341.85 - $413.00
Q3 2023	3,179	$1	$349.73	$335.82 - $367.00
Q2 2023	9,153	$3	$336.94	$313.47 - $354.94
Q1 2023	11,053	$3	$299.93	$282.21 - $325.19
Q4 2021	21,622	$4,748	$194.45	$176.36 - $224.49
Q2 2020	18,876	$5,479	$271.12	$222.39 - $299.21
Q1 2020	5,415	$1,288	$229.39	$197.47 - $249.85
Q4 2019	182,475	$39,952	$202.38	$165.23 - $225.66
Q3 2019	25,861	$4,381	$176.91	$165.27 - $188.44
Q2 2019	28,779	$5,277	$174.82	$163.68 - $191.71
Q1 2019	22,900	$4,212	$184.70	$160.95 - $195.81
Q3 2018	25,900	$4,991	$178.07	$164.70 - $193.78
Q2 2018	12,300	$2,090	$155.01	$144.07 - $172.00
Q1 2018	10,800	$1,760	$163.34	$146.21 - $178.15
Q4 2017	122,300	$18,327	$148.07	$136.50 - $158.04
Q1 2017	102,100	$11,164	$88.04	$73.34 - $111.88
Q3 2016	22,100	$1,927	$94.50	$83.50 - $103.73
Q1 2016	3,600	$286	$90.45	$75.90 - $124.96
Q4 2014	19,900	$2,364	$112.63	$96.43 - $124.35
Q2 2014	13,500	$1,278	$70.12	$59.79 - $98.80
Q1 2014	20,900	$1,478	$79.20	$67.49 - $87.77