VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

SUSQUEHANNA INTERNATIONAL GROUP, LLP's Holding History (CIK: 0001446194)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 84,096 Value ($000) $38,126 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 67,683 Value ($000) $26,507 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 62,209 Value ($000) $27,695 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 41,121 Value ($000) $19,936 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 130,405 Value ($000) $52,514 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 46,048 Value ($000) $21,416 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 79,578 Value ($000) $37,300 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 94,980 Value ($000) $39,703 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 125,884 Value ($000) $51,221 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 199,244 Value ($000) $69,285 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 174,286 Value ($000) $61,333 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 245,353 Value ($000) $77,303 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 279,001 Value ($000) $80,570 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 46,343 Value ($000) $13,418 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 108,121 Value ($000) $30,467 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 102,853 Value ($000) $26,842 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 336,325 Value ($000) $73,857 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 550,229 Value ($000) $99,806 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 503,547 Value ($000) $101,530 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 498,866 Value ($000) $107,201 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 251,720 Value ($000) $59,492 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 19,573 Value ($000) $5,326 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 148,312 Value ($000) $43,057 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 70,341 Value ($000) $16,738 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 117,705 Value ($000) $25,772 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 2,087 Value ($000) $354 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 14,470 Value ($000) $2,654 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 2,607 Value ($000) $480 Avg Close $184.70 Range $160.95 - $195.81

Q2 2018

Shares 23,588 Value ($000) $4,009 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 4,248 Value ($000) $692 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 4,369 Value ($000) $655 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 9,604 Value ($000) $1,460 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 6,092 Value ($000) $785 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 19,469 Value ($000) $2,129 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 33,089 Value ($000) $2,437 Avg Close $81.37 Range $71.46 - $97.93

Q2 2016

Shares 2,460 Value ($000) $212 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 56,659 Value ($000) $4,503 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 61,530 Value ($000) $7,743 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 161,482 Value ($000) $16,817 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 156,886 Value ($000) $19,372 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 110,460 Value ($000) $13,031 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 118,669 Value ($000) $14,098 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 145,457 Value ($000) $16,336 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 300,642 Value ($000) $28,465 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 170,510 Value ($000) $12,059 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 505,450 Value ($000) $37,555 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 236,693 Value ($000) $17,946 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 190,158 Value ($000) $15,188 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	84,096	$38,126	$431.03	$392.50 - $464.44
Q3 2025	67,683	$26,507	$417.92	$362.50 - $484.56
Q2 2025	62,209	$27,695	$460.83	$416.60 - $510.77
Q1 2025	41,121	$19,936	$466.00	$397.25 - $519.68
Q4 2024	130,405	$52,514	$463.53	$377.85 - $519.88
Q3 2024	46,048	$21,416	$480.37	$456.07 - $510.64
Q2 2024	79,578	$37,300	$434.05	$391.01 - $486.43
Q1 2024	94,980	$39,703	$422.74	$403.43 - $448.40
Q4 2023	125,884	$51,221	$369.42	$341.85 - $413.00
Q3 2023	199,244	$69,285	$349.73	$335.82 - $367.00
Q2 2023	174,286	$61,333	$336.94	$313.47 - $354.94
Q1 2023	245,353	$77,303	$299.93	$282.21 - $325.19
Q4 2022	279,001	$80,570	$304.77	$283.58 - $324.75
Q3 2022	46,343	$13,418	$287.72	$271.61 - $305.95
Q2 2022	108,121	$30,467	$267.66	$233.01 - $293.17
Q1 2022	102,853	$26,842	$237.33	$214.66 - $263.58
Q4 2021	336,325	$73,857	$194.45	$176.36 - $224.49
Q3 2021	550,229	$99,806	$195.24	$180.02 - $204.88
Q2 2021	503,547	$101,530	$209.17	$185.33 - $222.78
Q1 2021	498,866	$107,201	$219.65	$204.62 - $242.99
Q4 2020	251,720	$59,492	$229.44	$202.57 - $280.99
Q3 2020	19,573	$5,326	$275.88	$253.97 - $306.08
Q2 2020	148,312	$43,057	$271.12	$222.39 - $299.21
Q1 2020	70,341	$16,738	$229.39	$197.47 - $249.85
Q4 2019	117,705	$25,772	$202.38	$165.23 - $225.66
Q3 2019	2,087	$354	$176.91	$165.27 - $188.44
Q2 2019	14,470	$2,654	$174.82	$163.68 - $191.71
Q1 2019	2,607	$480	$184.70	$160.95 - $195.81
Q2 2018	23,588	$4,009	$155.01	$144.07 - $172.00
Q1 2018	4,248	$692	$163.34	$146.21 - $178.15
Q4 2017	4,369	$655	$148.07	$136.50 - $158.04
Q3 2017	9,604	$1,460	$150.51	$125.50 - $167.86
Q2 2017	6,092	$785	$120.38	$107.24 - $137.26
Q1 2017	19,469	$2,129	$88.04	$73.34 - $111.88
Q4 2016	33,089	$2,437	$81.37	$71.46 - $97.93
Q2 2016	2,460	$212	$86.41	$75.92 - $96.49
Q1 2016	56,659	$4,503	$90.45	$75.90 - $124.96
Q4 2015	61,530	$7,743	$120.72	$101.49 - $134.71
Q3 2015	161,482	$16,817	$128.47	$97.45 - $143.45
Q2 2015	156,886	$19,372	$125.98	$113.68 - $137.50
Q1 2015	110,460	$13,031	$119.81	$103.75 - $136.33
Q4 2014	118,669	$14,098	$112.63	$96.43 - $124.35
Q3 2014	145,457	$16,336	$95.21	$84.41 - $116.88
Q2 2014	300,642	$28,465	$70.12	$59.79 - $98.80
Q1 2014	170,510	$12,059	$79.20	$67.49 - $87.77
Q4 2013	505,450	$37,555	$69.64	$58.06 - $78.38
Q3 2013	236,693	$17,946	$79.58	$73.43 - $89.96
Q2 2013	190,158	$15,188	$73.64	$51.28 - $87.47