VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 5,141 Value ($000) $2,289 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 1,293 Value ($000) $627 Avg Close $466.00 Range $397.25 - $519.68

Q3 2024

Shares 4,205 Value ($000) $1,956 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 5,221 Value ($000) $2,447 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 3,952 Value ($000) $1,652 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 35,908 Value ($000) $14,611 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 5,935 Value ($000) $2,064 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 1,288 Value ($000) $453 Avg Close $336.94 Range $313.47 - $354.94

Q4 2022

Shares 903 Value ($000) $261 Avg Close $304.77 Range $283.58 - $324.75

Q2 2022

Shares 1,309 Value ($000) $369 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 24,303 Value ($000) $6,342 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 5,746 Value ($000) $1,262 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 1,291 Value ($000) $234 Avg Close $195.24 Range $180.02 - $204.88

Q1 2021

Shares 1,529 Value ($000) $329 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 2,828 Value ($000) $668 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 963 Value ($000) $262 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 1,601 Value ($000) $465 Avg Close $271.12 Range $222.39 - $299.21

Q4 2019

Shares 1,093 Value ($000) $239 Avg Close $202.38 Range $165.23 - $225.66

Q2 2019

Shares 2,864 Value ($000) $525 Avg Close $174.82 Range $163.68 - $191.71

Q4 2018

Shares 1,590 Value ($000) $263 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 10,359 Value ($000) $1,997 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 15,656 Value ($000) $2,661 Avg Close $155.01 Range $144.07 - $172.00

Q2 2017

Shares 2,431 Value ($000) $313 Avg Close $120.38 Range $107.24 - $137.26

Q4 2016

Shares 6,600 Value ($000) $486 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 9,180 Value ($000) $801 Avg Close $94.50 Range $83.50 - $103.73

Q1 2016

Shares 6,999 Value ($000) $556 Avg Close $90.45 Range $75.90 - $124.96

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	5,141	$2,289	$460.83	$416.60 - $510.77
Q1 2025	1,293	$627	$466.00	$397.25 - $519.68
Q3 2024	4,205	$1,956	$480.37	$456.07 - $510.64
Q2 2024	5,221	$2,447	$434.05	$391.01 - $486.43
Q1 2024	3,952	$1,652	$422.74	$403.43 - $448.40
Q4 2023	35,908	$14,611	$369.42	$341.85 - $413.00
Q3 2023	5,935	$2,064	$349.73	$335.82 - $367.00
Q2 2023	1,288	$453	$336.94	$313.47 - $354.94
Q4 2022	903	$261	$304.77	$283.58 - $324.75
Q2 2022	1,309	$369	$267.66	$233.01 - $293.17
Q1 2022	24,303	$6,342	$237.33	$214.66 - $263.58
Q4 2021	5,746	$1,262	$194.45	$176.36 - $224.49
Q3 2021	1,291	$234	$195.24	$180.02 - $204.88
Q1 2021	1,529	$329	$219.65	$204.62 - $242.99
Q4 2020	2,828	$668	$229.44	$202.57 - $280.99
Q3 2020	963	$262	$275.88	$253.97 - $306.08
Q2 2020	1,601	$465	$271.12	$222.39 - $299.21
Q4 2019	1,093	$239	$202.38	$165.23 - $225.66
Q2 2019	2,864	$525	$174.82	$163.68 - $191.71
Q4 2018	1,590	$263	$173.27	$151.80 - $194.92
Q3 2018	10,359	$1,997	$178.07	$164.70 - $193.78
Q2 2018	15,656	$2,661	$155.01	$144.07 - $172.00
Q2 2017	2,431	$313	$120.38	$107.24 - $137.26
Q4 2016	6,600	$486	$81.37	$71.46 - $97.93
Q3 2016	9,180	$801	$94.50	$83.50 - $103.73
Q1 2016	6,999	$556	$90.45	$75.90 - $124.96