VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

Alyeska Investment Group, L.P.'s Holding History (CIK: 0001453072)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 354,334 Value ($000) $160,641 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 267,169 Value ($000) $104,634 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 65,000 Value ($000) $28,938 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 431,804 Value ($000) $209,347 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 77,535 Value ($000) $31,223 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 3,353 Value ($000) $1,559 Avg Close $480.37 Range $456.07 - $510.64

Q2 2023

Shares 162,049 Value ($000) $57,027 Avg Close $336.94 Range $313.47 - $354.94

Q1 2021

Shares 95,881 Value ($000) $20,604 Avg Close $219.65 Range $204.62 - $242.99

Q2 2019

Shares 3,811 Value ($000) $699 Avg Close $174.82 Range $163.68 - $191.71

Q2 2017

Shares 7,503 Value ($000) $967 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 120,189 Value ($000) $13,143 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 222,034 Value ($000) $16,357 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 125,000 Value ($000) $10,901 Avg Close $94.50 Range $83.50 - $103.73

Q4 2015

Shares 269,490 Value ($000) $33,910 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 403,355 Value ($000) $42,005 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 150,780 Value ($000) $18,618 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 159,488 Value ($000) $18,815 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 151,468 Value ($000) $17,994 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 43,750 Value ($000) $4,914 Avg Close $95.21 Range $84.41 - $116.88

Q2 2013

Shares 85,000 Value ($000) $6,805 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	354,334	$160,641	$431.03	$392.50 - $464.44
Q3 2025	267,169	$104,634	$417.92	$362.50 - $484.56
Q2 2025	65,000	$28,938	$460.83	$416.60 - $510.77
Q1 2025	431,804	$209,347	$466.00	$397.25 - $519.68
Q4 2024	77,535	$31,223	$463.53	$377.85 - $519.88
Q3 2024	3,353	$1,559	$480.37	$456.07 - $510.64
Q2 2023	162,049	$57,027	$336.94	$313.47 - $354.94
Q1 2021	95,881	$20,604	$219.65	$204.62 - $242.99
Q2 2019	3,811	$699	$174.82	$163.68 - $191.71
Q2 2017	7,503	$967	$120.38	$107.24 - $137.26
Q1 2017	120,189	$13,143	$88.04	$73.34 - $111.88
Q4 2016	222,034	$16,357	$81.37	$71.46 - $97.93
Q3 2016	125,000	$10,901	$94.50	$83.50 - $103.73
Q4 2015	269,490	$33,910	$120.72	$101.49 - $134.71
Q3 2015	403,355	$42,005	$128.47	$97.45 - $143.45
Q2 2015	150,780	$18,618	$125.98	$113.68 - $137.50
Q1 2015	159,488	$18,815	$119.81	$103.75 - $136.33
Q4 2014	151,468	$17,994	$112.63	$96.43 - $124.35
Q3 2014	43,750	$4,914	$95.21	$84.41 - $116.88
Q2 2013	85,000	$6,805	$73.64	$51.28 - $87.47