VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

DekaBank Deutsche Girozentrale's Holding History (CIK: 0001456228)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 506,457 Value ($000) $220 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 506,457 Value ($000) $200 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 506,457 Value ($000) $223 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 491,129 Value ($000) $239 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 506,457 Value ($000) $205 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 506,457 Value ($000) $233 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 501,509 Value ($000) $237 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 491,129 Value ($000) $204 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 503,978 Value ($000) $206 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 470,058 Value ($000) $166 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 466,038 Value ($000) $163 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 452,403 Value ($000) $141 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 433,645 Value ($000) $125 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 422,718 Value ($000) $123,007 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 472,504 Value ($000) $131,466 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 480,140 Value ($000) $124,145 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 338,255 Value ($000) $75,984 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 344,709 Value ($000) $62,991 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 335,925 Value ($000) $66,135 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 297,676 Value ($000) $63,598 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 234,495 Value ($000) $54,692 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 255,408 Value ($000) $68,266 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 62,182 Value ($000) $17,678 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 58,449 Value ($000) $13,665 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 61,344 Value ($000) $13,515 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 233,034 Value ($000) $39,025 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 374,164 Value ($000) $67,002 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 106,657 Value ($000) $20,008 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 103,183 Value ($000) $16,880 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 106,657 Value ($000) $20,008 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 137,434 Value ($000) $20,742 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 177,399 Value ($000) $28,537 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 153,362 Value ($000) $23,343 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 153,362 Value ($000) $23,343 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 176,434 Value ($000) $22,587 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 171,181 Value ($000) $18,454 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 170,175 Value ($000) $12,695 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 183,571 Value ($000) $15,633 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 251,401 Value ($000) $21,389 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 235,709 Value ($000) $18,490 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 192,417 Value ($000) $24,568 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 232,377 Value ($000) $23,721 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 181,231 Value ($000) $22,532 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 173,689 Value ($000) $20,839 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 166,689 Value ($000) $19,896 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 173,735 Value ($000) $19,696 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 219,090 Value ($000) $20,544 Avg Close $70.12 Range $59.79 - $98.80

Q1 2014

Shares 214,440 Value ($000) $14,618 Avg Close $79.20 Range $67.49 - $87.77

Q4 2013

Shares 180,210 Value ($000) $13,263 Avg Close $69.64 Range $58.06 - $78.38

Q3 2013

Shares 155,944 Value ($000) $11,746 Avg Close $79.58 Range $73.43 - $89.96

Q2 2013

Shares 151,647 Value ($000) $12,162 Avg Close $73.64 Range $51.28 - $87.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	506,457	$220	$431.03	$392.50 - $464.44
Q3 2025	506,457	$200	$417.92	$362.50 - $484.56
Q2 2025	506,457	$223	$460.83	$416.60 - $510.77
Q1 2025	491,129	$239	$466.00	$397.25 - $519.68
Q4 2024	506,457	$205	$463.53	$377.85 - $519.88
Q3 2024	506,457	$233	$480.37	$456.07 - $510.64
Q2 2024	501,509	$237	$434.05	$391.01 - $486.43
Q1 2024	491,129	$204	$422.74	$403.43 - $448.40
Q4 2023	503,978	$206	$369.42	$341.85 - $413.00
Q3 2023	470,058	$166	$349.73	$335.82 - $367.00
Q2 2023	466,038	$163	$336.94	$313.47 - $354.94
Q1 2023	452,403	$141	$299.93	$282.21 - $325.19
Q4 2022	433,645	$125	$304.77	$283.58 - $324.75
Q3 2022	422,718	$123,007	$287.72	$271.61 - $305.95
Q2 2022	472,504	$131,466	$267.66	$233.01 - $293.17
Q1 2022	480,140	$124,145	$237.33	$214.66 - $263.58
Q4 2021	338,255	$75,984	$194.45	$176.36 - $224.49
Q3 2021	344,709	$62,991	$195.24	$180.02 - $204.88
Q2 2021	335,925	$66,135	$209.17	$185.33 - $222.78
Q1 2021	297,676	$63,598	$219.65	$204.62 - $242.99
Q4 2020	234,495	$54,692	$229.44	$202.57 - $280.99
Q3 2020	255,408	$68,266	$275.88	$253.97 - $306.08
Q2 2020	62,182	$17,678	$271.12	$222.39 - $299.21
Q1 2020	58,449	$13,665	$229.39	$197.47 - $249.85
Q4 2019	61,344	$13,515	$202.38	$165.23 - $225.66
Q3 2019	233,034	$39,025	$176.91	$165.27 - $188.44
Q2 2019	374,164	$67,002	$174.82	$163.68 - $191.71
Q1 2019	106,657	$20,008	$184.70	$160.95 - $195.81
Q4 2018	103,183	$16,880	$173.27	$151.80 - $194.92
Q3 2018	106,657	$20,008	$178.07	$164.70 - $193.78
Q2 2018	137,434	$20,742	$155.01	$144.07 - $172.00
Q1 2018	177,399	$28,537	$163.34	$146.21 - $178.15
Q4 2017	153,362	$23,343	$148.07	$136.50 - $158.04
Q3 2017	153,362	$23,343	$150.51	$125.50 - $167.86
Q2 2017	176,434	$22,587	$120.38	$107.24 - $137.26
Q1 2017	171,181	$18,454	$88.04	$73.34 - $111.88
Q4 2016	170,175	$12,695	$81.37	$71.46 - $97.93
Q3 2016	183,571	$15,633	$94.50	$83.50 - $103.73
Q2 2016	251,401	$21,389	$86.41	$75.92 - $96.49
Q1 2016	235,709	$18,490	$90.45	$75.90 - $124.96
Q4 2015	192,417	$24,568	$120.72	$101.49 - $134.71
Q3 2015	232,377	$23,721	$128.47	$97.45 - $143.45
Q2 2015	181,231	$22,532	$125.98	$113.68 - $137.50
Q1 2015	173,689	$20,839	$119.81	$103.75 - $136.33
Q4 2014	166,689	$19,896	$112.63	$96.43 - $124.35
Q3 2014	173,735	$19,696	$95.21	$84.41 - $116.88
Q2 2014	219,090	$20,544	$70.12	$59.79 - $98.80
Q1 2014	214,440	$14,618	$79.20	$67.49 - $87.77
Q4 2013	180,210	$13,263	$69.64	$58.06 - $78.38
Q3 2013	155,944	$11,746	$79.58	$73.43 - $89.96
Q2 2013	151,647	$12,162	$73.64	$51.28 - $87.47