VERTEX PHARMACEUTICALS INC

Ticker: VRTX CUSIP: 92532F100 Class: EQTY

DnB Asset Management AS's Holding History (CIK: 0001456670)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 119,685 Value ($000) $54,260 Avg Close $431.03 Range $392.50 - $464.44

Q3 2025

Shares 95,414 Value ($000) $37,368 Avg Close $417.92 Range $362.50 - $484.56

Q2 2025

Shares 86,931 Value ($000) $38,702 Avg Close $460.83 Range $416.60 - $510.77

Q1 2025

Shares 176,531 Value ($000) $85,586 Avg Close $466.00 Range $397.25 - $519.68

Q4 2024

Shares 200,942 Value ($000) $80,919 Avg Close $463.53 Range $377.85 - $519.88

Q3 2024

Shares 181,653 Value ($000) $84,483 Avg Close $480.37 Range $456.07 - $510.64

Q2 2024

Shares 166,722 Value ($000) $78,146 Avg Close $434.05 Range $391.01 - $486.43

Q1 2024

Shares 191,250 Value ($000) $79,944 Avg Close $422.74 Range $403.43 - $448.40

Q4 2023

Shares 198,418 Value ($000) $80,734 Avg Close $369.42 Range $341.85 - $413.00

Q3 2023

Shares 192,207 Value ($000) $66,838 Avg Close $349.73 Range $335.82 - $367.00

Q2 2023

Shares 208,605 Value ($000) $73,410 Avg Close $336.94 Range $313.47 - $354.94

Q1 2023

Shares 283,647 Value ($000) $89,369 Avg Close $299.93 Range $282.21 - $325.19

Q4 2022

Shares 299,763 Value ($000) $86,566 Avg Close $304.77 Range $283.58 - $324.75

Q3 2022

Shares 315,982 Value ($000) $91,489,428 Avg Close $287.72 Range $271.61 - $305.95

Q2 2022

Shares 345,203 Value ($000) $97,274,753 Avg Close $267.66 Range $233.01 - $293.17

Q1 2022

Shares 351,478 Value ($000) $91,725,214 Avg Close $237.33 Range $214.66 - $263.58

Q4 2021

Shares 487,895 Value ($000) $107,141,742 Avg Close $194.45 Range $176.36 - $224.49

Q3 2021

Shares 509,902 Value ($000) $92,491,124 Avg Close $195.24 Range $180.02 - $204.88

Q2 2021

Shares 423,309 Value ($000) $85,351,794 Avg Close $209.17 Range $185.33 - $222.78

Q1 2021

Shares 73,779 Value ($000) $15,854,369 Avg Close $219.65 Range $204.62 - $242.99

Q4 2020

Shares 38,453 Value ($000) $9,087,982 Avg Close $229.44 Range $202.57 - $280.99

Q3 2020

Shares 34,735 Value ($000) $9,452,088 Avg Close $275.88 Range $253.97 - $306.08

Q2 2020

Shares 32,160 Value ($000) $9,336,370 Avg Close $271.12 Range $222.39 - $299.21

Q1 2020

Shares 26,904 Value ($000) $6,401,807 Avg Close $229.39 Range $197.47 - $249.85

Q4 2019

Shares 32,142 Value ($000) $7,037,491 Avg Close $202.38 Range $165.23 - $225.66

Q3 2019

Shares 27,745 Value ($000) $4,700,558 Avg Close $176.91 Range $165.27 - $188.44

Q2 2019

Shares 25,801 Value ($000) $4,731,387 Avg Close $174.82 Range $163.68 - $191.71

Q1 2019

Shares 27,436 Value ($000) $5,046,852 Avg Close $184.70 Range $160.95 - $195.81

Q4 2018

Shares 30,520 Value ($000) $5,057,469 Avg Close $173.27 Range $151.80 - $194.92

Q3 2018

Shares 32,624 Value ($000) $6,287,950 Avg Close $178.07 Range $164.70 - $193.78

Q2 2018

Shares 31,580 Value ($000) $5,367,337 Avg Close $155.01 Range $144.07 - $172.00

Q1 2018

Shares 29,180 Value ($000) $4,755,756 Avg Close $163.34 Range $146.21 - $178.15

Q4 2017

Shares 26,280 Value ($000) $3,938,321 Avg Close $148.07 Range $136.50 - $158.04

Q3 2017

Shares 25,680 Value ($000) $3,904,387 Avg Close $150.51 Range $125.50 - $167.86

Q2 2017

Shares 25,780 Value ($000) $3,322,269 Avg Close $120.38 Range $107.24 - $137.26

Q1 2017

Shares 26,480 Value ($000) $2,895,588 Avg Close $88.04 Range $73.34 - $111.88

Q4 2016

Shares 22,380 Value ($000) $1,648,735 Avg Close $81.37 Range $71.46 - $97.93

Q3 2016

Shares 21,180 Value ($000) $1,847,108 Avg Close $94.50 Range $83.50 - $103.73

Q2 2016

Shares 19,780 Value ($000) $1,701,476 Avg Close $86.41 Range $75.92 - $96.49

Q1 2016

Shares 18,280 Value ($000) $1,453,077 Avg Close $90.45 Range $75.90 - $124.96

Q4 2015

Shares 13,580 Value ($000) $1,708,771 Avg Close $120.72 Range $101.49 - $134.71

Q3 2015

Shares 31,965 Value ($000) $3,328,835 Avg Close $128.47 Range $97.45 - $143.45

Q2 2015

Shares 52,090 Value ($000) $6,432,073 Avg Close $125.98 Range $113.68 - $137.50

Q1 2015

Shares 42,590 Value ($000) $5,024,342 Avg Close $119.81 Range $103.75 - $136.33

Q4 2014

Shares 56,290 Value ($000) $6,687,252 Avg Close $112.63 Range $96.43 - $124.35

Q3 2014

Shares 55,190 Value ($000) $6,198,389 Avg Close $95.21 Range $84.41 - $116.88

Q2 2014

Shares 35,080 Value ($000) $3,321,374 Avg Close $70.12 Range $59.79 - $98.80

Q4 2013

Shares 63,080 Value ($000) $4,686,844 Avg Close $69.64 Range $58.06 - $78.38

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	119,685	$54,260	$431.03	$392.50 - $464.44
Q3 2025	95,414	$37,368	$417.92	$362.50 - $484.56
Q2 2025	86,931	$38,702	$460.83	$416.60 - $510.77
Q1 2025	176,531	$85,586	$466.00	$397.25 - $519.68
Q4 2024	200,942	$80,919	$463.53	$377.85 - $519.88
Q3 2024	181,653	$84,483	$480.37	$456.07 - $510.64
Q2 2024	166,722	$78,146	$434.05	$391.01 - $486.43
Q1 2024	191,250	$79,944	$422.74	$403.43 - $448.40
Q4 2023	198,418	$80,734	$369.42	$341.85 - $413.00
Q3 2023	192,207	$66,838	$349.73	$335.82 - $367.00
Q2 2023	208,605	$73,410	$336.94	$313.47 - $354.94
Q1 2023	283,647	$89,369	$299.93	$282.21 - $325.19
Q4 2022	299,763	$86,566	$304.77	$283.58 - $324.75
Q3 2022	315,982	$91,489,428	$287.72	$271.61 - $305.95
Q2 2022	345,203	$97,274,753	$267.66	$233.01 - $293.17
Q1 2022	351,478	$91,725,214	$237.33	$214.66 - $263.58
Q4 2021	487,895	$107,141,742	$194.45	$176.36 - $224.49
Q3 2021	509,902	$92,491,124	$195.24	$180.02 - $204.88
Q2 2021	423,309	$85,351,794	$209.17	$185.33 - $222.78
Q1 2021	73,779	$15,854,369	$219.65	$204.62 - $242.99
Q4 2020	38,453	$9,087,982	$229.44	$202.57 - $280.99
Q3 2020	34,735	$9,452,088	$275.88	$253.97 - $306.08
Q2 2020	32,160	$9,336,370	$271.12	$222.39 - $299.21
Q1 2020	26,904	$6,401,807	$229.39	$197.47 - $249.85
Q4 2019	32,142	$7,037,491	$202.38	$165.23 - $225.66
Q3 2019	27,745	$4,700,558	$176.91	$165.27 - $188.44
Q2 2019	25,801	$4,731,387	$174.82	$163.68 - $191.71
Q1 2019	27,436	$5,046,852	$184.70	$160.95 - $195.81
Q4 2018	30,520	$5,057,469	$173.27	$151.80 - $194.92
Q3 2018	32,624	$6,287,950	$178.07	$164.70 - $193.78
Q2 2018	31,580	$5,367,337	$155.01	$144.07 - $172.00
Q1 2018	29,180	$4,755,756	$163.34	$146.21 - $178.15
Q4 2017	26,280	$3,938,321	$148.07	$136.50 - $158.04
Q3 2017	25,680	$3,904,387	$150.51	$125.50 - $167.86
Q2 2017	25,780	$3,322,269	$120.38	$107.24 - $137.26
Q1 2017	26,480	$2,895,588	$88.04	$73.34 - $111.88
Q4 2016	22,380	$1,648,735	$81.37	$71.46 - $97.93
Q3 2016	21,180	$1,847,108	$94.50	$83.50 - $103.73
Q2 2016	19,780	$1,701,476	$86.41	$75.92 - $96.49
Q1 2016	18,280	$1,453,077	$90.45	$75.90 - $124.96
Q4 2015	13,580	$1,708,771	$120.72	$101.49 - $134.71
Q3 2015	31,965	$3,328,835	$128.47	$97.45 - $143.45
Q2 2015	52,090	$6,432,073	$125.98	$113.68 - $137.50
Q1 2015	42,590	$5,024,342	$119.81	$103.75 - $136.33
Q4 2014	56,290	$6,687,252	$112.63	$96.43 - $124.35
Q3 2014	55,190	$6,198,389	$95.21	$84.41 - $116.88
Q2 2014	35,080	$3,321,374	$70.12	$59.79 - $98.80
Q4 2013	63,080	$4,686,844	$69.64	$58.06 - $78.38